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Protein

Tryptophan synthase beta chain 1

Gene

trpB1

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.By similarity

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.

Cofactori

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain 1 (trpB1), Tryptophan synthase beta chain 2 (trpB2)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-507-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain 1 (EC:4.2.1.20)
Gene namesi
Name:trpB1
Ordered Locus Names:aq_706
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Tryptophan synthase beta chain 1PRO_0000098912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei90 – 901N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.By similarity

Protein-protein interaction databases

STRINGi224324.aq_706.

Structurei

3D structure databases

ProteinModelPortaliO66923.
SMRiO66923. Positions 10-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.Curated

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
InParanoidiO66923.
KOiK01696.
OMAiCQKEGII.
OrthoDBiPOG091H02JY.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNYPDERGY FGPFGGKFVP ETLMYALEEL EEKYRELKSD PEFQKELDYY
60 70 80 90 100
LREYAGRPTP LYFAEKLTKY VGGAKIYLKR EDLLHTGAHK INNTIGQCLL
110 120 130 140 150
TKRMGKKRVI AETGAGQHGV ATATASALFG LECVVYMGEE DAERQALNVF
160 170 180 190 200
RMKLLGAKVE IVKSGSRTLK DAINEALRDW VTNVESTHYV IGSVVGPHPF
210 220 230 240 250
PMIVRDFQSV IGRETKEQIL QKEGRLPDAI VACVGGGSNA MGIFYPFVED
260 270 280 290 300
KGVQLIGVEA GGYGLETGQH AASICGGSVG ILHGMKSYFL QDEEGQIQPT
310 320 330 340 350
HSISAGLDYP GVGPEHALFH EIKRAKYTTA TDEEALEGFK LLARTEGIIP
360 370 380 390
ALESAHAVIK AVEVARELGK DGIVVINLSG RGDKDMAHVM KHLSLEG
Length:397
Mass (Da):43,543
Last modified:August 1, 1998 - v1
Checksum:i3302F177E0E1B0E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06880.1.
PIRiG70361.
RefSeqiNP_213483.1. NC_000918.1.
WP_010880421.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06880; AAC06880; aq_706.
GeneIDi1193372.
KEGGiaae:aq_706.
PATRICi20958868. VBIAquAeo85532_0565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06880.1.
PIRiG70361.
RefSeqiNP_213483.1. NC_000918.1.
WP_010880421.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66923.
SMRiO66923. Positions 10-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_706.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06880; AAC06880; aq_706.
GeneIDi1193372.
KEGGiaae:aq_706.
PATRICi20958868. VBIAquAeo85532_0565.

Phylogenomic databases

eggNOGiENOG4105CG0. Bacteria.
COG0133. LUCA.
HOGENOMiHOG000161710.
InParanoidiO66923.
KOiK01696.
OMAiCQKEGII.
OrthoDBiPOG091H02JY.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.
BioCyciAAEO224324:GJBH-507-MONOMER.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPB1_AQUAE
AccessioniPrimary (citable) accession number: O66923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.