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Protein

5'-nucleotidase SurE

Gene

surE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Divalent metal cationUniRule annotation
Metal bindingi10 – 101Divalent metal cationUniRule annotation
Metal bindingi40 – 401Divalent metal cationUniRule annotation
Metal bindingi94 – 941Divalent metal cationUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:aq_832
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2512515'-nucleotidase SurEPRO_0000111788Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_832.

Structurei

Secondary structure

1
251
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 75Combined sources
Helixi15 – 2410Combined sources
Turni25 – 273Combined sources
Beta strandi28 – 3710Combined sources
Beta strandi52 – 587Combined sources
Beta strandi61 – 644Combined sources
Helixi69 – 7810Combined sources
Turni79 – 835Combined sources
Beta strandi87 – 9610Combined sources
Helixi100 – 1056Combined sources
Helixi107 – 11711Combined sources
Beta strandi122 – 1287Combined sources
Beta strandi130 – 1323Combined sources
Helixi135 – 15218Combined sources
Beta strandi158 – 16710Combined sources
Helixi169 – 1713Combined sources
Beta strandi174 – 1774Combined sources
Beta strandi184 – 19310Combined sources
Beta strandi199 – 2079Combined sources
Turni208 – 2114Combined sources
Helixi217 – 2226Combined sources
Beta strandi225 – 2339Combined sources
Helixi238 – 24811Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQKX-ray1.50A/B1-251[»]
ProteinModelPortaliO67004.
SMRiO67004. Positions 2-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
InParanoidiO67004.
KOiK03787.
OMAiNLNIPPC.
OrthoDBiEOG68WR45.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

O67004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFLLVNDD GYFSPGINAL REALKSLGRV VVVAPDRNLS GVGHSLTFTE
60 70 80 90 100
PLKMRKIDTD FYTVIDGTPA DCVHLGYRVI LEEKKPDLVL SGINEGPNLG
110 120 130 140 150
EDITYSGTVS GAMEGRILGI PSIAFSAFGR ENIMFEEIAK VCVDIVKKVL
160 170 180 190 200
NEGIPEDTYL NVNIPNLRYE EIKGIKVTRQ GKRAYKERVF KYIDPYGKPF
210 220 230 240 250
YWIAAEEFGW HAEEGTDYWA VLNGYVSVTP LHLDLTNYKV MKSIKYLEDS

P
Length:251
Mass (Da):28,165
Last modified:August 1, 1998 - v1
Checksum:i7D36DDD8BEB1C55B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06967.1.
PIRiA70372.
RefSeqiNP_213565.1. NC_000918.1.
WP_010880503.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06967; AAC06967; aq_832.
GeneIDi1193454.
KEGGiaae:aq_832.
PATRICi20959050. VBIAquAeo85532_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06967.1.
PIRiA70372.
RefSeqiNP_213565.1. NC_000918.1.
WP_010880503.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQKX-ray1.50A/B1-251[»]
ProteinModelPortaliO67004.
SMRiO67004. Positions 2-249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06967; AAC06967; aq_832.
GeneIDi1193454.
KEGGiaae:aq_832.
PATRICi20959050. VBIAquAeo85532_0650.

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
InParanoidiO67004.
KOiK03787.
OMAiNLNIPPC.
OrthoDBiEOG68WR45.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-595-MONOMER.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiSURE_AQUAE
AccessioniPrimary (citable) accession number: O67004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.