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Protein

Bifunctional phosphoglucose/phosphomannose isomerase

Gene

aq_750

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency.By similarity

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.
D-mannose 6-phosphate = D-fructose 6-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei204Proton acceptorBy similarity1
Active sitei220Proton donorBy similarity1
Active sitei313Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional phosphoglucose/phosphomannose isomerase
Alternative name(s):
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Phosphoglucose isomerase
Short name:
PGI
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Ordered Locus Names:aq_750
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277931 – 320Bifunctional phosphoglucose/phosphomannose isomeraseAdd BLAST320

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi224324.aq_750.

Structurei

3D structure databases

ProteinModelPortaliO66954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 153SISPROSITE-ProRule annotationAdd BLAST134

Sequence similaritiesi

Belongs to the PGI/PMI family.Curated

Phylogenomic databases

eggNOGiENOG4107VCH. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000020037.
InParanoidiO66954.
KOiK15916.
OMAiPELNHNE.
OrthoDBiPOG091H052Y.

Family and domain databases

CDDicd05017. SIS_PGI_PMI_1. 1 hit.
cd05637. SIS_PGI_PMI_2. 1 hit.
InterProiView protein in InterPro
IPR019490. Glu6P/Mann6P_isomerase_C.
IPR011857. PGI/PMI.
IPR001347. SIS.
IPR035484. SIS_PGI/PMI_1.
PfamiView protein in Pfam
PF10432. bact-PGI_C. 1 hit.
PF01380. SIS. 1 hit.
TIGRFAMsiTIGR02128. G6PI_arch. 1 hit.
PROSITEiView protein in PROSITE
PS51464. SIS. 1 hit.

Sequencei

Sequence statusi: Complete.

O66954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEVYKVVEG FYNQFEWEDI AKDLTPYKGI VFCGMGGSGI IGSFASKWLE
60 70 80 90 100
HRSFNKPTFV VKDYTLPPFV DRDYLVFCIS YSGNTEETLS NFEEAIGRGI
110 120 130 140 150
KPLCITSNGK LMERAKEEGC EIYEVPKGFQ PRYSLGFMLS KVLNLLGVDK
160 170 180 190 200
DELEDAKENL KENLESLKQK GKEIANRIYG YIPVVYSTPL TAHIAERWKG
210 220 230 240 250
QINENSKSPA YFTILPEMHH NEVMGWSNPE LRNKFVYLLM FDEKDHHRVK
260 270 280 290 300
LRVDITKKIL EDFGVVPIML KGEGNSYLAR SLYLVHLADW VSVFLAELYG
310 320
YDPVPVKTIE RIKEELKKHA
Length:320
Mass (Da):36,847
Last modified:August 1, 1998 - v1
Checksum:i732BD143902F5AC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06906.1.
PIRiG70365.
RefSeqiNP_213515.1. NC_000918.1.
WP_010880453.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06906; AAC06906; aq_750.
GeneIDi1193404.
KEGGiaae:aq_750.
PATRICifig|224324.8.peg.598.

Similar proteinsi

Entry informationi

Entry nameiPGMI_AQUAE
AccessioniPrimary (citable) accession number: O66954
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 1, 1998
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families