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Protein
Submitted name:

Transcriptional regulator (NtrC family)

Gene

ntrC1

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140ATP; via amide nitrogen and carbonyl oxygenCombined sources1
Metal bindingi238MagnesiumCombined sources1
Metal bindingi239MagnesiumCombined sources1
Binding sitei280ADPCombined sources1
Binding sitei280ATPCombined sources1
Binding sitei299ATPCombined sources1
Binding sitei357ATPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 141ADPCombined sources5
Nucleotide bindingi167 – 174ATPPROSITE-ProRule annotation8
Nucleotide bindingi169 – 175ADPCombined sources7
Nucleotide bindingi169 – 175ATPCombined sources7
Nucleotide bindingi230 – 239ATPPROSITE-ProRule annotation10
Nucleotide bindingi238 – 239ADPCombined sources2
Nucleotide bindingi357 – 360ADPCombined sources4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationCombined sourcesSAAS annotation, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator (NtrC family)Imported
Gene namesi
Name:ntrC1Imported
Ordered Locus Names:aq_1117Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1
Disulfide bondi158 ↔ 161Combined sources

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription factor binding Source: InterPro

Protein-protein interaction databases

DIPiDIP-59014N.
IntActiO67198. 1 interactor.
STRINGi224324.aq_1117.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NY5X-ray2.40A/B1-387[»]
1NY6X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L/M/N121-387[»]
1ZY2X-ray3.03A/B1-136[»]
3M0EX-ray2.63A/B/C/D/E/F/G122-387[»]
4BS1electron microscopy18.00A312-384[»]
B137-309[»]
4BT0electron microscopy17.00A312-384[»]
B137-309[»]
4BT1electron microscopy16.00A312-384[»]
B137-309[»]
4L4UX-ray2.20A1-439[»]
4L5EX-ray1.34A393-438[»]
4LY6X-ray3.60A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X121-387[»]
4LZZX-ray3.21A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X121-387[»]
ProteinModelPortaliO67198.
SMRiO67198.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 116Response regulatoryInterPro annotationAdd BLAST115
Domaini139 – 368Sigma-54 factor interactionInterPro annotationAdd BLAST230

Phylogenomic databases

eggNOGiENOG4105C1W. Bacteria.
COG2204. LUCA.
HOGENOMiHOG000058489.
InParanoidiO67198.
KOiK02481.
OMAiMRQISEQ.
OrthoDBiPOG091H03UM.

Family and domain databases

CDDicd00156. REC. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011006. CheY-like_superfamily.
IPR009057. Homeobox-like_sf.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
PfamiView protein in Pfam
PF02954. HTH_8. 1 hit.
PF00072. Response_reg. 1 hit.
PF00158. Sigma54_activat. 1 hit.
PRINTSiPR01590. HTHFIS.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00448. REC. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50110. RESPONSE_REGULATORY. 1 hit.
PS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.

Sequencei

Sequence statusi: Complete.

O67198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLVIEDDK VFRGLLEEYL SMKGIKVESA ERGKEAYKLL SEKHFNVVLL
60 70 80 90 100
DLLLPDVNGL EILKWIKERS PETEVIVITG HGTIKTAVEA MKMGAYDFLT
110 120 130 140 150
KPCMLEEIEL TINKAIEHRK LRKENELLRR EKDLKEEEYV FESPKMKEIL
160 170 180 190 200
EKIKKISCAE CPVLITGESG VGKEVVARLI HKLSDRSKEP FVALNVASIP
210 220 230 240 250
RDIFEAELFG YEKGAFTGAV SSKEGFFELA DGGTLFLDEI GELSLEAQAK
260 270 280 290 300
LLRVIESGKF YRLGGRKEIE VNVRILAATN RNIKELVKEG KFREDLYYRL
310 320 330 340 350
GVIEIEIPPL RERKEDIIPL ANHFLKKFSR KYAKEVEGFT KSAQELLLSY
360 370 380 390 400
PWYGNVRELK NVIERAVLFS EGKFIDRGEL SCLVNSKGIK NKHKSIKEIE
410 420 430
KEEIIKVLKE VNFNKKLASE ILGIPLRTLY RRLKEYGIE
Length:439
Mass (Da):50,367
Last modified:August 1, 1998 - v1
Checksum:iAAE1E9780271DFC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07159.1.
PIRiC70396.
RefSeqiNP_213762.1. NC_000918.1.
WP_010880700.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07159; AAC07159; aq_1117.
GeneIDi1192544.
KEGGiaae:aq_1117.

Similar proteinsi

Entry informationi

Entry nameiO67198_AQUAE
AccessioniPrimary (citable) accession number: O67198
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported