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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301NADBy similarity
Binding sitei187 – 1871NADBy similarity
Binding sitei210 – 2101NADBy similarity
Binding sitei233 – 2331SubstrateBy similarity
Metal bindingi255 – 2551ZincBy similarity
Binding sitei255 – 2551SubstrateBy similarity
Metal bindingi258 – 2581ZincBy similarity
Binding sitei258 – 2581SubstrateBy similarity
Active sitei323 – 3231Proton acceptorBy similarity
Active sitei324 – 3241Proton acceptorBy similarity
Binding sitei324 – 3241SubstrateBy similarity
Metal bindingi357 – 3571ZincBy similarity
Binding sitei357 – 3571SubstrateBy similarity
Binding sitei411 – 4111SubstrateBy similarity
Metal bindingi416 – 4161ZincBy similarity
Binding sitei416 – 4161SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-561-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:aq_782
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Histidinol dehydrogenasePRO_0000135717Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_782.

Structurei

3D structure databases

ProteinModelPortaliO66976.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiO66976.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66976-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIEDLRKED WKLNERLEYL AKRGEILEEE YEKSVKEILK RVREEGDRAV
60 70 80 90 100
IEFTKKFDGV ELTPENMEVP FEELEKAYEE IEPEVREALE FAENRIRVFH
110 120 130 140 150
EKQLENSFFK EEEGIILGQK VVPLEKVGVY VPGGKAAYPS TVLMNVVPAS
160 170 180 190 200
VAGVEEIIMV SPKPNKYTLA AAYIAGVSRV FQVGGAQAIG ALAYGTEKIP
210 220 230 240 250
KVDKIVGPGN IYVALAKKLV FGTVDIDMIA GPSEVLVIAD ERANPTWVAA
260 270 280 290 300
DMLSQAEHDE LAASILLTPS EELANKVKEE VERLLSQLER KEIAQKSLEK
310 320 330 340 350
FGTIFLVKDL YHACEVANYI APEHLEVMVR EPMALLPELK HAGAIFLGDY
360 370 380 390 400
TTEPLGDYVL GPNHTLPTGG STRFFSPLGV YDFIKRSSVL YVSREGFKRV
410 420
ANQAEAIAKA EGLTAHALAV KVRKND
Length:426
Mass (Da):47,447
Last modified:August 1, 1998 - v1
Checksum:i3F54ED61A772C005
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06931.1.
PIRiE70368.
RefSeqiNP_213537.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06931; AAC06931; aq_782.
GeneIDi1193426.
KEGGiaae:aq_782.
PATRICi20958980. VBIAquAeo85532_0621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06931.1.
PIRiE70368.
RefSeqiNP_213537.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66976.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_782.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06931; AAC06931; aq_782.
GeneIDi1193426.
KEGGiaae:aq_782.
PATRICi20958980. VBIAquAeo85532_0621.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiO66976.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciAAEO224324:GJBH-561-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiHISX_AQUAE
AccessioniPrimary (citable) accession number: O66976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.