O66820 (APGM_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	aq_542

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_B
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_B
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_B
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_B		PRO_0000138152

Sequences

	Sequence		Length	Mass (Da)
	O66820 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 263C18ACED69C33F	FASTA	407	45,006
	10 20 30 40 50 60 MDVISELVKK NGSKILLIVL DGLGGLPVKE GKTELELAKT PNLDKLVKNS ATGLHIPVDW 70 80 90 100 110 120 GITPGSGPGH LGLFGYDPIK YQIGRGILEA LGLGIDVKDT DIAVRGNYAT VEYRNGKPIV 130 140 150 160 170 180 VDRRAGRIPT EENKRITAKL QEAIKEIDGV QVIIKPGMEH RLAIVFRFPE KLSPGSDAIN 190 200 210 220 230 240 DTDPQQVGKE PLEPKGENPN AEKVAEVVRK FIQRATEILR NEPKANYILL RGFSQKPDIP 250 260 270 280 290 300 TMEERFGVKP CCIAVYPMYK GLASLVGMDV IEFEGSTIQD EIDTLKKVWN EYDYFFVHIK 310 320 330 340 350 360 KTDSYGEDGN YEGKVSVIED FDAHLPQFLE LKPDVLAITG DHSTPSILKG HSWHPVPLLI 370 380 390 400 HSPYVLGGTS ERFTERECLK GELGIIPAVK ITQLLLANAL RLKKYGA

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06791.1.
PIR	H70348.
RefSeq	NP_213380.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O66820.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193238.
GenomeReviews	Gene locus aq_542 in contig AE000657_GR.
KEGG	aae:aq_542.
NMPDR	fig|224324.1.peg.395.
PATRIC	20958620. VBIAquAeo85532_0445.
Phylogenomic databases
HOGENOM	HBG463247.
OMA	DIAFRCN.
PhylomeDB	O66820.
ProtClustDB	PRK04135.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_542-MONOMER.
Family and domain databases
HAMAP	MF_01402_B. ApgM_B. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_AQUAE

Accession

Primary (citable) accession number: O66820

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program