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Protein
Submitted name:

Transcriptional regulator (NtrC family)

Gene

ntrC1

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140ATP; via amide nitrogen and carbonyl oxygenCombined sources1
Metal bindingi238MagnesiumCombined sources1
Metal bindingi239MagnesiumCombined sources1
Binding sitei280ADPCombined sources1
Binding sitei280ATPCombined sources1
Binding sitei299ATPCombined sources1
Binding sitei357ATPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 141ADPCombined sources5
Nucleotide bindingi167 – 174ATPPROSITE-ProRule annotation8
Nucleotide bindingi169 – 175ADPCombined sources7
Nucleotide bindingi169 – 175ATPCombined sources7
Nucleotide bindingi230 – 239ATPPROSITE-ProRule annotation10
Nucleotide bindingi238 – 239ADPCombined sources2
Nucleotide bindingi357 – 360ADPCombined sources4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationCombined sourcesSAAS annotation, MagnesiumCombined sources, Metal-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-791-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator (NtrC family)Imported
Gene namesi
Name:ntrC1Imported
Ordered Locus Names:aq_1117Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei514-aspartylphosphatePROSITE-ProRule annotation1
Disulfide bondi158 ↔ 161Combined sources

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription factor binding Source: InterPro

Protein-protein interaction databases

DIPiDIP-59014N
IntActiO67198, 1 interactor
STRINGi224324.aq_1117

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NY5X-ray2.40A/B1-387[»]
1NY6X-ray3.10A/B/C/D/E/F/G/H/I/J/K/L/M/N121-387[»]
1ZY2X-ray3.03A/B1-136[»]
3M0EX-ray2.63A/B/C/D/E/F/G122-387[»]
4BS1electron microscopy18.00A312-384[»]
B137-309[»]
4BT0electron microscopy17.00A312-384[»]
B137-309[»]
4BT1electron microscopy16.00A312-384[»]
B137-309[»]
4L4UX-ray2.20A1-439[»]
4L5EX-ray1.34A393-438[»]
4LY6X-ray3.60A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X121-387[»]
4LZZX-ray3.21A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X121-387[»]
ProteinModelPortaliO67198
SMRiO67198
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67198

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 116Response regulatoryInterPro annotationAdd BLAST115
Domaini139 – 368Sigma-54 factor interactionInterPro annotationAdd BLAST230

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 138Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105C1W Bacteria
COG2204 LUCA
HOGENOMiHOG000058489
InParanoidiO67198
KOiK02481
OMAiDRNRTEF
OrthoDBiPOG091H03UM

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011006 CheY-like_superfamily
IPR009057 Homeobox-like_sf
IPR002197 HTH_Fis
IPR027417 P-loop_NTPase
IPR001789 Sig_transdc_resp-reg_receiver
IPR002078 Sigma_54_int
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR025943 Sigma_54_int_dom_ATP-bd_2
PfamiView protein in Pfam
PF02954 HTH_8, 1 hit
PF00072 Response_reg, 1 hit
PF00158 Sigma54_activat, 1 hit
PRINTSiPR01590 HTHFIS
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00448 REC, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF52172 SSF52172, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50110 RESPONSE_REGULATORY, 1 hit
PS00675 SIGMA54_INTERACT_1, 1 hit
PS00676 SIGMA54_INTERACT_2, 1 hit
PS50045 SIGMA54_INTERACT_4, 1 hit

Sequencei

Sequence statusi: Complete.

O67198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLVIEDDK VFRGLLEEYL SMKGIKVESA ERGKEAYKLL SEKHFNVVLL
60 70 80 90 100
DLLLPDVNGL EILKWIKERS PETEVIVITG HGTIKTAVEA MKMGAYDFLT
110 120 130 140 150
KPCMLEEIEL TINKAIEHRK LRKENELLRR EKDLKEEEYV FESPKMKEIL
160 170 180 190 200
EKIKKISCAE CPVLITGESG VGKEVVARLI HKLSDRSKEP FVALNVASIP
210 220 230 240 250
RDIFEAELFG YEKGAFTGAV SSKEGFFELA DGGTLFLDEI GELSLEAQAK
260 270 280 290 300
LLRVIESGKF YRLGGRKEIE VNVRILAATN RNIKELVKEG KFREDLYYRL
310 320 330 340 350
GVIEIEIPPL RERKEDIIPL ANHFLKKFSR KYAKEVEGFT KSAQELLLSY
360 370 380 390 400
PWYGNVRELK NVIERAVLFS EGKFIDRGEL SCLVNSKGIK NKHKSIKEIE
410 420 430
KEEIIKVLKE VNFNKKLASE ILGIPLRTLY RRLKEYGIE
Length:439
Mass (Da):50,367
Last modified:August 1, 1998 - v1
Checksum:iAAE1E9780271DFC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07159.1
PIRiC70396
RefSeqiNP_213762.1, NC_000918.1
WP_010880700.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07159; AAC07159; aq_1117
GeneIDi1192544
KEGGiaae:aq_1117

Similar proteinsi

Entry informationi

Entry nameiO67198_AQUAE
AccessioniPrimary (citable) accession number: O67198
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health