O67068 (SYR_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	aq_923

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000151524
Regions
	Motif	121 – 131	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	O67068 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 350807CA39C1220B	FASTA	583	68,319
	10 20 30 40 50 60 MKELVKEKVL KALKELYNTQ VENFKVEKPK EEAHGDLASN VAFLLARELK KPPVNIAQEL 70 80 90 100 110 120 ADFLSKDETF KSVEAVKGFI NFRFSEDFLK EEFKKFLLSG EAYFKEDLGK GLKVQLEYVS 130 140 150 160 170 180 ANPTGPLHLG HGRGAVVGDT LARLFKFFNY DVTREYYIND AGRQVYLLGI SIYYRYLEKC 190 200 210 220 230 240 PERDEETFKE IKEIFEKDGY RGEYVKEIAE RLRKLVGESL CKPEEANLKE VREKILKEES 250 260 270 280 290 300 IELYYTKKYE PKDVVDLLSN YGLDLMMKEI REDLSLMDIS FDVWFSERSL YDSGEVERLI 310 320 330 340 350 360 NLLKEKGYVY EKDGALWLKT SLFGDDKDRV VKRSDGTYTY FASDIAYHYN KFKRGFEKVI 370 380 390 400 410 420 NVWGADHHGY IPRVKAALKM LEIPEDWLEI LLVQMVKLFR EGKEVKMSKR AGTFVTLREL 430 440 450 460 470 480 LDEVGKDAVR FIFLTKRSDT PLDFDVEKAK EKSSENPVYY VQYAHARISG IFREFKERYK 490 500 510 520 530 540 KDVSVEELIN YVQHLEEEAE IKLIKKVLFF KDELVDITLK REPHLLTYYL IDLAGDFHHY 550 560 570 580 YNHHRILGME ENVMFSRLAL VKGIKEVVRL GLNLMGVSAP ERM

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07033.1.
PIR	A70380.
RefSeq	NP_213630.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67068.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193610.
GenomeReviews	Gene locus aq_923 in contig AE000657_GR.
KEGG	aae:aq_923.
NMPDR	fig|224324.1.peg.645.
PATRIC	20959200. VBIAquAeo85532_0723.
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FDVYFHE.
PhylomeDB	O67068.
ProtClustDB	CLSK2748384.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_923-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_AQUAE

Accession

Primary (citable) accession number: O67068

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program