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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135GTPUniRule annotation1 Publication1
Binding sitei139GTPUniRule annotation1
Binding sitei183GTPUniRule annotation1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 21GTPUniRule annotation1 Publication5
Nucleotide bindingi104 – 106GTPUniRule annotation1 Publication3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotation
Ordered Locus Names:aq_525
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001143381 – 367Cell division protein FtsZAdd BLAST367

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_525.

Chemistry databases

BindingDBiO66809.

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Helixi16 – 28Combined sources13
Beta strandi35 – 42Combined sources8
Helixi43 – 47Combined sources5
Beta strandi52 – 56Combined sources5
Helixi59 – 62Combined sources4
Helixi71 – 80Combined sources10
Helixi82 – 89Combined sources8
Beta strandi93 – 100Combined sources8
Helixi105 – 119Combined sources15
Beta strandi123 – 130Combined sources8
Helixi133 – 135Combined sources3
Helixi137 – 152Combined sources16
Beta strandi155 – 161Combined sources7
Helixi162 – 167Combined sources6
Helixi175 – 198Combined sources24
Helixi207 – 214Combined sources8
Beta strandi218 – 229Combined sources12
Helixi232 – 242Combined sources11
Beta strandi244 – 249Combined sources6
Helixi251 – 253Combined sources3
Beta strandi255 – 263Combined sources9
Helixi271 – 282Combined sources12
Beta strandi288 – 295Combined sources8
Beta strandi301 – 310Combined sources10
Beta strandi317 – 319Combined sources3
Beta strandi322 – 324Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R6RX-ray1.7011-331[»]
2R75X-ray1.4011-331[»]
ProteinModelPortaliO66809.
SMRiO66809.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66809.

Family & Domainsi

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiO66809.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiPOG091H02KK.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEFVNPCKI KVIGVGGGGS NAVNRMYEDG IEGVELYAIN TDVQHLSTLK
60 70 80 90 100
VPNKIQIGEK VTRGLGAGAK PEVGEEAALE DIDKIKEILR DTDMVFISAG
110 120 130 140 150
LGGGTGTGAA PVIAKTAKEM GILTVAVATL PFRFEGPRKM EKALKGLEKL
160 170 180 190 200
KESSDAYIVI HNDKIKELSN RTLTIKDAFK EVDSVLSKAV RGITSIVVTP
210 220 230 240 250
AVINVDFADV RTTLEEGGLS IIGMGEGRGD EKADIAVEKA VTSPLLEGNT
260 270 280 290 300
IEGARRLLVT IWTSEDIPYD IVDEVMERIH SKVHPEAEII FGAVLEPQEQ
310 320 330 340 350
DFIRVAIVAT DFPEEKFQVG EKEVKFKVIK KEEKEEPKEE PKPLSDTTYL
360
EEEEIPAVIR RKNKRLL
Length:367
Mass (Da):40,161
Last modified:August 1, 1998 - v1
Checksum:i0DEC8A6A865348A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06771.1.
PIRiE70347.
RefSeqiNP_213369.1. NC_000918.1.
WP_010880307.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06771; AAC06771; aq_525.
GeneIDi1193227.
KEGGiaae:aq_525.
PATRICi20958592. VBIAquAeo85532_0431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06771.1.
PIRiE70347.
RefSeqiNP_213369.1. NC_000918.1.
WP_010880307.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R6RX-ray1.7011-331[»]
2R75X-ray1.4011-331[»]
ProteinModelPortaliO66809.
SMRiO66809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_525.

Chemistry databases

BindingDBiO66809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06771; AAC06771; aq_525.
GeneIDi1193227.
KEGGiaae:aq_525.
PATRICi20958592. VBIAquAeo85532_0431.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
InParanoidiO66809.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiPOG091H02KK.

Miscellaneous databases

EvolutionaryTraceiO66809.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiPS01134. FTSZ_1. 1 hit.
PS01135. FTSZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSZ_AQUAE
AccessioniPrimary (citable) accession number: O66809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.