Reviewed, UniProtKB/Swiss-Prot O67061 (DAPB_AQUAE)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	aq_916

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141407

Sequences

	Sequence		Length	Mass (Da)
	O67061-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: EC3240CBCE8BE27A	FASTA	265	28,961
	10 20 30 40 50 60 MSVRVVVCGA LGRMGRRIIE LALQDKDVEV VGGVEHPDCV PSIDLGEALG KEELKGKPLT 70 80 90 100 110 120 SRLEELLPYT DVVIEFSGNP TAAVGHAELT TLEKKAIVIG TTGFTKQEIE QIKEFSKNAP 130 140 150 160 170 180 VLLSPNMSLG VNLLFKLAEI AAKVLKDKNF DAEIMEIHHR FKKDAPSGTA MKLAEILSET 190 200 210 220 230 240 LEKKNLVFGR KGEAPRKEDE IGVMALRGGD VVGDHTVYFL GFGERIELTH RATSRDTFAK 250 260 GAVEAAKWIK GKEPGFYTMF DVLGL

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC07008.1.
PIR	B70379.
RefSeq	NP_213623.1.
3D structure databases
HSSP	HSSP built from PDB template 1DRW based on UniProtKB P04036.
ModBase	Search...
Genome annotation databases
GeneID	1193603.
GenomeReviews	Gene locus aq_916 in contig AE000657_GR.
KEGG	aae:aq_916.
NMPDR	fig|224324.1.peg.638.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O67061.
OMA	O67061. EVLTISH.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_916-MON.
BRENDA	1.3.1.26. 189781.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. DapB_bac/pln. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_AQUAE

Accession

Primary (citable) accession number: O67061

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)