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Protein
Submitted name:

Hydrogenase small subunit

Gene

mbhS2

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

Protein has several cofactor binding sites:
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi62 – 621Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi157 – 1571Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi191 – 1911Iron-sulfur 1 (4Fe-4S)UniRule annotation
Metal bindingi229 – 2291Iron-sulfur 2 (4Fe-4S); via pros nitrogenUniRule annotation
Metal bindingi232 – 2321Iron-sulfur 2 (4Fe-4S)UniRule annotation
Metal bindingi257 – 2571Iron-sulfur 2 (4Fe-4S)UniRule annotation
Metal bindingi263 – 2631Iron-sulfur 2 (4Fe-4S)UniRule annotation
Metal bindingi272 – 2721Iron-sulfur 3 (3Fe-4S)UniRule annotation
Metal bindingi291 – 2911Iron-sulfur 3 (3Fe-4S)UniRule annotation
Metal bindingi294 – 2941Iron-sulfur 3 (3Fe-4S)UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-691-MONOMER.

Protein family/group databases

TCDBi3.D.7.2.1. the h2:heterodisulfide oxidoreductase (hho) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Hydrogenase small subunitImported
Gene namesi
Name:mbhS2Imported
Ordered Locus Names:aq_965Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_965.

Structurei

3D structure databases

ProteinModelPortaliO67095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 204146Oxidored_q6InterPro annotationAdd
BLAST
Domaini224 – 30279NiFe_hyd_SSU_CInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiENOG4105E3S. Bacteria.
COG1740. LUCA.
HOGENOMiHOG000278822.
InParanoidiO67095.
KOiK06282.
OMAiVEYHEVI.
OrthoDBiEOG6J74S9.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
4.10.480.10. 1 hit.
InterProiIPR027394. Cytochrome-c3_hydrogenase_C.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR001821. NiFe_hydrogenase_ssu.
IPR006311. TAT_signal.
[Graphical view]
PANTHERiPTHR30013. PTHR30013. 1 hit.
PfamiPF14720. NiFe_hyd_SSU_C. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view]
PIRSFiPIRSF000310. NiFe_hyd_ssu. 1 hit.
PRINTSiPR00614. NIHGNASESMLL.
TIGRFAMsiTIGR00391. hydA. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLYEIFKR KGYSRRDFLK FSLAVSAFLG LPPSLYPKVA QALEKKEKPV
60 70 80 90 100
VIWLEFQDCA GCSESFIRST TLLPTEVLLD YISLEYHETL MAPSGFYAEE
110 120 130 140 150
AREEAIKKYK GKYVLVVEGS PTPADGGVYC TVGGKSSVDI LRETAEHAAF
160 170 180 190 200
VIAVGSCASW GGIPKASPNP TGAVPVYEIV KDKPVVNVPG CPPIGDVMVA
210 220 230 240 250
TIVHFLALGK LPPLDELGRP KQFYGETIHD RCYRRAFYNS GQFAESFDDE
260 270 280 290 300
KARKGYCLYK LGCKGPITRN ACASMRWNGG LSFPIQSGHP CFGCSEPDFW
310 320 330 340
DRGFIYNPLS VMEGYSGISD TLKGVGIGAA VGIGIGVLNK LINKKKEEK
Length:349
Mass (Da):38,187
Last modified:August 1, 1998 - v1
Checksum:i577B27B36E52975C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07047.1.
PIRiD70383.
RefSeqiNP_213658.1. NC_000918.1.
WP_010880596.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07047; AAC07047; aq_965.
GeneIDi1193637.
KEGGiaae:aq_965.
PATRICi20959266. VBIAquAeo85532_0755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07047.1.
PIRiD70383.
RefSeqiNP_213658.1. NC_000918.1.
WP_010880596.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_965.

Protein family/group databases

TCDBi3.D.7.2.1. the h2:heterodisulfide oxidoreductase (hho) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07047; AAC07047; aq_965.
GeneIDi1193637.
KEGGiaae:aq_965.
PATRICi20959266. VBIAquAeo85532_0755.

Phylogenomic databases

eggNOGiENOG4105E3S. Bacteria.
COG1740. LUCA.
HOGENOMiHOG000278822.
InParanoidiO67095.
KOiK06282.
OMAiVEYHEVI.
OrthoDBiEOG6J74S9.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-691-MONOMER.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
4.10.480.10. 1 hit.
InterProiIPR027394. Cytochrome-c3_hydrogenase_C.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
IPR001821. NiFe_hydrogenase_ssu.
IPR006311. TAT_signal.
[Graphical view]
PANTHERiPTHR30013. PTHR30013. 1 hit.
PfamiPF14720. NiFe_hyd_SSU_C. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view]
PIRSFiPIRSF000310. NiFe_hyd_ssu. 1 hit.
PRINTSiPR00614. NIHGNASESMLL.
TIGRFAMsiTIGR00391. hydA. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.

Entry informationi

Entry nameiO67095_AQUAE
AccessioniPrimary (citable) accession number: O67095
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.