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Protein

Glycine--tRNA ligase alpha subunit

Gene

glyQ

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligase alpha subunit (EC:6.1.1.14)
Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name:
GlyRS
Gene namesi
Name:glyQ
Ordered Locus Names:aq_945
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000728251 – 285Glycine--tRNA ligase alpha subunitAdd BLAST285

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi224324.aq_945.

Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 16Combined sources14
Helixi32 – 34Combined sources3
Helixi36 – 39Combined sources4
Beta strandi42 – 46Combined sources5
Beta strandi48 – 57Combined sources10
Helixi59 – 61Combined sources3
Beta strandi72 – 83Combined sources12
Helixi88 – 98Combined sources11
Helixi103 – 105Combined sources3
Beta strandi108 – 117Combined sources10
Helixi118 – 120Combined sources3
Beta strandi122 – 131Combined sources10
Beta strandi134 – 145Combined sources12
Beta strandi155 – 160Combined sources6
Helixi161 – 168Combined sources8
Helixi174 – 176Combined sources3
Beta strandi178 – 180Combined sources3
Helixi185 – 201Combined sources17
Helixi206 – 226Combined sources21
Helixi229 – 248Combined sources20
Helixi254 – 280Combined sources27

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F5WX-ray2.81A/B/C/D/E1-285[»]
ProteinModelPortaliO67081.
SMRiO67081.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QIB. Bacteria.
COG0752. LUCA.
HOGENOMiHOG000264291.
InParanoidiO67081.
KOiK01878.
OMAiLGSYYQF.
OrthoDBiPOG091H01SB.

Family and domain databases

CDDicd00733. GlyRS_alpha_core. 1 hit.
HAMAPiMF_00254. Gly_tRNA_synth_alpha. 1 hit.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFQDIIMTL HKFWAEKGCL IWQPYDVEVG AGTMNPATFL KVLGKKPWNV
60 70 80 90 100
AYVEPSRRPQ DGRYGENPNR LQHYYQFQVI LKPAPRNPQE IYLESLERLG
110 120 130 140 150
INPLEHDIRF VEDDWESPTL GAWGLGWEVW LDGMEITQFT YFQQAGGLDL
160 170 180 190 200
DEISVEITYG LERIAMYIQD KDSVFDIEWK EGITYGEIFK RSEWEWSKYN
210 220 230 240 250
FELADTDMLF QVYEMFEKES KRMVEEGLIF PAYDYLLKCS HVFNILDARG
260 270 280
AISVQERARY IRRMNNLARE IAKLYLQVFE NVGAT
Length:285
Mass (Da):33,672
Last modified:August 1, 1998 - v1
Checksum:i3D5F1F3F10282201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07050.1.
PIRiF70381.
RefSeqiNP_213644.1. NC_000918.1.
WP_010880582.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07050; AAC07050; aq_945.
GeneIDi1193623.
KEGGiaae:aq_945.
PATRICi20959240. VBIAquAeo85532_0742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07050.1.
PIRiF70381.
RefSeqiNP_213644.1. NC_000918.1.
WP_010880582.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5F5WX-ray2.81A/B/C/D/E1-285[»]
ProteinModelPortaliO67081.
SMRiO67081.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07050; AAC07050; aq_945.
GeneIDi1193623.
KEGGiaae:aq_945.
PATRICi20959240. VBIAquAeo85532_0742.

Phylogenomic databases

eggNOGiENOG4107QIB. Bacteria.
COG0752. LUCA.
HOGENOMiHOG000264291.
InParanoidiO67081.
KOiK01878.
OMAiLGSYYQF.
OrthoDBiPOG091H01SB.

Family and domain databases

CDDicd00733. GlyRS_alpha_core. 1 hit.
HAMAPiMF_00254. Gly_tRNA_synth_alpha. 1 hit.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYGA_AQUAE
AccessioniPrimary (citable) accession number: O67081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.