Reviewed, UniProtKB/Swiss-Prot O66963 (SYK3_AQUAE)

Names and origin

Protein names

Recommended name:
    Putative lysyl-tRNA synthetase
    EC=6.1.1.6
Alternative name(s):
    Lysine--tRNA ligase
      Short name=LysRS
    GX

Gene names

Name:	poxA
Synonyms:	genX
Ordered Locus Names:	aq_763

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Could be a lysyl-tRNA synthetase. HAMAP MF_00174
Catalytic activity	ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). HAMAP MF_00174
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP lysine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Putative lysyl-tRNA synthetase HAMAP MF_00174		PRO_0000152715

Sequences

	Sequence		Length	Mass (Da)
	O66963-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: B8B38B08BDD0EB9B	FASTA	293	35,013
	10 20 30 40 50 60 MDLLDAWDYF INEVRKFFKE KGYTEVSTPL LLDFPNLDSN VEPVKVEVLE RGENKVKWLH 70 80 90 100 110 120 TSPEYSMKKL LSRYKRDIFQ ITKVFRNNEW GRLHRIEFHM LEWYAVGCDY LYLIEELKQL 130 140 150 160 170 180 LNKLFGFKEF EVITVEEAFK RHFGEGIPQE ESSMKELLER KGIDFSEDED WETLFYRAFI 190 200 210 220 230 240 EVERHLGFNR PTFLINFPER LCALAKVRNG YAERFELFIK GIELANGWTE ETNPEEVRKR 250 260 270 280 290 LEREAKKRNL PLDEDFIKAH EDMPECAGCS LGIDRLFSLF LGKEELVSEF FRA

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC06920.1.
PIR	H70366.
RefSeq	NP_213524.1.
3D structure databases
HSSP	HSSP built from PDB template 1BBW based on UniProtKB P13030.
ModBase	Search...
Genome annotation databases
GeneID	1193413.
GenomeReviews	Gene locus aq_763 in contig AE000657_GR.
KEGG	aae:aq_763.
NMPDR	fig|224324.1.peg.539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O66963.
OMA	TYPIDED.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_763-MON.
BRENDA	6.1.1.6. 189781.
Family and domain databases
HAMAP	MF_00174. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004525. Lys-tRNA-synth-rel. [Graphical view]
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR00462. genX. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYK3_AQUAE

Accession

Primary (citable) accession number: O66963

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 1, 1998
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)