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Protein

Thymidylate kinase

Gene

tmk

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-695-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:aq_969
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Thymidylate kinasePRO_0000155230Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_969.

Structurei

Secondary structure

1
195
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi13 – 2614Combined sources
Beta strandi31 – 377Combined sources
Helixi41 – 5212Combined sources
Helixi57 – 7418Combined sources
Helixi76 – 816Combined sources
Beta strandi85 – 906Combined sources
Helixi92 – 998Combined sources
Turni100 – 1034Combined sources
Helixi107 – 11812Combined sources
Beta strandi124 – 1307Combined sources
Helixi133 – 1386Combined sources
Turni142 – 1443Combined sources
Helixi149 – 16517Combined sources
Beta strandi166 – 1738Combined sources
Helixi178 – 18912Combined sources
Turni190 – 1923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBRX-ray1.96A/B1-195[»]
4S2EX-ray2.35A/B1-195[»]
4S35X-ray1.55A/B1-195[»]
ProteinModelPortaliO67099.
SMRiO67099. Positions 1-195.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67099.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
InParanoidiO67099.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIAFEGIDG SGKTTQAKKL YEYLKQKGYF VSLYREPGGT KVGEVLREIL
60 70 80 90 100
LTEELDERTE LLLFEASRSK LIEEKIIPDL KRDKVVILDR FVLSTIAYQG
110 120 130 140 150
YGKGLDVEFI KNLNEFATRG VKPDITLLLD IPVDIALRRL KEKNRFENKE
160 170 180 190
FLEKVRKGFL ELAKEEENVV VIDASGEEEE VFKEILRALS GVLRV
Length:195
Mass (Da):22,370
Last modified:August 1, 1998 - v1
Checksum:iF3C2A94D4930956E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07063.1.
PIRiH70383.
RefSeqiNP_213662.1. NC_000918.1.
WP_010880600.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07063; AAC07063; aq_969.
GeneIDi1193641.
KEGGiaae:aq_969.
PATRICi20959280. VBIAquAeo85532_0762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07063.1.
PIRiH70383.
RefSeqiNP_213662.1. NC_000918.1.
WP_010880600.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBRX-ray1.96A/B1-195[»]
4S2EX-ray2.35A/B1-195[»]
4S35X-ray1.55A/B1-195[»]
ProteinModelPortaliO67099.
SMRiO67099. Positions 1-195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07063; AAC07063; aq_969.
GeneIDi1193641.
KEGGiaae:aq_969.
PATRICi20959280. VBIAquAeo85532_0762.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
InParanoidiO67099.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-695-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO67099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiKTHY_AQUAE
AccessioniPrimary (citable) accession number: O67099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.