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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146FADUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-497-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Synonyms:gid, gidA2
Ordered Locus Names:aq_691
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOPRO_0000117227Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_691.

Structurei

3D structure databases

ProteinModelPortaliO66913.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
InParanoidiO66913.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiPOG091H00B3.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEKVIVIGG GLAGSEAAWR LANEGHRVIL YEMRPKKMTP AHKTGNLAEL
60 70 80 90 100
VCSNTLGGLE LTTGAGLLKA EMQKLGSLVI EAAKVARVPA GGALGVDRKI
110 120 130 140 150
FSEYITEKIE SHPNITLIRE EVKEIPEDEV VVIATGPLTS DALSEKIKEL
160 170 180 190 200
VGYDTLYFYD AIAPIVEAES VDFSKGFWGS RYGKGGDDYF NCVLTEEEYK
210 220 230 240 250
KFYEELLKAE KVKPKDFEKA VHFEGCLPIE EMAERGYKTL LFGPMKPVGL
260 270 280 290 300
VDPRTGKEPF AVVQLRKENK EGTLLSLVGF QTKLTYKEQK RVFRLIPCLR
310 320 330 340 350
NAVFVRLGSM HRNTFIQSNK VLTHYLNLKK KENIFFAGQI TGVEGYVASS
360 370 380 390 400
ATGILAGINA GRLARGEKPL KAPTETMLGA LVNYIVTKEG ELQPMNPVFG
410 420 430 440
LLPPLEKKVR DKKKRKELMA KRALETMEKW IKENNLVPEG LVKVC
Length:445
Mass (Da):49,466
Last modified:August 1, 1998 - v1
Checksum:i0DD6C173FA37468D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06872.1.
PIRiE70360.
RefSeqiNP_213473.1. NC_000918.1.
WP_010880411.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06872; AAC06872; aq_691.
GeneIDi1193975.
KEGGiaae:aq_691.
PATRICi20958848. VBIAquAeo85532_0555.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06872.1.
PIRiE70360.
RefSeqiNP_213473.1. NC_000918.1.
WP_010880411.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66913.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_691.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06872; AAC06872; aq_691.
GeneIDi1193975.
KEGGiaae:aq_691.
PATRICi20958848. VBIAquAeo85532_0555.

Phylogenomic databases

eggNOGiENOG4107QXI. Bacteria.
COG1206. LUCA.
HOGENOMiHOG000252054.
InParanoidiO66913.
KOiK04094.
OMAiDYLNCPM.
OrthoDBiPOG091H00B3.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-497-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_01037. TrmFO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR002218. MnmG-rel.
IPR020595. MnmG-rel_CS.
IPR004417. TrmFO.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.
PROSITEiPS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRMFO_AQUAE
AccessioniPrimary (citable) accession number: O66913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.