Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O66976 (HISX_AQUAE)

Last modified June 16, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase
      Short name=HDH
    EC=1.1.1.23
Gene names
Name: hisD
Ordered Locus Names: aq_782
OrganismAquifex aeolicus [Complete proteome] [HAMAP]
Taxonomic identifier63363 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Hide | Top

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 426426Histidinol dehydrogenase HAMAP MF_01024
PRO_0000135717

Sites

Active site3231Proton acceptor By similarity
Active site3241Proton acceptor By similarity
Metal binding2551Zinc By similarity
Metal binding2581Zinc By similarity
Metal binding3571Zinc By similarity
Metal binding4161Zinc By similarity
Binding site1301NAD By similarity
Binding site1871NAD By similarity
Binding site2101NAD By similarity
Binding site2331Substrate By similarity
Binding site2551Substrate By similarity
Binding site2581Substrate By similarity
Binding site3241Substrate By similarity
Binding site3571Substrate By similarity
Binding site4111Substrate By similarity
Binding site4161Substrate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O66976-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 3F54ED61A772C005

FASTA42647,447
        10         20         30         40         50         60 
MRIEDLRKED WKLNERLEYL AKRGEILEEE YEKSVKEILK RVREEGDRAV IEFTKKFDGV 

        70         80         90        100        110        120 
ELTPENMEVP FEELEKAYEE IEPEVREALE FAENRIRVFH EKQLENSFFK EEEGIILGQK 

       130        140        150        160        170        180 
VVPLEKVGVY VPGGKAAYPS TVLMNVVPAS VAGVEEIIMV SPKPNKYTLA AAYIAGVSRV 

       190        200        210        220        230        240 
FQVGGAQAIG ALAYGTEKIP KVDKIVGPGN IYVALAKKLV FGTVDIDMIA GPSEVLVIAD 

       250        260        270        280        290        300 
ERANPTWVAA DMLSQAEHDE LAASILLTPS EELANKVKEE VERLLSQLER KEIAQKSLEK 

       310        320        330        340        350        360 
FGTIFLVKDL YHACEVANYI APEHLEVMVR EPMALLPELK HAGAIFLGDY TTEPLGDYVL 

       370        380        390        400        410        420 
GPNHTLPTGG STRFFSPLGV YDFIKRSSVL YVSREGFKRV ANQAEAIAKA EGLTAHALAV 


KVRKND

« Hide

Hide | Top

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Hide | Top

Cross-references

Sequence databases

AE000657 Genomic DNA. Translation: AAC06931.1.
PIRE70368.
RefSeqNP_213537.1.

3D structure databases

HSSPHSSP built from PDB template 1K75 based on UniProtKB P06988.
ModBaseSearch...

Genome annotation databases

GeneID1193426.
GenomeReviewsGene locus aq_782 in contig AE000657_GR.
KEGGaae:aq_782.
NMPDRfig|224324.1.peg.552.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO66976.
OMAO66976. LDAHKNA.

Enzyme and pathway databases

BioCycAAEO224324:AQ_782-MON.
BRENDA1.1.1.23. 189781.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH_prok-type.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameHISX_AQUAE
AccessionPrimary (citable) accession number: O66976
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 16, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents