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O66976

- HISX_AQUAE

UniProt

O66976 - HISX_AQUAE

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei130 – 1301NADBy similarity
    Binding sitei187 – 1871NADBy similarity
    Binding sitei210 – 2101NADBy similarity
    Binding sitei233 – 2331SubstrateBy similarity
    Metal bindingi255 – 2551ZincBy similarity
    Binding sitei255 – 2551SubstrateBy similarity
    Metal bindingi258 – 2581ZincBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Active sitei323 – 3231Proton acceptorBy similarity
    Active sitei324 – 3241Proton acceptorBy similarity
    Binding sitei324 – 3241SubstrateBy similarity
    Metal bindingi357 – 3571ZincBy similarity
    Binding sitei357 – 3571SubstrateBy similarity
    Binding sitei411 – 4111SubstrateBy similarity
    Metal bindingi416 – 4161ZincBy similarity
    Binding sitei416 – 4161SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-561-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    Ordered Locus Names:aq_782
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 426426Histidinol dehydrogenasePRO_0000135717Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_782.

    Structurei

    3D structure databases

    ProteinModelPortaliO66976.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O66976-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIEDLRKED WKLNERLEYL AKRGEILEEE YEKSVKEILK RVREEGDRAV    50
    IEFTKKFDGV ELTPENMEVP FEELEKAYEE IEPEVREALE FAENRIRVFH 100
    EKQLENSFFK EEEGIILGQK VVPLEKVGVY VPGGKAAYPS TVLMNVVPAS 150
    VAGVEEIIMV SPKPNKYTLA AAYIAGVSRV FQVGGAQAIG ALAYGTEKIP 200
    KVDKIVGPGN IYVALAKKLV FGTVDIDMIA GPSEVLVIAD ERANPTWVAA 250
    DMLSQAEHDE LAASILLTPS EELANKVKEE VERLLSQLER KEIAQKSLEK 300
    FGTIFLVKDL YHACEVANYI APEHLEVMVR EPMALLPELK HAGAIFLGDY 350
    TTEPLGDYVL GPNHTLPTGG STRFFSPLGV YDFIKRSSVL YVSREGFKRV 400
    ANQAEAIAKA EGLTAHALAV KVRKND 426
    Length:426
    Mass (Da):47,447
    Last modified:August 1, 1998 - v1
    Checksum:i3F54ED61A772C005
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06931.1.
    PIRiE70368.
    RefSeqiNP_213537.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC06931; AAC06931; aq_782.
    GeneIDi1193426.
    KEGGiaae:aq_782.
    PATRICi20958980. VBIAquAeo85532_0621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06931.1 .
    PIRi E70368.
    RefSeqi NP_213537.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O66976.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_782.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC06931 ; AAC06931 ; aq_782 .
    GeneIDi 1193426.
    KEGGi aae:aq_782.
    PATRICi 20958980. VBIAquAeo85532_0621.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci AAEO224324:GJBH-561-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiHISX_AQUAE
    AccessioniPrimary (citable) accession number: O66976
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3