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O66954 (PGMI_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphoglucose isomerase
Short name=PGI
Phosphomannose isomerase
Short name=PMI
Gene names
Ordered Locus Names:aq_750
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

D-mannose 6-phosphate = D-fructose 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PGI/PMI family.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227793

Regions

Domain20 – 153134SIS

Sites

Active site2041Proton acceptor By similarity
Active site2201Proton donor By similarity
Active site3131Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
O66954 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 732BD143902F5AC7

FASTA32036,847
        10         20         30         40         50         60 
MEEVYKVVEG FYNQFEWEDI AKDLTPYKGI VFCGMGGSGI IGSFASKWLE HRSFNKPTFV 

        70         80         90        100        110        120 
VKDYTLPPFV DRDYLVFCIS YSGNTEETLS NFEEAIGRGI KPLCITSNGK LMERAKEEGC 

       130        140        150        160        170        180 
EIYEVPKGFQ PRYSLGFMLS KVLNLLGVDK DELEDAKENL KENLESLKQK GKEIANRIYG 

       190        200        210        220        230        240 
YIPVVYSTPL TAHIAERWKG QINENSKSPA YFTILPEMHH NEVMGWSNPE LRNKFVYLLM 

       250        260        270        280        290        300 
FDEKDHHRVK LRVDITKKIL EDFGVVPIML KGEGNSYLAR SLYLVHLADW VSVFLAELYG 

       310        320 
YDPVPVKTIE RIKEELKKHA 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC06906.1.
PIRG70365.
RefSeqNP_213515.1. NC_000918.1.

3D structure databases

ProteinModelPortalO66954.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC06906; AAC06906; aq_750.
GeneID1193404.
KEGGaae:aq_750.
PATRIC20958934. VBIAquAeo85532_0598.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000020037.
KOK15916.
OMAPELNHNE.
OrthoDBEOG6RC3QN.
ProtClustDBPRK08674.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-539-MONOMER.

Family and domain databases

InterProIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR02128. G6PI_arch. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGMI_AQUAE
AccessionPrimary (citable) accession number: O66954
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 1, 1998
Last modified: November 13, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families