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Protein
Submitted name:

D-lactate dehydrogenase

Gene

ldhA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96LactateCombined sources1
Binding sitei171NADCombined sources1
Binding sitei203NADCombined sources1
Binding sitei231LactateCombined sources1
Binding sitei255NADCombined sources1
Binding sitei294LactateCombined sources1
Binding sitei297NAD; via amide nitrogenCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi151 – 152NADCombined sources2
Nucleotide bindingi229 – 231NADCombined sources3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

NADCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BRENDAi1.1.1.28. 396.

Names & Taxonomyi

Protein namesi
Submitted name:
D-lactate dehydrogenaseImported
Gene namesi
Name:ldhAImported
Ordered Locus Names:aq_727Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi169 ↔ 183Combined sources

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_727.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KB6X-ray2.12A/B/C/D1-334[»]
ProteinModelPortaliO66939.
SMRiO66939.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66939.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 3212-Hacid_dhInterPro annotationAdd BLAST319
Domaini106 – 2962-Hacid_dh_CInterPro annotationAdd BLAST191

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 74Lactate bindingCombined sources2

Sequence similaritiesi

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C5I. Bacteria.
COG1052. LUCA.
HOGENOMiHOG000136695.
InParanoidiO66939.
KOiK03778.
OMAiITPHIAY.
OrthoDBiPOG091H04R6.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLFTSVPQ EDVPFYQEAL KDLSLKIYTT DVSKVPENEL KKAELISVFV
60 70 80 90 100
YDKLTEELLS KMPRLKLIHT RSVGFDHIDL DYCKKKGILV THIPAYSPES
110 120 130 140 150
VAEHTFAMIL TLVKRLKRIE DRVKKLNFSQ DSEILARELN RLTLGVIGTG
160 170 180 190 200
RIGSRVAMYG LAFGMKVLCY DVVKREDLKE KGCVYTSLDE LLKESDVISL
210 220 230 240 250
HVPYTKETHH MINEERISLM KDGVYLINTA RGKVVDTDAL YRAYQRGKFS
260 270 280 290 300
GLGLDVFEDE EILILKKYTE GKATDKNLKI LELACKDNVI ITPHIAYYTD
310 320 330
KSLERIREET VKVVKAFVKG DLEQIKGNFV VGPS
Length:334
Mass (Da):38,071
Last modified:August 1, 1998 - v1
Checksum:i6D4C1C4789CB7B00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06898.1.
PIRiG70363.
RefSeqiNP_213499.1. NC_000918.1.
WP_010880437.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06898; AAC06898; aq_727.
GeneIDi1193388.
KEGGiaae:aq_727.
PATRICi20958902. VBIAquAeo85532_0582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06898.1.
PIRiG70363.
RefSeqiNP_213499.1. NC_000918.1.
WP_010880437.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KB6X-ray2.12A/B/C/D1-334[»]
ProteinModelPortaliO66939.
SMRiO66939.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06898; AAC06898; aq_727.
GeneIDi1193388.
KEGGiaae:aq_727.
PATRICi20958902. VBIAquAeo85532_0582.

Phylogenomic databases

eggNOGiENOG4105C5I. Bacteria.
COG1052. LUCA.
HOGENOMiHOG000136695.
InParanoidiO66939.
KOiK03778.
OMAiITPHIAY.
OrthoDBiPOG091H04R6.

Enzyme and pathway databases

BRENDAi1.1.1.28. 396.

Miscellaneous databases

EvolutionaryTraceiO66939.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR029752. D-isomer_DH_CS1.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO66939_AQUAE
AccessioniPrimary (citable) accession number: O66939
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.