Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O67193 (GCSPA_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Synonyms:gcsP2
Ordered Locus Names:aq_1109
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166953

Sequences

Sequence LengthMass (Da)Tools
O67193 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 88953271141E75EA

FASTA43949,722
        10         20         30         40         50         60 
MSYIPHSEEE TKEILSKLGL ESLEDLFSHI PKELFAKDFS FPEPKSEEEL RRIFERACED 

        70         80         90        100        110        120 
TELPLYFIGA GAYDRIIPSV IWQILSRGEF LTPYTPYQAE ASQGTLQAIF EYQSLICELT 

       130        140        150        160        170        180 
GMDVANASMY DGASALAEAV LMARAIKGKG DTVVLSKALN PLYRRTVKTY LRGYEDKIVE 

       190        200        210        220        230        240 
VPYTEEGTTD LNNLEEVLKE SEVHALAVQY PNFFGFVEPL KEIGELCKKY EVPFVVFVDP 

       250        260        270        280        290        300 
IALSILKPPA EFGADIVVGE GQQMGIPLSF GGPYVGFFAT KKEHVRKMPG RLVGMGEDIE 

       310        320        330        340        350        360 
GKRAFTLVLQ TREQHIRRER ATSNICTNQN LMALANLLYM VLLGKEGMKK VAVQSLSKAL 

       370        380        390        400        410        420 
YFKKELMKKG FEEVFTGKHL WEFPLRHESL KAIYRKLLKE KIVLGLPLDR FYEDLKNTTL 

       430 
IAVTEKRTKE EIDSVLALL 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC07143.1.
PIRF70395.
RefSeqNP_213757.1. NC_000918.1.

3D structure databases

ProteinModelPortalO67193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_1109.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC07143; AAC07143; aq_1109.
GeneID1193827.
KEGGaae:aq_1109.
PATRIC20959492. VBIAquAeo85532_0866.

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-792-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_AQUAE
AccessionPrimary (citable) accession number: O67193
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families