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O66914 (KDSB_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase
Gene names
Name:kdsB
Ordered Locus Names:aq_692
OrganismAquifex aeolicus (strain VF5)
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057

Catalytic activity

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057

Pathway

Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057

Subcellular location

Cytoplasm Potential HAMAP MF_00057.

Sequence similarities

Belongs to the KdsB family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Cellular componentCytoplasm
   Molecular functionNucleotidyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-deoxy-manno-octulosonate cytidylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2342343-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057
PRO_0000188496

Secondary structure

1 ........................................ 234
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O66914 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: C838A2B7B84437C1

FASTA23427,173
        10         20         30         40         50         60 
MRRAVIIPAR LGSTRLKEKP LKNLLGKPLI RWVVEGLVKT GERVILATDS ERVKEVVEDL 

        70         80         90        100        110        120 
CEVFLTPSDL PSGSDRVLYV VRDLDVDLII NYQGDEPFVY EEDIKLIFRE LEKGERVVTL 

       130        140        150        160        170        180 
ARKDKEAYER PEDVKVVLDR EGYALYFSRS PIPYFRKNDT FYPLKHVGIY GFRKETLMEF 

       190        200        210        220        230 
GAMPPSKLEQ IEGLEQLRLL ENGIKIKVLI TENYYHGVDT EEDLKIVEEK LKNL

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed: 9537320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC06870.1.
PIRF70360.
RefSeqNP_213474.1. NC_000918.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y6PX-ray2.10A/B/C1-234[»]
ProteinModelPortalO66914.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1193976.
GenomeReviewsGene locus aq_692 in contig AE000657_GR.
KEGGaae:aq_692.
NMPDRfig|224324.1.peg.489.
PATRIC20958850. VBIAquAeo85532_0556.

Phylogenomic databases

HOGENOMHBG637773.
OMAINVQADE.
PhylomeDBO66914.
ProtClustDBPRK05450.

Enzyme and pathway databases

BioCycAAEO224324:AQ_692-MONOMER.

Family and domain databases

HAMAPMF_00057. CMP-KDO_synth.
[Tree]
InterProIPR003329. Cytidylyl_trans.
IPR004528. KdsB.
[Graphical view]
KOK00979.
PfamPF02348. CTP_transf_3. 1 hit.
[Graphical view]
TIGRFAMsTIGR00466. KdsB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDSB_AQUAE
AccessionPrimary (citable) accession number: O66914
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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