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Protein

L-seryl-tRNA(Sec) selenium transferase

Gene

selA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.UniRule annotation

Catalytic activityi

L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: selenocysteinyl-tRNA(Sec) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-seryl-tRNA(Sec) selenium transferase (selA)
This subpathway is part of the pathway selenocysteinyl-tRNA(Sec) biosynthesis, which is itself part of Aminoacyl-tRNA biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route), the pathway selenocysteinyl-tRNA(Sec) biosynthesis and in Aminoacyl-tRNA biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Pyridoxal phosphate, Selenium

Enzyme and pathway databases

UniPathwayiUPA00906; UER00896.

Names & Taxonomyi

Protein namesi
Recommended name:
L-seryl-tRNA(Sec) selenium transferaseUniRule annotation (EC:2.9.1.1UniRule annotation)
Alternative name(s):
Selenocysteine synthaseUniRule annotation
Short name:
Sec synthaseUniRule annotation
Selenocysteinyl-tRNA(Sec) synthaseUniRule annotation
Gene namesi
Name:selAUniRule annotation
Ordered Locus Names:aq_1031
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895941 – 452L-seryl-tRNA(Sec) selenium transferaseAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiO67140.

Interactioni

Protein-protein interaction databases

DIPiDIP-61414N.
STRINGi224324.aq_1031.

Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 6Combined sources5
Helixi11 – 17Combined sources7
Helixi24 – 43Combined sources20
Helixi53 – 64Combined sources12
Beta strandi73 – 77Combined sources5
Helixi82 – 84Combined sources3
Helixi91 – 101Combined sources11
Beta strandi102 – 105Combined sources4
Turni111 – 114Combined sources4
Helixi119 – 122Combined sources4
Helixi124 – 131Combined sources8
Beta strandi134 – 140Combined sources7
Helixi142 – 154Combined sources13
Beta strandi157 – 162Combined sources6
Helixi163 – 166Combined sources4
Beta strandi167 – 169Combined sources3
Turni170 – 172Combined sources3
Helixi174 – 180Combined sources7
Turni181 – 183Combined sources3
Beta strandi185 – 191Combined sources7
Beta strandi192 – 194Combined sources3
Helixi197 – 202Combined sources6
Beta strandi208 – 214Combined sources7
Beta strandi218 – 224Combined sources7
Helixi230 – 240Combined sources11
Beta strandi244 – 250Combined sources7
Helixi256 – 259Combined sources4
Helixi268 – 273Combined sources6
Beta strandi277 – 285Combined sources9
Beta strandi289 – 291Combined sources3
Beta strandi293 – 297Combined sources5
Helixi299 – 307Combined sources9
Helixi310 – 313Combined sources4
Helixi318 – 332Combined sources15
Helixi336 – 338Combined sources3
Helixi340 – 345Combined sources6
Helixi349 – 362Combined sources14
Turni363 – 365Combined sources3
Beta strandi369 – 378Combined sources10
Beta strandi381 – 384Combined sources4
Beta strandi390 – 402Combined sources13
Helixi404 – 413Combined sources10
Beta strandi414 – 416Combined sources3
Beta strandi418 – 423Combined sources6
Beta strandi426 – 430Combined sources5
Helixi431 – 433Combined sources3
Helixi436 – 438Combined sources3
Helixi439 – 449Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W1HX-ray3.89A/B/C/D/E1-452[»]
3W1IX-ray3.19A/B/C/D/E/F/G/H/I/J62-452[»]
3W1JX-ray3.25A/B/C/D/E/F/G/H/I/J62-452[»]
3W1KX-ray7.50A/B/C/D/E1-452[»]
3WCNX-ray3.35A/B1-452[»]
3WCOX-ray2.40A/B62-452[»]
ProteinModelPortaliO67140.
SMRiO67140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1Y. Bacteria.
COG1921. LUCA.
HOGENOMiHOG000163726.
InParanoidiO67140.
KOiK01042.
OMAiNRTHARD.
OrthoDBiPOG091H06BG.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00423. SelA. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR018319. SelA-like.
IPR004534. SelA_trans.
[Graphical view]
PfamiPF03841. SelA. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00474. selA. 1 hit.

Sequencei

Sequence statusi: Complete.

O67140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLRQIPQ ISKVVEIFKK KYPEIYVVKA AREVAEKYRK EIIEGKRKDL
60 70 80 90 100
NGFLEDVERK IKSLMKPNIK RVINATGVVI NTNLGRAPLS KDVINFISEI
110 120 130 140 150
ANGYSNLEYN LEEGKRGSRI AHIEKYLNEL TGAESSFVVN NNAGAVFLVL
160 170 180 190 200
NTLAEGKEVI ISRGELVEIG GSFRIPDIMK KSGAILREVG TTNKTKVSDY
210 220 230 240 250
EGAINQNTAL LMKVHKSNFY MEGFVEEVKL EDLVKLGHKY GIPTYYDAGS
260 270 280 290 300
GLLINLKEFG ISVDEPNFRD CISLGIDLVS GSGDKLLGGP QAGIIVGKKN
310 320 330 340 350
LIEKIKKNPI ARALRIDKLT LSGLEMTLKL YFEKRYEDIP VIRMLTQDEK
360 370 380 390 400
ALRQKAKRLE KLLKDIPGLK ISVIKDKAKP GGGSLPELEL PTYCVAIRHD
410 420 430 440 450
RLSSQELSRR LRLAEPPIVC RIREDQLLFD MRTVFHEDLK TIKKTLQELL

SI
Length:452
Mass (Da):50,848
Last modified:August 1, 1998 - v1
Checksum:iE511326E17E9F015
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07094.1.
PIRiA70389.
RefSeqiNP_213703.1. NC_000918.1.
WP_010880641.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07094; AAC07094; aq_1031.
GeneIDi1193774.
KEGGiaae:aq_1031.
PATRICi20959366. VBIAquAeo85532_0805.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07094.1.
PIRiA70389.
RefSeqiNP_213703.1. NC_000918.1.
WP_010880641.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3W1HX-ray3.89A/B/C/D/E1-452[»]
3W1IX-ray3.19A/B/C/D/E/F/G/H/I/J62-452[»]
3W1JX-ray3.25A/B/C/D/E/F/G/H/I/J62-452[»]
3W1KX-ray7.50A/B/C/D/E1-452[»]
3WCNX-ray3.35A/B1-452[»]
3WCOX-ray2.40A/B62-452[»]
ProteinModelPortaliO67140.
SMRiO67140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61414N.
STRINGi224324.aq_1031.

Proteomic databases

PRIDEiO67140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07094; AAC07094; aq_1031.
GeneIDi1193774.
KEGGiaae:aq_1031.
PATRICi20959366. VBIAquAeo85532_0805.

Phylogenomic databases

eggNOGiENOG4105C1Y. Bacteria.
COG1921. LUCA.
HOGENOMiHOG000163726.
InParanoidiO67140.
KOiK01042.
OMAiNRTHARD.
OrthoDBiPOG091H06BG.

Enzyme and pathway databases

UniPathwayiUPA00906; UER00896.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00423. SelA. 1 hit.
InterProiIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR018319. SelA-like.
IPR004534. SelA_trans.
[Graphical view]
PfamiPF03841. SelA. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00474. selA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSELA_AQUAE
AccessioniPrimary (citable) accession number: O67140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.