Reviewed, UniProtKB/Swiss-Prot O67088 (LEP_AQUAE)

Names and origin

Protein names

Recommended name:
    Signal peptidase I
      Short name=SPase I
    EC=3.4.21.89
Alternative name(s):
    Leader peptidase I

Gene names

Name:	lepB
Ordered Locus Names:	aq_955

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
Sequence similarities	Belongs to the peptidase S26 family.

Ontologies

Keywords
Molecular function	Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	serine-type peptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Signal peptidase I		PRO_0000109492
Sites
	Active site	32	1	By similarity
	Active site	75	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O67088-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: C50B0BB11F0EB4DE	FASTA	256	29,676
	10 20 30 40 50 60 MRKQIVELFL IILAVLFIRE YIAQAYTIPS ASMEPTLLVG DFILVNKLVY SLSEPMRGDM 70 80 90 100 110 120 IVFKYPKNPD IDFIKRIIAR GGDTVEFFPY YDEKNNVLIY KVAVNGKLYE LTYEGEKNYS 130 140 150 160 170 180 YDCYQYREKL YREDGEVIQH SVCFRNTLLK VPGMVYNAIS SDLCLKYNED GFCVKFVVPE 190 200 210 220 230 240 GYYFVMGDNR DNSQDSRFWG FVPRENIEGK AFVIYYSGKV PSLTPEEANP LTAVRQIIYA 250 LLNPRPSRIG KPLIDK

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC07042.1.
PIR	E70382.
RefSeq	NP_213651.1.
3D structure databases
HSSP	HSSP built from PDB template 1B12 based on UniProtKB P00803.
ModBase	Search...
Protein family/group databases
MEROPS	S26.001.
Genome annotation databases
GeneID	1193630.
GenomeReviews	Gene locus aq_955 in contig AE000657_GR.
KEGG	aae:aq_955.
NMPDR	fig|224324.1.peg.666.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O67088.
OMA	O67088. FRIPSNS.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_955-MON.
BRENDA	3.4.21.89. 189781.
Family and domain databases
InterPro	IPR000223. Pept_S26A_signal_pept_1. IPR019758. Pept_S26A_signal_pept_1_CS. IPR019757. Pept_S26A_signal_pept_1_Lys-AS. IPR019756. Pept_S26A_signal_pept_1_Ser-AS. IPR019759. Peptidase_S24_S26_cons-reg. IPR011056. Peptidase_S24_S26A/B/C_b-rbn. [Graphical view]
Gene3D	G3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit.
Pfam	PF00717. Peptidase_S24. 1 hit. [Graphical view]
PRINTS	PR00727. LEADERPTASE.
TIGRFAMs	TIGR02227. sigpep_I_bact. 1 hit.
PROSITE	PS00501. SPASE_I_1. 1 hit. PS00760. SPASE_I_2. 1 hit. PS00761. SPASE_I_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LEP_AQUAE

Accession

Primary (citable) accession number: O67088

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)