O67055 (PPNK_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	aq_909

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120590

Sequences

	Sequence		Length	Mass (Da)
	O67055 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 34510F2B30EE82C6	FASTA	274	31,327
	10 20 30 40 50 60 MRKVLVFLKN SKKAFETFKR VERVLKDLNL SYKKFINRKE LFKVLKPKDY ELFLVIGGDG 70 80 90 100 110 120 TFLSAARIAS RFGVPLVGVN EGRFGFLTEI KKEEIKKVLP LVLEGRAKLQ ERLMIDVYLR 130 140 150 160 170 180 SRNRLRYLGN YLNDAVISKS SIARIIRTKV FINGEEVLEV FGDGVILSTP TGSTAYALSA 190 200 210 220 230 240 GGPIVYPESQ NLLFVPICPH TLSNRPLVLP SKFEVKFKVV SENMEAFLTL DGQEGFHLKK 250 260 270 GDEVIVKRSR YVCRMYSHPR KSFFGILKEK LRWG

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC07026.1.
PIR	D70378.
RefSeq	NP_213617.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O67055.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193597.
GenomeReviews	Gene locus aq_909 in contig AE000657_GR.
KEGG	aae:aq_909.
NMPDR	fig|224324.1.peg.632.
PATRIC	20959172. VBIAquAeo85532_0709.
Phylogenomic databases
HOGENOM	HBG713904.
OMA	KLGWGLP.
PhylomeDB	O67055.
ProtClustDB	CLSK2299545.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_909-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_AQUAE

Accession

Primary (citable) accession number: O67055

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program