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Protein

GDP-mannose 4,6-dehydratase

Gene

rfbD

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.UniRule annotation

Catalytic activityi

GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O.UniRule annotation

Cofactori

NADP+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151NADPCombined sources1
Binding sitei155NADPCombined sources1
Binding sitei181NADPCombined sources1
Binding sitei186NADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 15NADPCombined sources2
Nucleotide bindingi34 – 36NADPCombined sources3
Nucleotide bindingi60 – 61NADPCombined sources2
Nucleotide bindingi82 – 86NADPCombined sources5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
LigandNADPUniRule annotationCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-mannose 4,6-dehydrataseUniRule annotation (EC:4.2.1.47UniRule annotation)
Alternative name(s):
GDP-D-mannose dehydrataseUniRule annotation
Gene namesi
Name:rfbDImported
Synonyms:gmdUniRule annotation
Ordered Locus Names:aq_1082Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1082.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z1MX-ray2.00A/B/C/D1-345[»]
2Z95X-ray2.60A/B/C/D1-345[»]
ProteinModelPortaliO67175.
SMRiO67175.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67175.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 330NAD(P)-bd_domInterPro annotationAdd BLAST324

Sequence similaritiesi

Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C0K. Bacteria.
COG1089. LUCA.
HOGENOMiHOG000168003.
InParanoidiO67175.
KOiK01711.
OMAiTDCLYLG.
OrthoDBiPOG091H0MRZ.

Family and domain databases

HAMAPiMF_00955. GDP_Man_dehydratase. 1 hit.
InterProiView protein in InterPro
IPR006368. GDP_Man_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF16363. GDP_Man_Dehyd. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR01472. gmd. 1 hit.

Sequencei

Sequence statusi: Complete.

O67175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKRALITG IRGQDGAYLA KLLLEKGYEV YGADRRSGEF ASWRLKELGI
60 70 80 90 100
ENDVKIIHMD LLEFSNIIRT IEKVQPDEVY NLAAQSFVGV SFEQPILTAE
110 120 130 140 150
VDAIGVLRIL EALRTVKPDT KFYQASTSEM FGKVQEIPQT EKTPFYPRSP
160 170 180 190 200
YAVAKLFGHW ITVNYREAYN MFACSGILFN HESPLRGIEF VTRKITYSLA
210 220 230 240 250
RIKYGLQDKL VLGNLNAKRD WGYAPEYVEA MWLMMQQPEP DDYVIATGET
260 270 280 290 300
HTVREFVEKA AKIAGFDIEW VGEGINEKGI DRNTGKVIVE VSEEFFRPAE
310 320 330 340
VDILVGNPEK AMKKLGWKPR TTFDELVEIM MEADLKRVRD REVSV
Length:345
Mass (Da):39,338
Last modified:August 1, 1998 - v1
Checksum:iCEEC5FFD4CA2710A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07133.1.
PIRiD70393.
RefSeqiNP_213738.1. NC_000918.1.
WP_010880676.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07133; AAC07133; aq_1082.
GeneIDi1193809.
KEGGiaae:aq_1082.
PATRICifig|224324.8.peg.842.

Similar proteinsi

Entry informationi

Entry nameiO67175_AQUAE
AccessioniPrimary (citable) accession number: O67175
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 25, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported