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O67140

- SELA_AQUAE

UniProt

O67140 - SELA_AQUAE

Protein

L-seryl-tRNA(Sec) selenium transferase

Gene

selA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.UniRule annotation

    Catalytic activityi

    L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. L-seryl-tRNASec selenium transferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. selenocysteine incorporation Source: UniProtKB-HAMAP
    2. selenocysteinyl-tRNA(Sec) biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate, Selenium

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-736-MONOMER.
    UniPathwayiUPA00906; UER00896.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-seryl-tRNA(Sec) selenium transferaseUniRule annotation (EC:2.9.1.1UniRule annotation)
    Alternative name(s):
    Selenocysteine synthaseUniRule annotation
    Short name:
    Sec synthaseUniRule annotation
    Selenocysteinyl-tRNA(Sec) synthaseUniRule annotation
    Gene namesi
    Name:selAUniRule annotation
    Ordered Locus Names:aq_1031
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 452452L-seryl-tRNA(Sec) selenium transferasePRO_0000189594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei285 – 2851N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_1031.

    Structurei

    Secondary structure

    1
    452
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 65
    Helixi11 – 177
    Helixi24 – 4320
    Helixi53 – 6412
    Beta strandi73 – 775
    Helixi82 – 843
    Helixi91 – 10111
    Beta strandi102 – 1054
    Turni111 – 1144
    Helixi119 – 1224
    Helixi124 – 1318
    Beta strandi134 – 1407
    Helixi142 – 15413
    Beta strandi157 – 1626
    Helixi163 – 1664
    Beta strandi167 – 1693
    Turni170 – 1723
    Helixi174 – 1807
    Turni181 – 1833
    Beta strandi185 – 1917
    Beta strandi192 – 1943
    Helixi197 – 2026
    Beta strandi208 – 2147
    Beta strandi218 – 2247
    Helixi230 – 24011
    Beta strandi244 – 2507
    Helixi256 – 2594
    Helixi268 – 2736
    Beta strandi277 – 2859
    Beta strandi289 – 2913
    Beta strandi293 – 2975
    Helixi299 – 3079
    Helixi310 – 3134
    Helixi318 – 33215
    Helixi336 – 3383
    Helixi340 – 3456
    Helixi349 – 36214
    Turni363 – 3653
    Beta strandi369 – 37810
    Beta strandi381 – 3844
    Beta strandi390 – 40213
    Helixi404 – 41310
    Beta strandi414 – 4163
    Beta strandi418 – 4236
    Beta strandi426 – 4305
    Helixi431 – 4333
    Helixi436 – 4383
    Helixi439 – 44911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3W1HX-ray3.89A/B/C/D/E1-452[»]
    3W1IX-ray3.19A/B/C/D/E/F/G/H/I/J62-452[»]
    3W1JX-ray3.25A/B/C/D/E/F/G/H/I/J62-452[»]
    3W1KX-ray7.50A/B/C/D/E1-452[»]
    3WCNX-ray3.35A/B1-452[»]
    3WCOX-ray2.40A/B62-452[»]
    ProteinModelPortaliO67140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SelA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1921.
    HOGENOMiHOG000163726.
    KOiK01042.
    OMAiRCDKVIL.
    OrthoDBiEOG69WFGN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00423. SelA.
    InterProiIPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR018319. SelA-like.
    IPR004534. SelA_trans.
    [Graphical view]
    PfamiPF03841. SelA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00474. selA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O67140-1 [UniParc]FASTAAdd to Basket

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    MKSLLRQIPQ ISKVVEIFKK KYPEIYVVKA AREVAEKYRK EIIEGKRKDL    50
    NGFLEDVERK IKSLMKPNIK RVINATGVVI NTNLGRAPLS KDVINFISEI 100
    ANGYSNLEYN LEEGKRGSRI AHIEKYLNEL TGAESSFVVN NNAGAVFLVL 150
    NTLAEGKEVI ISRGELVEIG GSFRIPDIMK KSGAILREVG TTNKTKVSDY 200
    EGAINQNTAL LMKVHKSNFY MEGFVEEVKL EDLVKLGHKY GIPTYYDAGS 250
    GLLINLKEFG ISVDEPNFRD CISLGIDLVS GSGDKLLGGP QAGIIVGKKN 300
    LIEKIKKNPI ARALRIDKLT LSGLEMTLKL YFEKRYEDIP VIRMLTQDEK 350
    ALRQKAKRLE KLLKDIPGLK ISVIKDKAKP GGGSLPELEL PTYCVAIRHD 400
    RLSSQELSRR LRLAEPPIVC RIREDQLLFD MRTVFHEDLK TIKKTLQELL 450
    SI 452
    Length:452
    Mass (Da):50,848
    Last modified:August 1, 1998 - v1
    Checksum:iE511326E17E9F015
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07094.1.
    PIRiA70389.
    RefSeqiNP_213703.1. NC_000918.1.
    WP_010880641.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC07094; AAC07094; aq_1031.
    GeneIDi1193774.
    KEGGiaae:aq_1031.
    PATRICi20959366. VBIAquAeo85532_0805.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC07094.1 .
    PIRi A70389.
    RefSeqi NP_213703.1. NC_000918.1.
    WP_010880641.1. NC_000918.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3W1H X-ray 3.89 A/B/C/D/E 1-452 [» ]
    3W1I X-ray 3.19 A/B/C/D/E/F/G/H/I/J 62-452 [» ]
    3W1J X-ray 3.25 A/B/C/D/E/F/G/H/I/J 62-452 [» ]
    3W1K X-ray 7.50 A/B/C/D/E 1-452 [» ]
    3WCN X-ray 3.35 A/B 1-452 [» ]
    3WCO X-ray 2.40 A/B 62-452 [» ]
    ProteinModelPortali O67140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_1031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC07094 ; AAC07094 ; aq_1031 .
    GeneIDi 1193774.
    KEGGi aae:aq_1031.
    PATRICi 20959366. VBIAquAeo85532_0805.

    Phylogenomic databases

    eggNOGi COG1921.
    HOGENOMi HOG000163726.
    KOi K01042.
    OMAi RCDKVIL.
    OrthoDBi EOG69WFGN.

    Enzyme and pathway databases

    UniPathwayi UPA00906 ; UER00896 .
    BioCyci AAEO224324:GJBH-736-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00423. SelA.
    InterProi IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR018319. SelA-like.
    IPR004534. SelA_trans.
    [Graphical view ]
    Pfami PF03841. SelA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00474. selA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiSELA_AQUAE
    AccessioniPrimary (citable) accession number: O67140
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3