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O66821

- HPRT_AQUAE

UniProt

O66821 - HPRT_AQUAE

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Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactori

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei106 – 1061Proton acceptorBy similarity
Binding sitei134 – 1341IMPBy similarity
Metal bindingi162 – 1621MagnesiumBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi102 – 11110IMPBy similarity
Nucleotide bindingi161 – 1622IMPBy similarity

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: RefGenome
  3. magnesium ion binding Source: RefGenome
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. adenine salvage Source: RefGenome
  2. GMP salvage Source: RefGenome
  3. guanine salvage Source: RefGenome
  4. hypoxanthine metabolic process Source: RefGenome
  5. IMP salvage Source: RefGenome
  6. purine ribonucleoside salvage Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-401-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRT
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:aq_544
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Hypoxanthine-guanine phosphoribosyltransferasePRO_0000139601Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_544.

Structurei

3D structure databases

ProteinModelPortaliO66821.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0634.
HOGENOMiHOG000236520.
InParanoidiO66821.
KOiK00760.
OMAiVDFMTVS.
OrthoDBiEOG693GNP.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
InterProiIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66821-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEIRGKKLK LLLKEEDIKR RVKELAKEIE SSYSWEEPIV VVGLLKGAFI
60 70 80 90 100
FLADLVRAFD RFVFVEFMQV SSYGKGMKSS GTIKIVKDLD MDIEGKEVLL
110 120 130 140 150
VDDILDTGLT MKEIHDYLLM KKPKVLKTCV FLDKKERRKV DFNADFVGFE
160 170
VPDKFLVGYG LDWGEYGRNL PEVYMVED
Length:178
Mass (Da):20,628
Last modified:August 1, 1998 - v1
Checksum:iCBBA89459F690538
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06788.1.
PIRiA70349.
RefSeqiNP_213381.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06788; AAC06788; aq_544.
GeneIDi1193239.
KEGGiaae:aq_544.
PATRICi20958622. VBIAquAeo85532_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06788.1 .
PIRi A70349.
RefSeqi NP_213381.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66821.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06788 ; AAC06788 ; aq_544 .
GeneIDi 1193239.
KEGGi aae:aq_544.
PATRICi 20958622. VBIAquAeo85532_0446.

Phylogenomic databases

eggNOGi COG0634.
HOGENOMi HOG000236520.
InParanoidi O66821.
KOi K00760.
OMAi VDFMTVS.
OrthoDBi EOG693GNP.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci AAEO224324:GJBH-401-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
InterProi IPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiHPRT_AQUAE
AccessioniPrimary (citable) accession number: O66821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3