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O66821

- HPRT_AQUAE

UniProt

O66821 - HPRT_AQUAE

Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei106 – 1061Proton acceptorBy similarity
    Binding sitei134 – 1341IMPBy similarity
    Metal bindingi162 – 1621MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi102 – 11110IMPBy similarity
    Nucleotide bindingi161 – 1622IMPBy similarity

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: RefGenome
    3. magnesium ion binding Source: RefGenome
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. adenine salvage Source: RefGenome
    2. GMP salvage Source: RefGenome
    3. guanine salvage Source: RefGenome
    4. hypoxanthine metabolic process Source: RefGenome
    5. IMP salvage Source: RefGenome
    6. purine ribonucleoside salvage Source: RefGenome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-401-MONOMER.
    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
    Short name:
    HGPRT
    Short name:
    HGPRTase
    Gene namesi
    Name:hpt
    Ordered Locus Names:aq_544
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 178178Hypoxanthine-guanine phosphoribosyltransferasePRO_0000139601Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_544.

    Structurei

    3D structure databases

    ProteinModelPortaliO66821.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0634.
    HOGENOMiHOG000236520.
    KOiK00760.
    OMAiVDFMTVS.
    OrthoDBiEOG693GNP.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    InterProiIPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O66821-1 [UniParc]FASTAAdd to Basket

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    MKEIRGKKLK LLLKEEDIKR RVKELAKEIE SSYSWEEPIV VVGLLKGAFI    50
    FLADLVRAFD RFVFVEFMQV SSYGKGMKSS GTIKIVKDLD MDIEGKEVLL 100
    VDDILDTGLT MKEIHDYLLM KKPKVLKTCV FLDKKERRKV DFNADFVGFE 150
    VPDKFLVGYG LDWGEYGRNL PEVYMVED 178
    Length:178
    Mass (Da):20,628
    Last modified:August 1, 1998 - v1
    Checksum:iCBBA89459F690538
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06788.1.
    PIRiA70349.
    RefSeqiNP_213381.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC06788; AAC06788; aq_544.
    GeneIDi1193239.
    KEGGiaae:aq_544.
    PATRICi20958622. VBIAquAeo85532_0446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06788.1 .
    PIRi A70349.
    RefSeqi NP_213381.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O66821.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC06788 ; AAC06788 ; aq_544 .
    GeneIDi 1193239.
    KEGGi aae:aq_544.
    PATRICi 20958622. VBIAquAeo85532_0446.

    Phylogenomic databases

    eggNOGi COG0634.
    HOGENOMi HOG000236520.
    KOi K00760.
    OMAi VDFMTVS.
    OrthoDBi EOG693GNP.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .
    BioCyci AAEO224324:GJBH-401-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    InterProi IPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiHPRT_AQUAE
    AccessioniPrimary (citable) accession number: O66821
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3