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O67140

- SELA_AQUAE

UniProt

O67140 - SELA_AQUAE

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Protein

L-seryl-tRNA(Sec) selenium transferase

Gene

selA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.UniRule annotation

Catalytic activityi

L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. L-seryl-tRNASec selenium transferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. selenocysteine incorporation Source: UniProtKB-HAMAP
  2. selenocysteinyl-tRNA(Sec) biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Pyridoxal phosphate, Selenium

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-736-MONOMER.
UniPathwayiUPA00906; UER00896.

Names & Taxonomyi

Protein namesi
Recommended name:
L-seryl-tRNA(Sec) selenium transferaseUniRule annotation (EC:2.9.1.1UniRule annotation)
Alternative name(s):
Selenocysteine synthaseUniRule annotation
Short name:
Sec synthaseUniRule annotation
Selenocysteinyl-tRNA(Sec) synthaseUniRule annotation
Gene namesi
Name:selAUniRule annotation
Ordered Locus Names:aq_1031
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 452452L-seryl-tRNA(Sec) selenium transferasePRO_0000189594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_1031.

Structurei

Secondary structure

1
452
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 65Combined sources
Helixi11 – 177Combined sources
Helixi24 – 4320Combined sources
Helixi53 – 6412Combined sources
Beta strandi73 – 775Combined sources
Helixi82 – 843Combined sources
Helixi91 – 10111Combined sources
Beta strandi102 – 1054Combined sources
Turni111 – 1144Combined sources
Helixi119 – 1224Combined sources
Helixi124 – 1318Combined sources
Beta strandi134 – 1407Combined sources
Helixi142 – 15413Combined sources
Beta strandi157 – 1626Combined sources
Helixi163 – 1664Combined sources
Beta strandi167 – 1693Combined sources
Turni170 – 1723Combined sources
Helixi174 – 1807Combined sources
Turni181 – 1833Combined sources
Beta strandi185 – 1917Combined sources
Beta strandi192 – 1943Combined sources
Helixi197 – 2026Combined sources
Beta strandi208 – 2147Combined sources
Beta strandi218 – 2247Combined sources
Helixi230 – 24011Combined sources
Beta strandi244 – 2507Combined sources
Helixi256 – 2594Combined sources
Helixi268 – 2736Combined sources
Beta strandi277 – 2859Combined sources
Beta strandi289 – 2913Combined sources
Beta strandi293 – 2975Combined sources
Helixi299 – 3079Combined sources
Helixi310 – 3134Combined sources
Helixi318 – 33215Combined sources
Helixi336 – 3383Combined sources
Helixi340 – 3456Combined sources
Helixi349 – 36214Combined sources
Turni363 – 3653Combined sources
Beta strandi369 – 37810Combined sources
Beta strandi381 – 3844Combined sources
Beta strandi390 – 40213Combined sources
Helixi404 – 41310Combined sources
Beta strandi414 – 4163Combined sources
Beta strandi418 – 4236Combined sources
Beta strandi426 – 4305Combined sources
Helixi431 – 4333Combined sources
Helixi436 – 4383Combined sources
Helixi439 – 44911Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W1HX-ray3.89A/B/C/D/E1-452[»]
3W1IX-ray3.19A/B/C/D/E/F/G/H/I/J62-452[»]
3W1JX-ray3.25A/B/C/D/E/F/G/H/I/J62-452[»]
3W1KX-ray7.50A/B/C/D/E1-452[»]
3WCNX-ray3.35A/B1-452[»]
3WCOX-ray2.40A/B62-452[»]
ProteinModelPortaliO67140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1921.
HOGENOMiHOG000163726.
InParanoidiO67140.
KOiK01042.
OMAiRCDKVIL.
OrthoDBiEOG69WFGN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00423. SelA.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR018319. SelA-like.
IPR004534. SelA_trans.
[Graphical view]
PfamiPF03841. SelA. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00474. selA. 1 hit.

Sequencei

Sequence statusi: Complete.

O67140-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSLLRQIPQ ISKVVEIFKK KYPEIYVVKA AREVAEKYRK EIIEGKRKDL
60 70 80 90 100
NGFLEDVERK IKSLMKPNIK RVINATGVVI NTNLGRAPLS KDVINFISEI
110 120 130 140 150
ANGYSNLEYN LEEGKRGSRI AHIEKYLNEL TGAESSFVVN NNAGAVFLVL
160 170 180 190 200
NTLAEGKEVI ISRGELVEIG GSFRIPDIMK KSGAILREVG TTNKTKVSDY
210 220 230 240 250
EGAINQNTAL LMKVHKSNFY MEGFVEEVKL EDLVKLGHKY GIPTYYDAGS
260 270 280 290 300
GLLINLKEFG ISVDEPNFRD CISLGIDLVS GSGDKLLGGP QAGIIVGKKN
310 320 330 340 350
LIEKIKKNPI ARALRIDKLT LSGLEMTLKL YFEKRYEDIP VIRMLTQDEK
360 370 380 390 400
ALRQKAKRLE KLLKDIPGLK ISVIKDKAKP GGGSLPELEL PTYCVAIRHD
410 420 430 440 450
RLSSQELSRR LRLAEPPIVC RIREDQLLFD MRTVFHEDLK TIKKTLQELL

SI
Length:452
Mass (Da):50,848
Last modified:August 1, 1998 - v1
Checksum:iE511326E17E9F015
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07094.1.
PIRiA70389.
RefSeqiNP_213703.1. NC_000918.1.
WP_010880641.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07094; AAC07094; aq_1031.
GeneIDi1193774.
KEGGiaae:aq_1031.
PATRICi20959366. VBIAquAeo85532_0805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07094.1 .
PIRi A70389.
RefSeqi NP_213703.1. NC_000918.1.
WP_010880641.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3W1H X-ray 3.89 A/B/C/D/E 1-452 [» ]
3W1I X-ray 3.19 A/B/C/D/E/F/G/H/I/J 62-452 [» ]
3W1J X-ray 3.25 A/B/C/D/E/F/G/H/I/J 62-452 [» ]
3W1K X-ray 7.50 A/B/C/D/E 1-452 [» ]
3WCN X-ray 3.35 A/B 1-452 [» ]
3WCO X-ray 2.40 A/B 62-452 [» ]
ProteinModelPortali O67140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_1031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC07094 ; AAC07094 ; aq_1031 .
GeneIDi 1193774.
KEGGi aae:aq_1031.
PATRICi 20959366. VBIAquAeo85532_0805.

Phylogenomic databases

eggNOGi COG1921.
HOGENOMi HOG000163726.
InParanoidi O67140.
KOi K01042.
OMAi RCDKVIL.
OrthoDBi EOG69WFGN.

Enzyme and pathway databases

UniPathwayi UPA00906 ; UER00896 .
BioCyci AAEO224324:GJBH-736-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00423. SelA.
InterProi IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR018319. SelA-like.
IPR004534. SelA_trans.
[Graphical view ]
Pfami PF03841. SelA. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00474. selA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiSELA_AQUAE
AccessioniPrimary (citable) accession number: O67140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3