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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-527-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdAImported
Ordered Locus Names:aq_736Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_736

Structurei

3D structure databases

ProteinModelPortaliO66945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 322FAD/NAD-binding_domInterPro annotationAdd BLAST320
Domaini342 – 448Pyr_redox_dimInterPro annotationAdd BLAST107

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH4 Bacteria
COG1249 LUCA
HOGENOMiHOG000276708
InParanoidiO66945
KOiK00382
OMAiRKANHYG
OrthoDBiPOG091H0239

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006258 Lipoamide_DH
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01350 lipoamide_DH, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

O66945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFDLIIVGA GSGGYEAGLY AFRRGMKVAF VELSPETVGG NCLNRGCIPS
60 70 80 90 100
KYMRHGAYLL DKFQKMEQYG IISKGYDIEY KKLKEGRDNV VVTIRENFKK
110 120 130 140 150
FAQQLRIPIY YGKGVLKDPN TVFVEGPEET LKAKYILVAT GSSPTSVGNL
160 170 180 190 200
VPDGKYVIDT DQIWEIDYVP KKVLIVGGGA VGVEFAYIFR KYGSEVVLVE
210 220 230 240 250
IKDRLLPTPD IPEDSGRYLA RKLRELGVDI RTRTSVESWE KTQNGVKAKL
260 270 280 290 300
TDGSEVVADF ILLGVGRKPN TKGIGLEELG IEMDERGFVK TNEYAQTNIP
310 320 330 340 350
NIYACGDITS PLMLAHKSMY EGKIAVSHIL GERDWKKNER IIPKIIYSAL
360 370 380 390 400
EVASVGLTEE QAEDEDIEVR VGVASFVSNP KAMDDGENEG FVRIVADDET
410 420 430 440 450
GEILGCHIVG PHAGELIHQV VHMIKDGKTV EFASKTMYSH PSLSENIGIA
460
SSEVYYGPIS WVKRR
Length:465
Mass (Da):51,564
Last modified:August 1, 1998 - v1
Checksum:i7EC67DAF3C728B9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06905.1
PIRiF70364
RefSeqiNP_213506.1, NC_000918.1
WP_010880444.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC06905; AAC06905; aq_736
GeneIDi1193395
KEGGiaae:aq_736

Similar proteinsi

Entry informationi

Entry nameiO66945_AQUAE
AccessioniPrimary (citable) accession number: O66945
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health