Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi418Zinc; catalyticCurated1
Active sitei419UniRule annotation1
Metal bindingi422Zinc; catalyticCurated1
Metal bindingi496Zinc; catalyticCurated1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 202ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-667-MONOMER
BRENDAi3.4.24.B17 396

Protein family/group databases

MEROPSiM41.001

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ftsHUniRule annotation
Ordered Locus Names:aq_936
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicUniRule annotation5
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Topological domaini27 – 100PeriplasmicUniRule annotationAdd BLAST74
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Topological domaini122 – 634CytoplasmicUniRule annotationAdd BLAST513

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846251 – 634ATP-dependent zinc metalloprotease FtsHAdd BLAST634

Proteomic databases

PRIDEiO67077

Interactioni

Subunit structurei

The isolated protease domain (residues 405-634) forms a stable hexamer.1 Publication

Protein-protein interaction databases

STRINGi224324.aq_936

Structurei

Secondary structure

1634
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi145 – 149Combined sources5
Helixi154 – 156Combined sources3
Helixi161 – 166Combined sources6
Helixi168 – 175Combined sources8
Helixi177 – 181Combined sources5
Turni182 – 184Combined sources3
Beta strandi189 – 194Combined sources6
Helixi201 – 212Combined sources12
Beta strandi216 – 220Combined sources5
Helixi221 – 223Combined sources3
Beta strandi227 – 229Combined sources3
Helixi231 – 246Combined sources16
Beta strandi248 – 254Combined sources7
Helixi256 – 259Combined sources4
Helixi275 – 288Combined sources14
Helixi291 – 293Combined sources3
Beta strandi295 – 302Combined sources8
Helixi304 – 306Combined sources3
Helixi309 – 312Combined sources4
Beta strandi319 – 322Combined sources4
Helixi328 – 339Combined sources12
Beta strandi340 – 342Combined sources3
Helixi350 – 355Combined sources6
Helixi362 – 379Combined sources18
Beta strandi382 – 384Combined sources3
Helixi386 – 394Combined sources9
Helixi409 – 428Combined sources20
Beta strandi429 – 431Combined sources3
Beta strandi438 – 440Combined sources3
Helixi463 – 488Combined sources26
Helixi491 – 493Combined sources3
Helixi494 – 509Combined sources16
Turni515 – 517Combined sources3
Helixi541 – 568Combined sources28
Helixi570 – 583Combined sources14
Beta strandi584 – 586Combined sources3
Helixi588 – 598Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI4X-ray2.79A/B405-634[»]
4WW0X-ray2.96A/B/C141-634[»]
4Z8XX-ray3.25A/B/C142-634[»]
ProteinModelPortaliO67077
SMRiO67077
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67077

Family & Domainsi

Sequence similaritiesi

In the central section; belongs to the AAA ATPase family.UniRule annotation
In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3H Bacteria
COG0465 LUCA
HOGENOMiHOG000217276
InParanoidiO67077
KOiK03798
OMAiMNKRWRN
OrthoDBiPOG091H02HH

Family and domain databases

HAMAPiMF_01458 FtsH, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR005936 FtsH
IPR027417 P-loop_NTPase
IPR011546 Pept_M41_FtsH_extracell
IPR000642 Peptidase_M41
IPR037219 Peptidase_M41-like
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF06480 FtsH_ext, 1 hit
PF01434 Peptidase_M41, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF140990 SSF140990, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01241 FtsH_fam, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

O67077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALKNFFIW AIIIGAAIVA FNLFEGKREF TTKVSLNEVV KLVEEGKVSY
60 70 80 90 100
AEVRGNTAII QTKDGQKLEV TLPPNTNLVD KMVEKGVRVE VANPEPPGGW
110 120 130 140 150
LVNVFLSWLP ILFFIGIWIF LLRQMSGGGN VNRAFNFGKS RAKVYIEEKP
160 170 180 190 200
KVTFKDVAGI EEVKEEVKEI IEYLKDPVKF QKLGGRPPKG VLLYGEPGVG
210 220 230 240 250
KTLLAKAIAG EAHVPFISVS GSDFVEMFVG VGAARVRDLF ETAKKHAPCI
260 270 280 290 300
IFIDEIDAVG RARGAIPVGG GHDEREQTLN QLLVEMDGFD TSDGIIVIAA
310 320 330 340 350
TNRPDILDPA LLRPGRFDRQ IFIPKPDVRG RYEILKVHAR NKKLAKDVDL
360 370 380 390 400
EFVARATPGF TGADLENLLN EAALLAARKG KEEITMEEIE EALDRITMGL
410 420 430 440 450
ERKGMTISPK EKEKIAIHEA GHALMGLVSD DDDKVHKISI IPRGMALGVT
460 470 480 490 500
QQLPIEDKHI YDKKDLYNKI LVLLGGRAAE EVFFGKDGIT TGAENDLQRA
510 520 530 540 550
TDLAYRMVSM WGMSDKVGPI AIRRVANPFL GGMTTAVDTS PDLLREIDEE
560 570 580 590 600
VKRIITEQYE KAKAIVEEYK EPLKAVVKKL LEKETITCEE FVEVFKLYGI
610 620 630
ELKDKCKKEE LFDKDRKSEE NKELKSEEVK EEVV
Length:634
Mass (Da):70,686
Last modified:August 1, 1998 - v1
Checksum:i320D4A6B3F58AA53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC07029.1
PIRiB70381
RefSeqiNP_213640.1, NC_000918.1
WP_010880578.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC07029; AAC07029; aq_936
GeneIDi1193619
KEGGiaae:aq_936
PATRICifig|224324.8.peg.734

Similar proteinsi

Entry informationi

Entry nameiFTSH_AQUAE
AccessioniPrimary (citable) accession number: O67077
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health