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Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29ZincBy similarity1
Metal bindingi209ZincBy similarity1
Metal bindingi234ZincBy similarity1
Metal bindingi238ZincBy similarity1
Binding sitei269ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-755-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligase (EC:6.1.1.16)
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name:
CysRS
Gene namesi
Name:cysS
Ordered Locus Names:aq_1068
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001593401 – 495Cysteine--tRNA ligaseAdd BLAST495

Proteomic databases

PRIDEiO67163

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_1068

Structurei

3D structure databases

ProteinModelPortaliO67163
SMRiO67163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 41"HIGH" regionAdd BLAST11
Motifi266 – 270"KMSKS" region5

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8N Bacteria
COG0215 LUCA
HOGENOMiHOG000245250
InParanoidiO67163
KOiK01883
OMAiHECEIAQ
OrthoDBiPOG091H004K

Family and domain databases

CDDicd00672 CysRS_core, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00041 Cys_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR015803 Cys-tRNA-ligase
IPR015273 Cys-tRNA-synt_Ia_DALR
IPR024909 Cys-tRNA/MSH_ligase
IPR014729 Rossmann-like_a/b/a_fold
IPR032678 tRNA-synt_1_cat_dom
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR10890 PTHR10890, 1 hit
PfamiView protein in Pfam
PF09190 DALR_2, 1 hit
PF01406 tRNA-synt_1e, 1 hit
PRINTSiPR00983 TRNASYNTHCYS
SMARTiView protein in SMART
SM00840 DALR_2, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
TIGRFAMsiTIGR00435 cysS, 1 hit

Sequencei

Sequence statusi: Complete.

O67163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRIYNTLS GKVEEFVPIN PPKVLIYTCG VTVYDDSHVG HGRSLIVFDV
60 70 80 90 100
FRRFLEHLGY QVKFVRNFTD VDDKIINRAK QECTDFMTIA DRYIARYYVD
110 120 130 140 150
MENIRVRPAD VEPRVTEHIP EIIEVIQKLV EKGYAYVVEG DVYFSVKKFK
160 170 180 190 200
DYGKLSKRDI EELIAGARVE PSEKKRDPLD FALWKASKAG EPAWDSPWGK
210 220 230 240 250
GRPGWHTECV AMVFKHLGET IDIHGGGLDL VFPHHENEIA QAEAITGKPF
260 270 280 290 300
ARYWMHNGLV TVGGQKMSKS LGNYVTLREV YTKYHPDVLR LLVLFTHYRS
310 320 330 340 350
PLDFSWEKME ETLKAYERLK NAIEDLELLK KLQVVESKEG GTHPLYEQVK
360 370 380 390 400
EFEENFYASL SDDFNTPEAL SHVYKLVGEL NKVKNKAYSE GKITDRELSA
410 420 430 440 450
YEFASKSLLN TMKKIFGLLE DLYPECKVER VVERELEAGQ VFDEKLIQIL
460 470 480 490
IEARNIARKE KVFKVADYIR DKLKELGIVL EDTPAGTKWK KREGA
Length:495
Mass (Da):57,136
Last modified:August 1, 1998 - v1
Checksum:iA454658B2BBAE8A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07125.1
PIRiH70391
RefSeqiNP_213726.1, NC_000918.1
WP_010880664.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07125; AAC07125; aq_1068
GeneIDi1193797
KEGGiaae:aq_1068
PATRICifig|224324.8.peg.830

Similar proteinsi

Entry informationi

Entry nameiSYC_AQUAE
AccessioniPrimary (citable) accession number: O67163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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