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Protein

5'-nucleotidase SurE

Gene

surE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi10Divalent metal cationUniRule annotation1
Metal bindingi40Divalent metal cationUniRule annotation1
Metal bindingi94Divalent metal cationUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation)
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:aq_832
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001117881 – 2515'-nucleotidase SurEAdd BLAST251

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_832.

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi15 – 24Combined sources10
Turni25 – 27Combined sources3
Beta strandi28 – 37Combined sources10
Beta strandi52 – 58Combined sources7
Beta strandi61 – 64Combined sources4
Helixi69 – 78Combined sources10
Turni79 – 83Combined sources5
Beta strandi87 – 96Combined sources10
Helixi100 – 105Combined sources6
Helixi107 – 117Combined sources11
Beta strandi122 – 128Combined sources7
Beta strandi130 – 132Combined sources3
Helixi135 – 152Combined sources18
Beta strandi158 – 167Combined sources10
Helixi169 – 171Combined sources3
Beta strandi174 – 177Combined sources4
Beta strandi184 – 193Combined sources10
Beta strandi199 – 207Combined sources9
Turni208 – 211Combined sources4
Helixi217 – 222Combined sources6
Beta strandi225 – 233Combined sources9
Helixi238 – 248Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WQKX-ray1.50A/B1-251[»]
ProteinModelPortaliO67004.
SMRiO67004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
InParanoidiO67004.
KOiK03787.
OMAiNLNIPPC.
OrthoDBiPOG091H01CP.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

O67004-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTFLLVNDD GYFSPGINAL REALKSLGRV VVVAPDRNLS GVGHSLTFTE
60 70 80 90 100
PLKMRKIDTD FYTVIDGTPA DCVHLGYRVI LEEKKPDLVL SGINEGPNLG
110 120 130 140 150
EDITYSGTVS GAMEGRILGI PSIAFSAFGR ENIMFEEIAK VCVDIVKKVL
160 170 180 190 200
NEGIPEDTYL NVNIPNLRYE EIKGIKVTRQ GKRAYKERVF KYIDPYGKPF
210 220 230 240 250
YWIAAEEFGW HAEEGTDYWA VLNGYVSVTP LHLDLTNYKV MKSIKYLEDS

P
Length:251
Mass (Da):28,165
Last modified:August 1, 1998 - v1
Checksum:i7D36DDD8BEB1C55B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06967.1.
PIRiA70372.
RefSeqiNP_213565.1. NC_000918.1.
WP_010880503.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06967; AAC06967; aq_832.
GeneIDi1193454.
KEGGiaae:aq_832.
PATRICi20959050. VBIAquAeo85532_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06967.1.
PIRiA70372.
RefSeqiNP_213565.1. NC_000918.1.
WP_010880503.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WQKX-ray1.50A/B1-251[»]
ProteinModelPortaliO67004.
SMRiO67004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06967; AAC06967; aq_832.
GeneIDi1193454.
KEGGiaae:aq_832.
PATRICi20959050. VBIAquAeo85532_0650.

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122501.
InParanoidiO67004.
KOiK03787.
OMAiNLNIPPC.
OrthoDBiPOG091H01CP.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiIPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
PfamiPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSURE_AQUAE
AccessioniPrimary (citable) accession number: O67004
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.