Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot O66952 (ISPA_AQUAE)

Last modified November 3, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Geranyltranstransferase
    EC=2.5.1.10
Alternative name(s):
    Farnesyl-diphosphate synthase
      Short name=FPP synthase
Gene names
Name: ispA
Ordered Locus Names: aq_748
OrganismAquifex aeolicus [Complete proteome] [HAMAP]
Taxonomic identifier63363 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Hide | Top

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Catalytic activity

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the FPP/GGPP synthetase family.

Hide | Top

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiongeranyltranstransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Geranyltranstransferase
PRO_0000123984

Sites

Metal binding791Magnesium 1 By similarity
Metal binding791Magnesium 2 By similarity
Metal binding851Magnesium 1 By similarity
Metal binding851Magnesium 2 By similarity
Metal binding2111Magnesium 3 By similarity
Binding site401Isopentenyl diphosphate By similarity
Binding site431Isopentenyl diphosphate By similarity
Binding site721Isopentenyl diphosphate By similarity
Binding site901Geranyl diphosphate By similarity
Binding site911Isopentenyl diphosphate By similarity
Binding site1711Geranyl diphosphate By similarity
Binding site1721Geranyl diphosphate By similarity
Binding site2081Geranyl diphosphate By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
O66952-1 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 400592121D46C25E

FASTA26230,037
        10         20         30         40         50         60 
MERIETWKEK IEKRLNEILK PEGPEELIEA MKYYPLQKGK RIRPLFTVAV ASALGGNEDD 

        70         80         90        100        110        120 
AITVGSGIEL IHNYSLIHDD LPCMDNDVWR RGLPTCHIKF GEAMALLAGD ALLTYTFEVL 

       130        140        150        160        170        180 
SQRENYKTLS CEEILEINKI IAQKAGSNGM VGGQVLDIKG YEDLYEVSVK KTGALFEACF 

       190        200        210        220        230        240 
MCGAVVAKRR EKLKEMESIG RKVGLLFQMV DDYLDKDGFY EKLGECLKEE IKKLYEELKE 

       250        260 
KEIFKESQEL RYLLDLIYKR IT

« Hide

Hide | Top

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Hide | Top

Cross-references

Sequence databases

AE000657 Genomic DNA. Translation: AAC06913.1.
PIRE70365.
RefSeqNP_213513.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1193402.
GenomeReviewsGene locus aq_748 in contig AE000657_GR.
KEGGaae:aq_748.
NMPDRfig|224324.1.peg.528.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMO66952.
OMAHNYSLIH.

Enzyme and pathway databases

BioCycAAEO224324:AQ_748-MON.
BRENDA2.5.1.10. 189781.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
PROSITEPS00723. POLYPRENYL_SYNTHET_1. 1 hit.
PS00444. POLYPRENYL_SYNTHET_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameISPA_AQUAE
AccessionPrimary (citable) accession number: O66952
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents