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O66821 (HPRT_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine-guanine phosphoribosyltransferase

Short name=HGPRT
Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:aq_544
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 178178Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139601

Regions

Nucleotide binding102 – 11110IMP By similarity
Nucleotide binding161 – 1622IMP By similarity

Sites

Active site1061Proton acceptor By similarity
Metal binding1621Magnesium By similarity
Binding site1341IMP By similarity

Sequences

Sequence LengthMass (Da)Tools
O66821 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: CBBA89459F690538

FASTA17820,628
        10         20         30         40         50         60 
MKEIRGKKLK LLLKEEDIKR RVKELAKEIE SSYSWEEPIV VVGLLKGAFI FLADLVRAFD 

        70         80         90        100        110        120 
RFVFVEFMQV SSYGKGMKSS GTIKIVKDLD MDIEGKEVLL VDDILDTGLT MKEIHDYLLM 

       130        140        150        160        170 
KKPKVLKTCV FLDKKERRKV DFNADFVGFE VPDKFLVGYG LDWGEYGRNL PEVYMVED 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC06788.1.
PIRA70349.
RefSeqNP_213381.1. NC_000918.1.

3D structure databases

ProteinModelPortalO66821.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_544.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC06788; AAC06788; aq_544.
GeneID1193239.
KEGGaae:aq_544.
PATRIC20958622. VBIAquAeo85532_0446.

Phylogenomic databases

eggNOGCOG0634.
HOGENOMHOG000236520.
KOK00760.
OMAVDFMTVS.
OrthoDBEOG693GNP.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-401-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_AQUAE
AccessionPrimary (citable) accession number: O66821
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways