Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan synthase beta chain 1

Gene

trpB1

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-504-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain 1 (EC:4.2.1.20)
Gene namesi
Name:trpB1
Ordered Locus Names:aq_706
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000989121 – 397Tryptophan synthase beta chain 1Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi224324.aq_706

Structurei

3D structure databases

ProteinModelPortaliO66923
SMRiO66923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiENOG4105CG0 Bacteria
COG0133 LUCA
HOGENOMiHOG000161710
InParanoidiO66923
KOiK01696
OMAiHGMKSYF
OrthoDBiPOG091H02JY

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR42882 PTHR42882, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00263 trpB, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

O66923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNYPDERGY FGPFGGKFVP ETLMYALEEL EEKYRELKSD PEFQKELDYY
60 70 80 90 100
LREYAGRPTP LYFAEKLTKY VGGAKIYLKR EDLLHTGAHK INNTIGQCLL
110 120 130 140 150
TKRMGKKRVI AETGAGQHGV ATATASALFG LECVVYMGEE DAERQALNVF
160 170 180 190 200
RMKLLGAKVE IVKSGSRTLK DAINEALRDW VTNVESTHYV IGSVVGPHPF
210 220 230 240 250
PMIVRDFQSV IGRETKEQIL QKEGRLPDAI VACVGGGSNA MGIFYPFVED
260 270 280 290 300
KGVQLIGVEA GGYGLETGQH AASICGGSVG ILHGMKSYFL QDEEGQIQPT
310 320 330 340 350
HSISAGLDYP GVGPEHALFH EIKRAKYTTA TDEEALEGFK LLARTEGIIP
360 370 380 390
ALESAHAVIK AVEVARELGK DGIVVINLSG RGDKDMAHVM KHLSLEG
Length:397
Mass (Da):43,543
Last modified:August 1, 1998 - v1
Checksum:i3302F177E0E1B0E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06880.1
PIRiG70361
RefSeqiNP_213483.1, NC_000918.1
WP_010880421.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC06880; AAC06880; aq_706
GeneIDi1193372
KEGGiaae:aq_706
PATRICifig|224324.8.peg.565

Similar proteinsi

Entry informationi

Entry nameiTRPB1_AQUAE
AccessioniPrimary (citable) accession number: O66923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health