ID   ISPA_AQUAE              Reviewed;         262 AA.
AC   O66952;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Geranyltranstransferase;
DE            EC=2.5.1.10;
DE   AltName: Full=Farnesyl-diphosphate synthase;
DE            Short=FPP synthase;
GN   Name=ispA; OrderedLocusNames=aq_748;
OS   Aquifex aeolicus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=63363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + trans,trans-farnesyl diphosphate.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthetase family.
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DR   EMBL; AE000657; AAC06913.1; -; Genomic_DNA.
DR   PIR; E70365; E70365.
DR   RefSeq; NP_213513.1; -.
DR   GeneID; 1193402; -.
DR   GenomeReviews; AE000657_GR; aq_748.
DR   KEGG; aae:aq_748; -.
DR   NMPDR; fig|224324.1.peg.528; -.
DR   HOGENOM; O66952; -.
DR   OMA; O66952; HNYSLIH.
DR   BioCyc; AAEO224324:AQ_748-MON; -.
DR   BRENDA; 2.5.1.10; 189781.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:EC.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR017446; Polyprenyl_synth-rel.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   PANTHER; PTHR12001; Polyprenyl_synt; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHET_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHET_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Isoprene biosynthesis; Transferase.
FT   CHAIN         1    262       Geranyltranstransferase.
FT                                /FTId=PRO_0000123984.
SQ   SEQUENCE   262 AA;  30037 MW;  400592121D46C25E CRC64;
     MERIETWKEK IEKRLNEILK PEGPEELIEA MKYYPLQKGK RIRPLFTVAV ASALGGNEDD
     AITVGSGIEL IHNYSLIHDD LPCMDNDVWR RGLPTCHIKF GEAMALLAGD ALLTYTFEVL
     SQRENYKTLS CEEILEINKI IAQKAGSNGM VGGQVLDIKG YEDLYEVSVK KTGALFEACF
     MCGAVVAKRR EKLKEMESIG RKVGLLFQMV DDYLDKDGFY EKLGECLKEE IKKLYEELKE
     KEIFKESQEL RYLLDLIYKR IT
//