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O66821

- HPRT_AQUAE

UniProt

O66821 - HPRT_AQUAE

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Protein
Hypoxanthine-guanine phosphoribosyltransferase
Gene
hpt, aq_544
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton acceptor By similarity
Binding sitei134 – 1341IMP By similarity
Metal bindingi162 – 1621Magnesium By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 11110IMP By similarity
Nucleotide bindingi161 – 1622IMP By similarity

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: RefGenome
  3. magnesium ion binding Source: RefGenome
  4. nucleotide binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. GMP salvage Source: RefGenome
  2. IMP salvage Source: RefGenome
  3. adenine salvage Source: RefGenome
  4. guanine salvage Source: RefGenome
  5. hypoxanthine metabolic process Source: RefGenome
  6. purine ribonucleoside salvage Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-401-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRT
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:aq_544
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139601Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_544.

Structurei

3D structure databases

ProteinModelPortaliO66821.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0634.
HOGENOMiHOG000236520.
KOiK00760.
OMAiVDFMTVS.
OrthoDBiEOG693GNP.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66821-1 [UniParc]FASTAAdd to Basket

« Hide

MKEIRGKKLK LLLKEEDIKR RVKELAKEIE SSYSWEEPIV VVGLLKGAFI    50
FLADLVRAFD RFVFVEFMQV SSYGKGMKSS GTIKIVKDLD MDIEGKEVLL 100
VDDILDTGLT MKEIHDYLLM KKPKVLKTCV FLDKKERRKV DFNADFVGFE 150
VPDKFLVGYG LDWGEYGRNL PEVYMVED 178
Length:178
Mass (Da):20,628
Last modified:August 1, 1998 - v1
Checksum:iCBBA89459F690538
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06788.1.
PIRiA70349.
RefSeqiNP_213381.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06788; AAC06788; aq_544.
GeneIDi1193239.
KEGGiaae:aq_544.
PATRICi20958622. VBIAquAeo85532_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06788.1 .
PIRi A70349.
RefSeqi NP_213381.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66821.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224324.aq_544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06788 ; AAC06788 ; aq_544 .
GeneIDi 1193239.
KEGGi aae:aq_544.
PATRICi 20958622. VBIAquAeo85532_0446.

Phylogenomic databases

eggNOGi COG0634.
HOGENOMi HOG000236520.
KOi K00760.
OMAi VDFMTVS.
OrthoDBi EOG693GNP.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci AAEO224324:GJBH-401-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiHPRT_AQUAE
AccessioniPrimary (citable) accession number: O66821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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