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Protein

Signal peptidase I

Gene

lepB

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32By similarity1
Active sitei75By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-678-MONOMER

Protein family/group databases

MEROPSiS26.025

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:lepB
Ordered Locus Names:aq_955
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001094921 – 256Signal peptidase IAdd BLAST256

Proteomic databases

PRIDEiO67088

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_955

Structurei

3D structure databases

ProteinModelPortaliO67088
SMRiO67088
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Phylogenomic databases

eggNOGiENOG4105C3F Bacteria
COG0681 LUCA
HOGENOMiHOG000003673
InParanoidiO67088
KOiK03100
OMAiENPSYIS
OrthoDBiPOG091H023R

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019757 Pept_S26A_signal_pept_1_Lys-AS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
IPR019533 Peptidase_S26
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PF10502 Peptidase_S26, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00760 SPASE_I_2, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

O67088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKQIVELFL IILAVLFIRE YIAQAYTIPS ASMEPTLLVG DFILVNKLVY
60 70 80 90 100
SLSEPMRGDM IVFKYPKNPD IDFIKRIIAR GGDTVEFFPY YDEKNNVLIY
110 120 130 140 150
KVAVNGKLYE LTYEGEKNYS YDCYQYREKL YREDGEVIQH SVCFRNTLLK
160 170 180 190 200
VPGMVYNAIS SDLCLKYNED GFCVKFVVPE GYYFVMGDNR DNSQDSRFWG
210 220 230 240 250
FVPRENIEGK AFVIYYSGKV PSLTPEEANP LTAVRQIIYA LLNPRPSRIG

KPLIDK
Length:256
Mass (Da):29,676
Last modified:August 1, 1998 - v1
Checksum:iC50B0BB11F0EB4DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07042.1
PIRiE70382
RefSeqiNP_213651.1, NC_000918.1
WP_010880589.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07042; AAC07042; aq_955
GeneIDi1193630
KEGGiaae:aq_955
PATRICifig|224324.8.peg.749

Similar proteinsi

Entry informationi

Entry nameiLEP_AQUAE
AccessioniPrimary (citable) accession number: O67088
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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