Reviewed, UniProtKB/Swiss-Prot O66932 (PHSG_AQUAE)

Names and origin

Protein names

Recommended name:
    Glycogen phosphorylase
    EC=2.4.1.1

Gene names

Name:	glgP
Ordered Locus Names:	aq_717

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	692 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties By similarity.
Catalytic activity	(1,4-alpha-D-glucosyl)(n) + phosphate = (1,4-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
Cofactor	Pyridoxal phosphate By similarity.
Sequence similarities	Belongs to the glycogen phosphorylase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glycogen metabolism
Ligand	Pyridoxal phosphate
Molecular function	Glycosyltransferase Transferase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological process	glycogen metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphorylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 692	692	Glycogen phosphorylase		PRO_0000188548
Amino acid modifications
	Modified residue	586	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O66932-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 4DC0EA2B2E58BEA4	FASTA	692	81,158
	10 20 30 40 50 60 MEEEKVKEGL WELAYNLWWT WNPPAKELFR SIDPLLWKET KENPIELLRK TKLLENKLKD 70 80 90 100 110 120 EDFISHFKYV YSLYKTYMNR HSKYEDTYKK PIVFLSPEYG LHHTLLIYAG GLGFLAGDIL 130 140 150 160 170 180 KESSDLGFPL IGVGFMYPQG YVKQRIRVDG WQEDLDAQNQ KELMPVKKVL DKEGKWLKCY 190 200 210 220 230 240 VYVRDEKVYF GVWEVNVGKT KLYLLDTNVE ENTPWNREIS SRLYVPDKDL RLRQQIVLGF 250 260 270 280 290 300 GTVILLEKLG IDAGGFHINE DYPSFVFLAE IFKLLKKGLT WDKAIEEVRK ISLFTTHTPL 310 320 330 340 350 360 RVAVNTYPFH MIEEQFLFVK DVYGIDVKKV LELGTNPEDP SEGFNSTIMS LRLAKYVNAV 370 380 390 400 410 420 SKRHQEVSSK MWSFLFKEKE NPIDYVTNGV HFPTWICSDL RRLYEEYLGE NFVELHDHKS 430 440 450 460 470 480 LWELIRDIPD EELWEYHIRN KERLIEHIKD RARERWVKEK ADPSILMAEG LFLDSDVLTV 490 500 510 520 530 540 GFARRMTGYK RPDLIFTDVE RLKKIVNDSE RPVQIIFAGK AHPADIEGKK IIQRIFNFAK 550 560 570 580 590 600 DPEFGGRIAF VEDYDELLAH YMVRGVDVWL NNPLPPLEAC GTSGMKASMN GVLHLSILDG 610 620 630 640 650 660 WWIEGYNGKN GWAFGDYEVE GDRNRADAEA IYNILENEVI PLYYERDERG VPVKWISMMK 670 680 690 EAIKSITPNF CSRRMLKDYI NKFYSKILKE EG

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06896.1.
PIR	H70362.
RefSeq	NP_213492.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT35. Glycosyltransferase Family 35.
Genome annotation databases
GeneID	1193381.
GenomeReviews	Gene locus aq_717 in contig AE000657_GR.
KEGG	aae:aq_717.
NMPDR	fig|224324.1.peg.507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG302557.
OMA	ISGVDIW.
PhylomeDB	O66932.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_717-MONOMER.
BRENDA	2.4.1.1. 189781.
Family and domain databases
InterPro	IPR011834. Agluc_phsphrylas. IPR000811. Glyco_trans_35. [Graphical view]
PANTHER	PTHR11468. Glyco_trans_35. 1 hit.
Pfam	PF00343. Phosphorylase. 1 hit. [Graphical view]
PIRSF	PIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMs	TIGR02094. more_P_ylases. 1 hit.
PROSITE	PS00102. PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHSG_AQUAE

Accession

Primary (citable) accession number: O66932

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)