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Protein

Thymidylate kinase

Gene

tmk

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:aq_969
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001552301 – 195Thymidylate kinaseAdd BLAST195

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_969.

Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Helixi13 – 26Combined sources14
Beta strandi31 – 37Combined sources7
Helixi41 – 52Combined sources12
Helixi57 – 74Combined sources18
Helixi76 – 81Combined sources6
Beta strandi85 – 90Combined sources6
Helixi92 – 99Combined sources8
Turni100 – 103Combined sources4
Helixi107 – 118Combined sources12
Beta strandi124 – 130Combined sources7
Helixi133 – 138Combined sources6
Turni142 – 144Combined sources3
Helixi149 – 165Combined sources17
Beta strandi166 – 173Combined sources8
Helixi178 – 189Combined sources12
Turni190 – 192Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBRX-ray1.96A/B1-195[»]
4S2EX-ray2.35A/B1-195[»]
4S35X-ray1.55A/B1-195[»]
ProteinModelPortaliO67099.
SMRiO67099.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67099.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
InParanoidiO67099.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiPOG091H02B9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIAFEGIDG SGKTTQAKKL YEYLKQKGYF VSLYREPGGT KVGEVLREIL
60 70 80 90 100
LTEELDERTE LLLFEASRSK LIEEKIIPDL KRDKVVILDR FVLSTIAYQG
110 120 130 140 150
YGKGLDVEFI KNLNEFATRG VKPDITLLLD IPVDIALRRL KEKNRFENKE
160 170 180 190
FLEKVRKGFL ELAKEEENVV VIDASGEEEE VFKEILRALS GVLRV
Length:195
Mass (Da):22,370
Last modified:August 1, 1998 - v1
Checksum:iF3C2A94D4930956E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07063.1.
PIRiH70383.
RefSeqiNP_213662.1. NC_000918.1.
WP_010880600.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07063; AAC07063; aq_969.
GeneIDi1193641.
KEGGiaae:aq_969.
PATRICi20959280. VBIAquAeo85532_0762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07063.1.
PIRiH70383.
RefSeqiNP_213662.1. NC_000918.1.
WP_010880600.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBRX-ray1.96A/B1-195[»]
4S2EX-ray2.35A/B1-195[»]
4S35X-ray1.55A/B1-195[»]
ProteinModelPortaliO67099.
SMRiO67099.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07063; AAC07063; aq_969.
GeneIDi1193641.
KEGGiaae:aq_969.
PATRICi20959280. VBIAquAeo85532_0762.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229078.
InParanoidiO67099.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiPOG091H02B9.

Miscellaneous databases

EvolutionaryTraceiO67099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_AQUAE
AccessioniPrimary (citable) accession number: O67099
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.