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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-530-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:aq_736Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_736.

Structurei

3D structure databases

ProteinModelPortaliO66945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 322320FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini342 – 448107Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH4. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
InParanoidiO66945.
KOiK00382.
OMAiFIDPHHI.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFDLIIVGA GSGGYEAGLY AFRRGMKVAF VELSPETVGG NCLNRGCIPS
60 70 80 90 100
KYMRHGAYLL DKFQKMEQYG IISKGYDIEY KKLKEGRDNV VVTIRENFKK
110 120 130 140 150
FAQQLRIPIY YGKGVLKDPN TVFVEGPEET LKAKYILVAT GSSPTSVGNL
160 170 180 190 200
VPDGKYVIDT DQIWEIDYVP KKVLIVGGGA VGVEFAYIFR KYGSEVVLVE
210 220 230 240 250
IKDRLLPTPD IPEDSGRYLA RKLRELGVDI RTRTSVESWE KTQNGVKAKL
260 270 280 290 300
TDGSEVVADF ILLGVGRKPN TKGIGLEELG IEMDERGFVK TNEYAQTNIP
310 320 330 340 350
NIYACGDITS PLMLAHKSMY EGKIAVSHIL GERDWKKNER IIPKIIYSAL
360 370 380 390 400
EVASVGLTEE QAEDEDIEVR VGVASFVSNP KAMDDGENEG FVRIVADDET
410 420 430 440 450
GEILGCHIVG PHAGELIHQV VHMIKDGKTV EFASKTMYSH PSLSENIGIA
460
SSEVYYGPIS WVKRR
Length:465
Mass (Da):51,564
Last modified:August 1, 1998 - v1
Checksum:i7EC67DAF3C728B9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06905.1.
PIRiF70364.
RefSeqiNP_213506.1. NC_000918.1.
WP_010880444.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06905; AAC06905; aq_736.
GeneIDi1193395.
KEGGiaae:aq_736.
PATRICi20958916. VBIAquAeo85532_0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06905.1.
PIRiF70364.
RefSeqiNP_213506.1. NC_000918.1.
WP_010880444.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06905; AAC06905; aq_736.
GeneIDi1193395.
KEGGiaae:aq_736.
PATRICi20958916. VBIAquAeo85532_0589.

Phylogenomic databases

eggNOGiENOG4105CH4. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
InParanoidiO66945.
KOiK00382.
OMAiFIDPHHI.
OrthoDBiPOG091H0239.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-530-MONOMER.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO66945_AQUAE
AccessioniPrimary (citable) accession number: O66945
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.