ID   O66844_AQUAE            Unreviewed;       271 AA.
AC   O66844;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   27-MAR-2024, entry version 137.
DE   SubName: Full=Ser/thr protein kinase {ECO:0000313|EMBL:AAC06804.1};
GN   Name=stpK {ECO:0000313|EMBL:AAC06804.1};
GN   OrderedLocusNames=aq_576 {ECO:0000313|EMBL:AAC06804.1};
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324 {ECO:0000313|EMBL:AAC06804.1, ECO:0000313|Proteomes:UP000000798};
RN   [1] {ECO:0000313|EMBL:AAC06804.1, ECO:0000313|Proteomes:UP000000798}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5 {ECO:0000313|EMBL:AAC06804.1,
RC   ECO:0000313|Proteomes:UP000000798};
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olson G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
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DR   EMBL; AE000657; AAC06804.1; -; Genomic_DNA.
DR   PIR; H70351; H70351.
DR   RefSeq; NP_213404.1; NC_000918.1.
DR   RefSeq; WP_010880342.1; NC_000918.1.
DR   AlphaFoldDB; O66844; -.
DR   STRING; 224324.aq_576; -.
DR   EnsemblBacteria; AAC06804; AAC06804; aq_576.
DR   KEGG; aae:aq_576; -.
DR   eggNOG; COG0515; Bacteria.
DR   HOGENOM; CLU_000288_63_0_0; -.
DR   InParanoid; O66844; -.
DR   OrthoDB; 1766482at2; -.
DR   BRENDA; 2.7.11.1; 396.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR   PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Kinase {ECO:0000313|EMBL:AAC06804.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000798};
KW   Transferase {ECO:0000313|EMBL:AAC06804.1}.
FT   DOMAIN          14..266
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         46
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   271 AA;  31532 MW;  207D4306FC2E987E CRC64;
     MEDFKSGDLI LGYYKVLEKL GEGNFGKVYK VEALKGRYKG KVFALKVASN PYSVHYLWKE
     AQTLILFHHQ NIVSLQSYLY KKDKKELYLI YEYMDFGTLK DYVEKKGKLS PEEALKVLRH
     VVNALEYLHS RGYIHSDLKP ENVFGKRVLG GVLWKLGDFS LVRIRGDVSI IDVKGTIGFI
     APEIFRGEIH RSSDIYSLGC LTLYMLTGKV PFEGKDFKER KEKNKRGEVE IPEEIPGKLK
     DLLERMLEVD YKRRFRTARE LKEYMVKEGL I
//