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Protein

ATP-dependent zinc metalloprotease FtsH

Gene

ftsH

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.UniRule annotation

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi418 – 4181Zinc; catalyticCurated
Active sitei419 – 4191UniRule annotation
Metal bindingi422 – 4221Zinc; catalyticCurated
Metal bindingi496 – 4961Zinc; catalyticCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 2028ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-673-MONOMER.
BRENDAi3.4.24.B17. 396.

Protein family/group databases

MEROPSiM41.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease FtsHUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:ftsHUniRule annotation
Ordered Locus Names:aq_936
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 55CytoplasmicUniRule annotation
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Topological domaini27 – 10074PeriplasmicUniRule annotationAdd
BLAST
Transmembranei101 – 12121HelicalUniRule annotationAdd
BLAST
Topological domaini122 – 634513CytoplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634ATP-dependent zinc metalloprotease FtsHPRO_0000084625Add
BLAST

Interactioni

Subunit structurei

The isolated protease domain (residues 405-634) forms a stable hexamer.1 Publication

Protein-protein interaction databases

STRINGi224324.aq_936.

Structurei

Secondary structure

1
634
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi145 – 1495Combined sources
Helixi154 – 1563Combined sources
Helixi161 – 1666Combined sources
Helixi168 – 1758Combined sources
Helixi177 – 1815Combined sources
Turni182 – 1843Combined sources
Beta strandi189 – 1946Combined sources
Helixi201 – 21212Combined sources
Beta strandi216 – 2205Combined sources
Helixi221 – 2233Combined sources
Beta strandi227 – 2293Combined sources
Helixi231 – 24616Combined sources
Beta strandi248 – 2547Combined sources
Helixi256 – 2594Combined sources
Helixi275 – 28814Combined sources
Helixi291 – 2933Combined sources
Beta strandi295 – 3028Combined sources
Helixi304 – 3063Combined sources
Helixi309 – 3124Combined sources
Beta strandi319 – 3224Combined sources
Helixi328 – 33912Combined sources
Beta strandi340 – 3423Combined sources
Helixi350 – 3556Combined sources
Helixi362 – 37918Combined sources
Beta strandi382 – 3843Combined sources
Helixi386 – 3949Combined sources
Helixi409 – 42820Combined sources
Beta strandi429 – 4313Combined sources
Beta strandi438 – 4403Combined sources
Helixi463 – 48826Combined sources
Helixi491 – 4933Combined sources
Helixi494 – 50916Combined sources
Turni515 – 5173Combined sources
Helixi541 – 56828Combined sources
Helixi570 – 58314Combined sources
Beta strandi584 – 5863Combined sources
Helixi588 – 59811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DI4X-ray2.79A/B405-634[»]
4WW0X-ray2.96A/B/C141-634[»]
4Z8XX-ray3.25A/B/C142-634[»]
ProteinModelPortaliO67077.
SMRiO67077. Positions 141-594.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67077.

Family & Domainsi

Sequence similaritiesi

In the central section; belongs to the AAA ATPase family.UniRule annotation
In the C-terminal section; belongs to the peptidase M41 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C3H. Bacteria.
COG0465. LUCA.
HOGENOMiHOG000217276.
InParanoidiO67077.
KOiK03798.
OMAiIAMITSF.
OrthoDBiPOG091H02HH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67077-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALKNFFIW AIIIGAAIVA FNLFEGKREF TTKVSLNEVV KLVEEGKVSY
60 70 80 90 100
AEVRGNTAII QTKDGQKLEV TLPPNTNLVD KMVEKGVRVE VANPEPPGGW
110 120 130 140 150
LVNVFLSWLP ILFFIGIWIF LLRQMSGGGN VNRAFNFGKS RAKVYIEEKP
160 170 180 190 200
KVTFKDVAGI EEVKEEVKEI IEYLKDPVKF QKLGGRPPKG VLLYGEPGVG
210 220 230 240 250
KTLLAKAIAG EAHVPFISVS GSDFVEMFVG VGAARVRDLF ETAKKHAPCI
260 270 280 290 300
IFIDEIDAVG RARGAIPVGG GHDEREQTLN QLLVEMDGFD TSDGIIVIAA
310 320 330 340 350
TNRPDILDPA LLRPGRFDRQ IFIPKPDVRG RYEILKVHAR NKKLAKDVDL
360 370 380 390 400
EFVARATPGF TGADLENLLN EAALLAARKG KEEITMEEIE EALDRITMGL
410 420 430 440 450
ERKGMTISPK EKEKIAIHEA GHALMGLVSD DDDKVHKISI IPRGMALGVT
460 470 480 490 500
QQLPIEDKHI YDKKDLYNKI LVLLGGRAAE EVFFGKDGIT TGAENDLQRA
510 520 530 540 550
TDLAYRMVSM WGMSDKVGPI AIRRVANPFL GGMTTAVDTS PDLLREIDEE
560 570 580 590 600
VKRIITEQYE KAKAIVEEYK EPLKAVVKKL LEKETITCEE FVEVFKLYGI
610 620 630
ELKDKCKKEE LFDKDRKSEE NKELKSEEVK EEVV
Length:634
Mass (Da):70,686
Last modified:August 1, 1998 - v1
Checksum:i320D4A6B3F58AA53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07029.1.
PIRiB70381.
RefSeqiNP_213640.1. NC_000918.1.
WP_010880578.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07029; AAC07029; aq_936.
GeneIDi1193619.
KEGGiaae:aq_936.
PATRICi20959224. VBIAquAeo85532_0734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07029.1.
PIRiB70381.
RefSeqiNP_213640.1. NC_000918.1.
WP_010880578.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DI4X-ray2.79A/B405-634[»]
4WW0X-ray2.96A/B/C141-634[»]
4Z8XX-ray3.25A/B/C142-634[»]
ProteinModelPortaliO67077.
SMRiO67077. Positions 141-594.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_936.

Protein family/group databases

MEROPSiM41.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07029; AAC07029; aq_936.
GeneIDi1193619.
KEGGiaae:aq_936.
PATRICi20959224. VBIAquAeo85532_0734.

Phylogenomic databases

eggNOGiENOG4105C3H. Bacteria.
COG0465. LUCA.
HOGENOMiHOG000217276.
InParanoidiO67077.
KOiK03798.
OMAiIAMITSF.
OrthoDBiPOG091H02HH.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-673-MONOMER.
BRENDAi3.4.24.B17. 396.

Miscellaneous databases

EvolutionaryTraceiO67077.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSH_AQUAE
AccessioniPrimary (citable) accession number: O67077
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.