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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:aq_923
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001515241 – 583Arginine--tRNA ligaseAdd BLAST583

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_923.

Structurei

3D structure databases

ProteinModelPortaliO67068.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi121 – 131"HIGH" regionAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C75. Bacteria.
COG0018. LUCA.
HOGENOMiHOG000247214.
InParanoidiO67068.
KOiK01887.
OMAiNKPLHLG.
OrthoDBiPOG091H01RF.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR036695. Arg-tRNA-synth_N_sf.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

O67068-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELVKEKVL KALKELYNTQ VENFKVEKPK EEAHGDLASN VAFLLARELK
60 70 80 90 100
KPPVNIAQEL ADFLSKDETF KSVEAVKGFI NFRFSEDFLK EEFKKFLLSG
110 120 130 140 150
EAYFKEDLGK GLKVQLEYVS ANPTGPLHLG HGRGAVVGDT LARLFKFFNY
160 170 180 190 200
DVTREYYIND AGRQVYLLGI SIYYRYLEKC PERDEETFKE IKEIFEKDGY
210 220 230 240 250
RGEYVKEIAE RLRKLVGESL CKPEEANLKE VREKILKEES IELYYTKKYE
260 270 280 290 300
PKDVVDLLSN YGLDLMMKEI REDLSLMDIS FDVWFSERSL YDSGEVERLI
310 320 330 340 350
NLLKEKGYVY EKDGALWLKT SLFGDDKDRV VKRSDGTYTY FASDIAYHYN
360 370 380 390 400
KFKRGFEKVI NVWGADHHGY IPRVKAALKM LEIPEDWLEI LLVQMVKLFR
410 420 430 440 450
EGKEVKMSKR AGTFVTLREL LDEVGKDAVR FIFLTKRSDT PLDFDVEKAK
460 470 480 490 500
EKSSENPVYY VQYAHARISG IFREFKERYK KDVSVEELIN YVQHLEEEAE
510 520 530 540 550
IKLIKKVLFF KDELVDITLK REPHLLTYYL IDLAGDFHHY YNHHRILGME
560 570 580
ENVMFSRLAL VKGIKEVVRL GLNLMGVSAP ERM
Length:583
Mass (Da):68,319
Last modified:August 1, 1998 - v1
Checksum:i350807CA39C1220B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07033.1.
PIRiA70380.
RefSeqiNP_213630.1. NC_000918.1.
WP_010880568.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07033; AAC07033; aq_923.
GeneIDi1193610.
KEGGiaae:aq_923.
PATRICifig|224324.8.peg.723.

Similar proteinsi

Entry informationi

Entry nameiSYR_AQUAE
AccessioniPrimary (citable) accession number: O67068
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families