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O67004 (SURE_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5'-nucleotidase surE
EC=3.1.3.5
Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase
Gene names
Name:surE
Ordered Locus Names:aq_832
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060

Catalytic activity

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060

Cofactor

Binds 1 divalent metal cation per subunit By similarity.

Subcellular location

Cytoplasm Potential HAMAP MF_00060.

Sequence similarities

Belongs to the surE nucleotidase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function5'-nucleotidase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2512515'-nucleotidase surE HAMAP MF_00060
PRO_0000111788

Sites

Metal binding91Divalent metal cation By similarity
Metal binding101Divalent metal cation By similarity
Metal binding401Divalent metal cation By similarity
Metal binding941Divalent metal cation By similarity

Secondary structure

1 ........................................... 251
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O67004 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 7D36DDD8BEB1C55B

FASTA25128,165
        10         20         30         40         50         60 
MPTFLLVNDD GYFSPGINAL REALKSLGRV VVVAPDRNLS GVGHSLTFTE PLKMRKIDTD 

        70         80         90        100        110        120 
FYTVIDGTPA DCVHLGYRVI LEEKKPDLVL SGINEGPNLG EDITYSGTVS GAMEGRILGI 

       130        140        150        160        170        180 
PSIAFSAFGR ENIMFEEIAK VCVDIVKKVL NEGIPEDTYL NVNIPNLRYE EIKGIKVTRQ 

       190        200        210        220        230        240 
GKRAYKERVF KYIDPYGKPF YWIAAEEFGW HAEEGTDYWA VLNGYVSVTP LHLDLTNYKV 

       250 
MKSIKYLEDS P

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC06967.1.
PIRA70372.
RefSeqNP_213565.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2WQKX-ray1.50A/B1-251[»]
ProteinModelPortalO67004.
SMRO67004. Positions 2-249.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1193454.
GenomeReviewsGene locus aq_832 in contig AE000657_GR.
KEGGaae:aq_832.
NMPDRfig|224324.1.peg.580.
PATRIC20959050. VBIAquAeo85532_0650.

Phylogenomic databases

HOGENOMHBG600532.
OMANGFYYVN.
PhylomeDBO67004.
ProtClustDBPRK00346.

Enzyme and pathway databases

BioCycAAEO224324:AQ_832-MONOMER.

Family and domain databases

HAMAPMF_00060. SurE.
[Tree]
InterProIPR002828. SurE-like_Pase/nucleotidase.
[Graphical view]
Gene3DG3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KOK03787.
PfamPF01975. SurE. 1 hit.
[Graphical view]
SUPFAMSSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMsTIGR00087. SurE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSURE_AQUAE
AccessionPrimary (citable) accession number: O67004
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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