Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O67012

- SPOT_AQUAE

UniProt

O67012 - SPOT_AQUAE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Gene

spoT

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity).By similarity

Catalytic activityi

Guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.

Cofactori

Manganese.By similarity

Pathwayi

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-603-MONOMER.
UniPathwayiUPA00908; UER00886.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (EC:3.1.7.2)
Alternative name(s):
Penta-phosphate guanosine-3'-pyrophosphohydrolase
Short name:
(ppGpp)ase
Gene namesi
Name:spoT
Ordered Locus Names:aq_844
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolasePRO_0000166567Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_844.

Structurei

3D structure databases

ProteinModelPortaliO67012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 14597HDAdd
BLAST
Domaini623 – 69674ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RelA/SpoT family.Curated
Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 HD domain.Curated

Phylogenomic databases

eggNOGiCOG0317.
HOGENOMiHOG000018299.
InParanoidiO67012.
KOiK01139.
OMAiIGYITRG.
OrthoDBiEOG6SV551.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
SMARTiSM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view]
SUPFAMiSSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00691. spoT_relA. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67012-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLGEVSLE EDLEKLLSHY PQHAEEIQRA YEFAKEKHGE QKRKTGEPYI
60 70 80 90 100
IHPLNVALKL AELGMDHETI IAALLHDTLE DTDTTYEEIK ERFGERVAKL
110 120 130 140 150
VEGVTKIGKI KYKSEQAENY RKLILATAED PRVILLKLSD RLDNVKTLWV
160 170 180 190 200
FREEKRKKIA KETMEIYAPL AHRLGVWSIK NELEDWAFKY LYPEEYEKVR
210 220 230 240 250
NFVKESRKNL EEYLRKYVIP KVRKELEKYG IEAEIKYRSK HYYSIWEKTR
260 270 280 290 300
RKGIRLEDVH DILGVRIIVN TVPECYTVLG IIHSLFRPVP GKFKDYISLP
310 320 330 340 350
KPNLYQSLHT TVIADKGKLV EFQIRTWEMH ERAEKGIASH WAYKEGKNPS
360 370 380 390 400
DAGVYSWLRE LVESIQGSTN PSEVLENLKS NLFFEEVFVF TPKGDLVVLP
410 420 430 440 450
KGSTPVDLAY KIHTEVGNHC AGAKSNGRIV PLNYELKSGD VVEIITNPNK
460 470 480 490 500
SPSYEWLSFV KTSRARNKIK QFLKKQERER YLSEGKRILE RIREKLGLSH
510 520 530 540 550
EDLINKIRER VRFDTEEELL LALGKRKISS ANLIKLIFPK KKEEKEERRG
560 570 580 590 600
SSTVFLEDLS NIKHEVAKCC KPIPGDEILG VITRTKGLVL HEKSCSNLKN
610 620 630 640 650
VLRLNPEKVK EVQLQASGYF QTDIRVVASD RIGLLSDITK VISESGSNIV
660 670 680 690
SSMTNTREGK AVMDFTVEVK NKEHLEKIMK KIKSVEGVKI CKRLYH
Length:696
Mass (Da):80,570
Last modified:August 1, 1998 - v1
Checksum:i825F3FE6A556FF15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06975.1.
PIRiA70373.
RefSeqiNP_213573.1. NC_000918.1.
WP_010880511.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06975; AAC06975; aq_844.
GeneIDi1193554.
KEGGiaae:aq_844.
PATRICi20959066. VBIAquAeo85532_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06975.1 .
PIRi A70373.
RefSeqi NP_213573.1. NC_000918.1.
WP_010880511.1. NC_000918.1.

3D structure databases

ProteinModelPortali O67012.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06975 ; AAC06975 ; aq_844 .
GeneIDi 1193554.
KEGGi aae:aq_844.
PATRICi 20959066. VBIAquAeo85532_0658.

Phylogenomic databases

eggNOGi COG0317.
HOGENOMi HOG000018299.
InParanoidi O67012.
KOi K01139.
OMAi IGYITRG.
OrthoDBi EOG6SV551.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00886 .
BioCyci AAEO224324:GJBH-603-MONOMER.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR002912. ACT_dom.
IPR012675. Beta-grasp_dom.
IPR003607. HD/PDEase_dom.
IPR006674. HD_domain.
IPR004811. RelA/Spo_fam.
IPR007685. RelA_SpoT.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF01966. HD. 1 hit.
PF04607. RelA_SpoT. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view ]
SMARTi SM00471. HDc. 1 hit.
SM00954. RelA_SpoT. 1 hit.
[Graphical view ]
SUPFAMi SSF81271. SSF81271. 1 hit.
TIGRFAMsi TIGR00691. spoT_relA. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiSPOT_AQUAE
AccessioniPrimary (citable) accession number: O67012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3