O67149 (SODC1_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Cu-Zn] 1
EC=1.15.1.1

Gene names

Name:	sodC1
Ordered Locus Names:	aq_1050

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Destroys radicals which are normally produced within the cells and which are toxic to biological systems By similarity.
Catalytic activity	2 superoxide + 2 H+ = O2 + H2O2.
Cofactor	Binds 1 copper ion per subunit By similarity. Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the Cu-Zn superoxide dismutase family.

Ontologies

Keywords
Domain	Signal
Ligand	Copper Metal-binding Zinc
Molecular function	Antioxidant Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	removal of superoxide radicals Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	periplasmic space Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	copper ion binding Inferred from Biological aspect of Ancestor. Source: RefGenome superoxide dismutase activity Inferred from Biological aspect of Ancestor. Source: RefGenome zinc ion binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 169	151	Superoxide dismutase [Cu-Zn] 1		PRO_0000032818
Sites
	Metal binding	65	1	Copper; catalytic By similarity
	Metal binding	67	1	Copper; catalytic By similarity
	Metal binding	83	1	Copper; catalytic By similarity
	Metal binding	83	1	Zinc; structural By similarity
	Metal binding	91	1	Zinc; structural By similarity
	Metal binding	100	1	Zinc; structural By similarity
	Metal binding	103	1	Zinc; structural By similarity
	Metal binding	145	1	Copper; catalytic By similarity
Amino acid modifications
	Disulfide bond	72 ↔ 165		By similarity

Sequences

	Sequence		Length	Mass (Da)
	O67149 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: AA133160A0AF0793	FASTA	169	18,301
	10 20 30 40 50 60 MFEQWDALCA VLFSFSIAQE LKTHADIVNQ KGEKIGKAEL IQTNSGVLIK LEASNLPPNA 70 80 90 100 110 120 ELAFHIHELG KCDPPDFKSA KGHFNPFKKK HGLLNPEGPH AGDMPNIHTD DKGNVRVQVL 130 140 150 160 NPFVTLKKGK KNSLFKEGGT ALVIHGGPDD YKSDPAGNAG KRIACGVVK

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07105.1.
PIR	B70390.
RefSeq	NP_213712.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67149.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193783.
GenomeReviews	Gene locus aq_1050 in contig AE000657_GR.
KEGG	aae:aq_1050.
NMPDR	fig|224324.1.peg.727.
PATRIC	20959382. VBIAquAeo85532_0813.
Phylogenomic databases
HOGENOM	HBG609879.
OMA	NVFANAD.
PhylomeDB	O67149.
ProtClustDB	CLSK233141.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_1050-MONOMER.
Family and domain databases
InterPro	IPR024134. SOD_Cu/Zn_/chaperones. IPR018152. SOD_Cu/Zn_BS. IPR001424. SOD_Cu_Zn_dom. [Graphical view]
Gene3D	G3DSA:2.60.40.200. SOD_Cu_Zn. 1 hit.
KO	K04565.
PANTHER	PTHR10003. SOD_Cu_Zn. 1 hit.
Pfam	PF00080. Sod_Cu. 1 hit. [Graphical view]
SUPFAM	SSF49329. SOD_Cu_Zn. 1 hit.
PROSITE	PS00087. SOD_CU_ZN_1. False negative. PS00332. SOD_CU_ZN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SODC1_AQUAE

Accession

Primary (citable) accession number: O67149

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program