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Reviewed, UniProtKB/Swiss-Prot O66954 (PGMI_AQUAE)

Last modified March 2, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
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Names and originHide

Protein namesRecommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Phosphoglucose isomerase
Short name=PGI
Mannose-6-phosphate isomerase
EC=5.3.1.8
Phosphomannose isomerase
Short name=PMI
Gene names
Ordered Locus Names:aq_750
OrganismAquifex aeolicus [Complete proteome] [HAMAP]
Taxonomic identifier63363 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex
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Protein attributesHide

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology.
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General annotation (Comments)Hide

Function

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency By similarity.

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate.

D-mannose 6-phosphate = D-fructose 6-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the PGI/PMI family.

Contains 1 SIS domain.

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Sequence annotation (Features)Hide

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Bifunctional phosphoglucose/phosphomannose isomerase
PRO_0000227793

Regions

Domain20 – 153134SIS

Sites

Active site2041Proton acceptor By similarity
Active site2201Proton donor By similarity
Active site3131Proton acceptor By similarity
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SequencesHide

Sequence LengthMass (Da)Tools
O66954-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 732BD143902F5AC7

FASTA32036,847
        10         20         30         40         50         60 
MEEVYKVVEG FYNQFEWEDI AKDLTPYKGI VFCGMGGSGI IGSFASKWLE HRSFNKPTFV 

        70         80         90        100        110        120 
VKDYTLPPFV DRDYLVFCIS YSGNTEETLS NFEEAIGRGI KPLCITSNGK LMERAKEEGC 

       130        140        150        160        170        180 
EIYEVPKGFQ PRYSLGFMLS KVLNLLGVDK DELEDAKENL KENLESLKQK GKEIANRIYG 

       190        200        210        220        230        240 
YIPVVYSTPL TAHIAERWKG QINENSKSPA YFTILPEMHH NEVMGWSNPE LRNKFVYLLM 

       250        260        270        280        290        300 
FDEKDHHRVK LRVDITKKIL EDFGVVPIML KGEGNSYLAR SLYLVHLADW VSVFLAELYG 

       310        320 
YDPVPVKTIE RIKEELKKHA 

« Hide

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ReferencesHide

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
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Cross-referencesHide

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC06906.1.
PIRG70365.
RefSeqNP_213515.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1193404.
GenomeReviewsGene locus aq_750 in contig AE000657_GR.
KEGGaae:aq_750.
NMPDRfig|224324.1.peg.530.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG507538.
OMAGNTEETL.
ProtClustDBPRK08674.

Enzyme and pathway databases

BioCycAAEO224324:AQ_750-MONOMER.
BRENDA5.3.1.8. 189781.
5.3.1.9. 189781.

Family and domain databases

InterProIPR011857. Glu6P/Mann6P_isomerase.
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR001347. SIS.
[Graphical view]
PfamPF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
TIGRFAMsTIGR02128. G6PI_arch. 1 hit.
PROSITEPS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...
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Entry informationHide

Entry namePGMI_AQUAE
AccessionPrimary (citable) accession number: O66954
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 1, 1998
Last modified: March 2, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
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Relevant documentsHide

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents