ID   AROE_AQUAE              Reviewed;         269 AA.
AC   O67049;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=aq_901;
OS   Aquifex aeolicus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=63363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AE000657; AAC07007.1; -; Genomic_DNA.
DR   PIR; F70377; F70377.
DR   RefSeq; NP_213611.1; -.
DR   PDB; 2HK7; X-ray; 2.50 A; A/B=1-269.
DR   PDB; 2HK8; X-ray; 2.35 A; A/B/C/D/E/F/G/H=1-269.
DR   PDB; 2HK9; X-ray; 2.20 A; A/B/C/D=1-269.
DR   PDBsum; 2HK7; -.
DR   PDBsum; 2HK8; -.
DR   PDBsum; 2HK9; -.
DR   GeneID; 1193591; -.
DR   GenomeReviews; AE000657_GR; aq_901.
DR   KEGG; aae:aq_901; -.
DR   NMPDR; fig|224324.1.peg.626; -.
DR   HOGENOM; O67049; -.
DR   OMA; O67049; DAPGFLE.
DR   BioCyc; AAEO224324:AQ_901-MON; -.
DR   BRENDA; 1.1.1.25; 189781.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amino-acid biosynthesis;
KW   Aromatic amino acid biosynthesis; Complete proteome; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    269       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135990.
FT   NP_BIND     130    134       NADP (By similarity).
FT   ACT_SITE     70     70       Proton acceptor (Potential).
SQ   SEQUENCE   269 AA;  30106 MW;  3F2E5E490FB9ADB7 CRC64;
     MINAQTQLYG VIGFPVKHSL SPVFQNALIR YAGLNAVYLA FEINPEELKK AFEGFKALKV
     KGINVTVPFK EEIIPLLDYV EDTAKEIGAV NTVKFENGKA YGYNTDWIGF LKSLKSLIPE
     VKEKSILVLG AGGASRAVIY ALVKEGAKVF LWNRTKEKAI KLAQKFPLEV VNSPEEVIDK
     VQVIVNTTSV GLKDKDPEIF NYDLIKKDHV VVDIIYKETK LLKKAKEKGA KLFDGLPMLL
     WQGIEAFKIW NGCEVPYSVA ERSVRDLRG
//