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Protein

Glycine--tRNA ligase alpha subunit

Gene

glyQ

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-677-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine--tRNA ligase alpha subunit (EC:6.1.1.14)
Alternative name(s):
Glycyl-tRNA synthetase alpha subunit
Short name:
GlyRS
Gene namesi
Name:glyQ
Ordered Locus Names:aq_945
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Glycine--tRNA ligase alpha subunitPRO_0000072825Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.By similarity

Protein-protein interaction databases

STRINGi224324.aq_945.

Structurei

Secondary structure

1
285
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1614Combined sources
Helixi32 – 343Combined sources
Helixi36 – 394Combined sources
Beta strandi42 – 465Combined sources
Beta strandi48 – 5710Combined sources
Helixi59 – 613Combined sources
Beta strandi72 – 8312Combined sources
Helixi88 – 9811Combined sources
Helixi103 – 1053Combined sources
Beta strandi108 – 11710Combined sources
Helixi118 – 1203Combined sources
Beta strandi122 – 13110Combined sources
Beta strandi134 – 14512Combined sources
Beta strandi155 – 1606Combined sources
Helixi161 – 1688Combined sources
Helixi174 – 1763Combined sources
Beta strandi178 – 1803Combined sources
Helixi185 – 20117Combined sources
Helixi206 – 22621Combined sources
Helixi229 – 24820Combined sources
Helixi254 – 28027Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5F5WX-ray2.81A/B/C/D/E1-285[»]
ProteinModelPortaliO67081.
SMRiO67081. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QIB. Bacteria.
COG0752. LUCA.
HOGENOMiHOG000264291.
InParanoidiO67081.
KOiK01878.
OMAiLGSYYQF.
OrthoDBiPOG091H01SB.

Family and domain databases

CDDicd00733. GlyRS_alpha_core. 1 hit.
HAMAPiMF_00254. Gly_tRNA_synth_alpha. 1 hit.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFQDIIMTL HKFWAEKGCL IWQPYDVEVG AGTMNPATFL KVLGKKPWNV
60 70 80 90 100
AYVEPSRRPQ DGRYGENPNR LQHYYQFQVI LKPAPRNPQE IYLESLERLG
110 120 130 140 150
INPLEHDIRF VEDDWESPTL GAWGLGWEVW LDGMEITQFT YFQQAGGLDL
160 170 180 190 200
DEISVEITYG LERIAMYIQD KDSVFDIEWK EGITYGEIFK RSEWEWSKYN
210 220 230 240 250
FELADTDMLF QVYEMFEKES KRMVEEGLIF PAYDYLLKCS HVFNILDARG
260 270 280
AISVQERARY IRRMNNLARE IAKLYLQVFE NVGAT
Length:285
Mass (Da):33,672
Last modified:August 1, 1998 - v1
Checksum:i3D5F1F3F10282201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07050.1.
PIRiF70381.
RefSeqiNP_213644.1. NC_000918.1.
WP_010880582.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07050; AAC07050; aq_945.
GeneIDi1193623.
KEGGiaae:aq_945.
PATRICi20959240. VBIAquAeo85532_0742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07050.1.
PIRiF70381.
RefSeqiNP_213644.1. NC_000918.1.
WP_010880582.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5F5WX-ray2.81A/B/C/D/E1-285[»]
ProteinModelPortaliO67081.
SMRiO67081. Positions 1-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07050; AAC07050; aq_945.
GeneIDi1193623.
KEGGiaae:aq_945.
PATRICi20959240. VBIAquAeo85532_0742.

Phylogenomic databases

eggNOGiENOG4107QIB. Bacteria.
COG0752. LUCA.
HOGENOMiHOG000264291.
InParanoidiO67081.
KOiK01878.
OMAiLGSYYQF.
OrthoDBiPOG091H01SB.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-677-MONOMER.

Family and domain databases

CDDicd00733. GlyRS_alpha_core. 1 hit.
HAMAPiMF_00254. Gly_tRNA_synth_alpha. 1 hit.
InterProiIPR006194. Gly-tRNA-synth_heterodimer.
IPR002310. Gly-tRNA_ligase_asu.
[Graphical view]
PfamiPF02091. tRNA-synt_2e. 1 hit.
[Graphical view]
PRINTSiPR01044. TRNASYNTHGA.
TIGRFAMsiTIGR00388. glyQ. 1 hit.
PROSITEiPS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYGA_AQUAE
AccessioniPrimary (citable) accession number: O67081
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.