Reviewed, UniProtKB/Swiss-Prot O66952 (ISPA_AQUAE)

Names and origin

Protein names

Recommended name:
    Geranyltranstransferase
    EC=2.5.1.10
Alternative name(s):
    Farnesyl-diphosphate synthase
      Short name=FPP synthase

Gene names

Name:	ispA
Ordered Locus Names:	aq_748

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Geranyltranstransferase		PRO_0000123984

Sequences

	Sequence		Length	Mass (Da)
	O66952-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 400592121D46C25E	FASTA	262	30,037
	10 20 30 40 50 60 MERIETWKEK IEKRLNEILK PEGPEELIEA MKYYPLQKGK RIRPLFTVAV ASALGGNEDD 70 80 90 100 110 120 AITVGSGIEL IHNYSLIHDD LPCMDNDVWR RGLPTCHIKF GEAMALLAGD ALLTYTFEVL 130 140 150 160 170 180 SQRENYKTLS CEEILEINKI IAQKAGSNGM VGGQVLDIKG YEDLYEVSVK KTGALFEACF 190 200 210 220 230 240 MCGAVVAKRR EKLKEMESIG RKVGLLFQMV DDYLDKDGFY EKLGECLKEE IKKLYEELKE 250 260 KEIFKESQEL RYLLDLIYKR IT

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC06913.1.
PIR	E70365.
RefSeq	NP_213513.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1193402.
GenomeReviews	Gene locus aq_748 in contig AE000657_GR.
KEGG	aae:aq_748.
NMPDR	fig|224324.1.peg.528.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O66952.
OMA	O66952. HNYSLIH.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_748-MON.
BRENDA	2.5.1.10. 189781.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHER	PTHR12001. Polyprenyl_synt. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ISPA_AQUAE

Accession

Primary (citable) accession number: O66952

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)