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O66954

- PGMI_AQUAE

UniProt

O66954 - PGMI_AQUAE

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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

aq_750

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei204 – 2041Proton acceptorBy similarity
Active sitei220 – 2201Proton donorBy similarity
Active sitei313 – 3131Proton acceptorBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glucose-6-phosphate isomerase activity Source: UniProtKB-EC
  3. mannose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:aq_750
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Bifunctional phosphoglucose/phosphomannose isomerasePRO_0000227793Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_750.

Structurei

3D structure databases

ProteinModelPortaliO66954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 153134SISPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated
Contains 1 SIS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000020037.
InParanoidiO66954.
KOiK15916.
OMAiIAERWKG.
OrthoDBiEOG6RC3QN.

Family and domain databases

InterProiIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamiPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiPS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66954-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEVYKVVEG FYNQFEWEDI AKDLTPYKGI VFCGMGGSGI IGSFASKWLE
60 70 80 90 100
HRSFNKPTFV VKDYTLPPFV DRDYLVFCIS YSGNTEETLS NFEEAIGRGI
110 120 130 140 150
KPLCITSNGK LMERAKEEGC EIYEVPKGFQ PRYSLGFMLS KVLNLLGVDK
160 170 180 190 200
DELEDAKENL KENLESLKQK GKEIANRIYG YIPVVYSTPL TAHIAERWKG
210 220 230 240 250
QINENSKSPA YFTILPEMHH NEVMGWSNPE LRNKFVYLLM FDEKDHHRVK
260 270 280 290 300
LRVDITKKIL EDFGVVPIML KGEGNSYLAR SLYLVHLADW VSVFLAELYG
310 320
YDPVPVKTIE RIKEELKKHA
Length:320
Mass (Da):36,847
Last modified:August 1, 1998 - v1
Checksum:i732BD143902F5AC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06906.1.
PIRiG70365.
RefSeqiNP_213515.1. NC_000918.1.
WP_010880453.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06906; AAC06906; aq_750.
GeneIDi1193404.
KEGGiaae:aq_750.
PATRICi20958934. VBIAquAeo85532_0598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06906.1 .
PIRi G70365.
RefSeqi NP_213515.1. NC_000918.1.
WP_010880453.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66954.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_750.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06906 ; AAC06906 ; aq_750 .
GeneIDi 1193404.
KEGGi aae:aq_750.
PATRICi 20958934. VBIAquAeo85532_0598.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000020037.
InParanoidi O66954.
KOi K15916.
OMAi IAERWKG.
OrthoDBi EOG6RC3QN.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-539-MONOMER.

Family and domain databases

InterProi IPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view ]
Pfami PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02128. G6PI_arch. 1 hit.
PROSITEi PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiPGMI_AQUAE
AccessioniPrimary (citable) accession number: O66954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 1, 1998
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3