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O66954

- PGMI_AQUAE

UniProt

O66954 - PGMI_AQUAE

Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

aq_750

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.
    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei204 – 2041Proton acceptorBy similarity
    Active sitei220 – 2201Proton donorBy similarity
    Active sitei313 – 3131Proton acceptorBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
    3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-539-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional phosphoglucose/phosphomannose isomerase
    Alternative name(s):
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Ordered Locus Names:aq_750
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227793Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi224324.aq_750.

    Structurei

    3D structure databases

    ProteinModelPortaliO66954.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 153134SISPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PGI/PMI family.Curated
    Contains 1 SIS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000020037.
    KOiK15916.
    OMAiIAERWKG.
    OrthoDBiEOG6RC3QN.

    Family and domain databases

    InterProiIPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF10432. bact-PGI_C. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O66954-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEVYKVVEG FYNQFEWEDI AKDLTPYKGI VFCGMGGSGI IGSFASKWLE    50
    HRSFNKPTFV VKDYTLPPFV DRDYLVFCIS YSGNTEETLS NFEEAIGRGI 100
    KPLCITSNGK LMERAKEEGC EIYEVPKGFQ PRYSLGFMLS KVLNLLGVDK 150
    DELEDAKENL KENLESLKQK GKEIANRIYG YIPVVYSTPL TAHIAERWKG 200
    QINENSKSPA YFTILPEMHH NEVMGWSNPE LRNKFVYLLM FDEKDHHRVK 250
    LRVDITKKIL EDFGVVPIML KGEGNSYLAR SLYLVHLADW VSVFLAELYG 300
    YDPVPVKTIE RIKEELKKHA 320
    Length:320
    Mass (Da):36,847
    Last modified:August 1, 1998 - v1
    Checksum:i732BD143902F5AC7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06906.1.
    PIRiG70365.
    RefSeqiNP_213515.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC06906; AAC06906; aq_750.
    GeneIDi1193404.
    KEGGiaae:aq_750.
    PATRICi20958934. VBIAquAeo85532_0598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06906.1 .
    PIRi G70365.
    RefSeqi NP_213515.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O66954.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_750.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC06906 ; AAC06906 ; aq_750 .
    GeneIDi 1193404.
    KEGGi aae:aq_750.
    PATRICi 20958934. VBIAquAeo85532_0598.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000020037.
    KOi K15916.
    OMAi IAERWKG.
    OrthoDBi EOG6RC3QN.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-539-MONOMER.

    Family and domain databases

    InterProi IPR011857. Glu6P/Mann6P_isomerase.
    IPR019490. Glu6P/Mann6P_isomerase_C.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF10432. bact-PGI_C. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiPGMI_AQUAE
    AccessioniPrimary (citable) accession number: O66954
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3