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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204L-tryptophanUniRule annotation1
Binding sitei254ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 10ATPUniRule annotation3
Nucleotide bindingi16 – 17ATPUniRule annotation2
Nucleotide bindingi216 – 218ATPUniRule annotation3
Nucleotide bindingi261 – 265ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-705-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:aq_992
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001365981 – 395Tryptophan--tRNA ligaseAdd BLAST395

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_992

Structurei

3D structure databases

ProteinModelPortaliO67115
SMRiO67115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 179InsertAdd BLAST63

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 17"HIGH" regionUniRule annotation9
Motifi261 – 265"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059941
InParanoidiO67115
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

O67115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIVSGMRPT GKLHLGHYFG VIRNWVKLQE EHECFFFIAD WHALTTAYKN
60 70 80 90 100
TKELRQNIRE VMIDWLALGL DPQKSVLFIQ SLVKEHAELF LLFGMITPKS
110 120 130 140 150
WLELNPTYKD LKYNLLRLTD LEKEFKEKLK ERISEIVNLI PFNITKEEKF
160 170 180 190 200
REHLLENLTQ TMIEALFEGE IEPEILKRLN VSKRDFYETD TFGFLGYPVL
210 220 230 240 250
QAADILIYKG EGVPVGEDQL PHIELSREIA RRFNRLYGKI FPEPKALLTE
260 270 280 290 300
TPKIPGTDGR KMSKSYGNAV FFSDEKEEVE KKVMKMFTDP QKIRKNDPGR
310 320 330 340 350
PEICPVFSWH KLFTKDEELV KKIEEDCRAG RLGCVECKRI LLKHLEEFLE
360 370 380 390
PIRERRRELE KRINEIEEVF YENSRKAREI AQKTMEEVRK AMNLP
Length:395
Mass (Da):46,709
Last modified:August 1, 1998 - v1
Checksum:i72345F53CCEFB8F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07073.1
PIRiH70385
RefSeqiNP_213678.1, NC_000918.1
WP_010880616.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07073; AAC07073; aq_992
GeneIDi1193749
KEGGiaae:aq_992
PATRICifig|224324.8.peg.778

Similar proteinsi

Entry informationi

Entry nameiSYW_AQUAE
AccessioniPrimary (citable) accession number: O67115
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health