Skip Header

Contribute Send feedback
Read comments (?) or add your own

O66849 (TRPE_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anthranilate synthase component 1
EC=4.1.3.27
Alternative name(s):
Anthranilate synthase component I
Gene names
Name:trpE
Ordered Locus Names:aq_582
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteria › Aquificae › Aquificales › Aquificaceae › Aquifex ›

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Anthranilate synthase component 1
PRO_0000154074

Sequences

Sequence LengthMass (Da)Tools
O66849 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: AC20BBB260867CEC

FASTA49457,087
        10         20         30         40         50         60 
MNLNLSLEEV RKLSENYNVI PLYTELLVDT ETPLSIFLKL KEKGQFNILL ESAEGGEKWG 

        70         80         90        100        110        120 
RYSFIITGSS FYLRTRKDIG EIYERGKVNF FETKDPLSKI KEVVKKFIPY HDERLPRFWG 

       130        140        150        160        170        180 
GLVGYFAYDV VKFYEPVEDK NPDPIHTYDI YLVLTDVVVI HDNLTGKIKV VVPIFAQNGI 

       190        200        210        220        230        240 
EEEYERAKNL IRDTVKKLKE RGTTFLNVVE KEPDFKNWRS NFTKEEFEDI VKKAKEYIAQ 

       250        260        270        280        290        300 
GDVIQVVLSQ RFRKRFKGNP DNIYRVLRFL NPSPYMYYLD FDQLKVIGSS PEILVRLEEG 

       310        320        330        340        350        360 
RIETRPIAGT RKRGRTEEED KRLEEDLLSD EKERAEHLML VDLARNDIGR VAKTGSVRVE 

       370        380        390        400        410        420 
NFMRIERYSH VMHIVSDVVG ELREGYDALD VLKATFPAGT VSGAPKVRAM QIIEELENER 

       430        440        450        460        470        480 
RGIYAGSVGY ISFQGNMDMA IAIRTAVYRD RDIFVQAGAG IVADSVPEKE WEETVNKAKA 

       490 
LMKAIEIAEE SQEE

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000657 Genomic DNA. Translation: AAC06796.1.
PIRE70352.
RefSeqNP_213409.1. NC_000918.1.

3D structure databases

ProteinModelPortalO66849.
ModBaseSearch...

Protein-protein interaction databases

STRING224324.aq_582.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC06796; AAC06796; aq_582.
GeneID1193267.
KEGGaae:aq_582.
PATRIC20958684. VBIAquAeo85532_0476.

Phylogenomic databases

eggNOGCOG0147.
HOGENOMHOG000025142.
KOK01657.
OMASHVVHIV.
ProtClustDBCLSK2299440.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-430-MONOMER.
UniPathwayUPA00035; UER00040.

Family and domain databases

Gene3D3.60.120.10. 1 hit.
InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR005256. Anth_synth_I_PabB.
IPR015890. Chorismate-bd_C.
[Graphical view]
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMsTIGR00564. trpE_most. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_AQUAE
AccessionPrimary (citable) accession number: O66849
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents