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O66954

- PGMI_AQUAE

UniProt

O66954 - PGMI_AQUAE

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Protein
Bifunctional phosphoglucose/phosphomannose isomerase
Gene
aq_750
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041Proton acceptor By similarity
Active sitei220 – 2201Proton donor By similarity
Active sitei313 – 3131Proton acceptor By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:aq_750
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227793Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi224324.aq_750.

Structurei

3D structure databases

ProteinModelPortaliO66954.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 153134SIS
Add
BLAST

Sequence similaritiesi

Belongs to the PGI/PMI family.
Contains 1 SIS domain.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000020037.
KOiK15916.
OMAiIAERWKG.
OrthoDBiEOG6RC3QN.

Family and domain databases

InterProiIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamiPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66954-1 [UniParc]FASTAAdd to Basket

« Hide

MEEVYKVVEG FYNQFEWEDI AKDLTPYKGI VFCGMGGSGI IGSFASKWLE    50
HRSFNKPTFV VKDYTLPPFV DRDYLVFCIS YSGNTEETLS NFEEAIGRGI 100
KPLCITSNGK LMERAKEEGC EIYEVPKGFQ PRYSLGFMLS KVLNLLGVDK 150
DELEDAKENL KENLESLKQK GKEIANRIYG YIPVVYSTPL TAHIAERWKG 200
QINENSKSPA YFTILPEMHH NEVMGWSNPE LRNKFVYLLM FDEKDHHRVK 250
LRVDITKKIL EDFGVVPIML KGEGNSYLAR SLYLVHLADW VSVFLAELYG 300
YDPVPVKTIE RIKEELKKHA 320
Length:320
Mass (Da):36,847
Last modified:August 1, 1998 - v1
Checksum:i732BD143902F5AC7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06906.1.
PIRiG70365.
RefSeqiNP_213515.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06906; AAC06906; aq_750.
GeneIDi1193404.
KEGGiaae:aq_750.
PATRICi20958934. VBIAquAeo85532_0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06906.1 .
PIRi G70365.
RefSeqi NP_213515.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06906 ; AAC06906 ; aq_750 .
GeneIDi 1193404.
KEGGi aae:aq_750.
PATRICi 20958934. VBIAquAeo85532_0598.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000020037.
KOi K15916.
OMAi IAERWKG.
OrthoDBi EOG6RC3QN.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-539-MONOMER.

Family and domain databases

InterProi IPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view ]
Pfami PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiPGMI_AQUAE
AccessioniPrimary (citable) accession number: O66954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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