O67095 (O67095_AQUAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hydrogenase small subunit EMBL AAC07047.1

Gene names

Name:	mbhS2 EMBL AAC07047.1
Ordered Locus Names:	aq_965

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 3Fe-4S cluster By similarity. PIRSR PIRSR000310-1 Binds 2 4Fe-4S clusters By similarity. PIRSR PIRSR000310-1

Ontologies

Keywords
Ligand	3Fe-4S PIRSR PIRSR000310-1 4Fe-4S PIRSR PIRSR000310-1 Iron Iron-sulfur Metal-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	ferredoxin hydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	3 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro ferredoxin hydrogenase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	59	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	62	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	157	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	191	1	Iron-sulfur 1 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	229	1	Iron-sulfur 2 (4Fe-4S); via pros nitrogen By similarity PIRSR PIRSR000310-1
	Metal binding	232	1	Iron-sulfur 2 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	257	1	Iron-sulfur 2 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	263	1	Iron-sulfur 2 (4Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	272	1	Iron-sulfur 3 (3Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	291	1	Iron-sulfur 3 (3Fe-4S) By similarity PIRSR PIRSR000310-1
	Metal binding	294	1	Iron-sulfur 3 (3Fe-4S) By similarity PIRSR PIRSR000310-1

Sequences

	Sequence		Length	Mass (Da)
	O67095 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 577B27B36E52975C	FASTA	349	38,187
	10 20 30 40 50 60 MESLYEIFKR KGYSRRDFLK FSLAVSAFLG LPPSLYPKVA QALEKKEKPV VIWLEFQDCA 70 80 90 100 110 120 GCSESFIRST TLLPTEVLLD YISLEYHETL MAPSGFYAEE AREEAIKKYK GKYVLVVEGS 130 140 150 160 170 180 PTPADGGVYC TVGGKSSVDI LRETAEHAAF VIAVGSCASW GGIPKASPNP TGAVPVYEIV 190 200 210 220 230 240 KDKPVVNVPG CPPIGDVMVA TIVHFLALGK LPPLDELGRP KQFYGETIHD RCYRRAFYNS 250 260 270 280 290 300 GQFAESFDDE KARKGYCLYK LGCKGPITRN ACASMRWNGG LSFPIQSGHP CFGCSEPDFW 310 320 330 340 DRGFIYNPLS VMEGYSGISD TLKGVGIGAA VGIGIGVLNK LINKKKEEK

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07047.1.
PIR	D70383.
RefSeq	NP_213658.1. NC_000918.1.
3D structure databases
HSSP	HSSP built from PDB template 2FRV based on UniProtKB P12943.
ProteinModelPortal	O67095.
ModBase	Search...
Protein family/group databases
TCDB	3.D.7.2.1. H2:heterodisulfide oxidoreductase (HHO) family.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193637.
GenomeReviews	Gene locus aq_965 in contig AE000657_GR.
KEGG	aae:aq_965.
NMPDR	fig|224324.1.peg.673.
PATRIC	20959266. VBIAquAeo85532_0755.
Phylogenomic databases
HOGENOM	HBG575615.
OMA	TRINSKE.
PhylomeDB	O67095.
ProtClustDB	CLSK2748393.
Family and domain databases
InterPro	IPR006137. NADH_UbQ_OxRdtase-like_20kDa. IPR001821. NiFe_hydrogenase_ssu. IPR006311. TAT_signal. [Graphical view]
Gene3D	G3DSA:3.40.50.700. G3DSA:3.40.50.700. 1 hit.
KO	K06282.
Pfam	PF01058. Oxidored_q6. 1 hit. [Graphical view]
PIRSF	PIRSF000310. NiFe_hyd_ssu. 1 hit.
PRINTS	PR00614. NIHGNASESMLL.
TIGRFAMs	TIGR00391. HydA. 1 hit.
PROSITE	PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O67095_AQUAE

Accession

Primary (citable) accession number: O67095

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)