O66788 (O66788_AQUAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating RuleBase RU000485
EC=1.1.1.44 RuleBase RU000485

Gene names

Name:	gnd EMBL AAC06739.1
Ordered Locus Names:	aq_498

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. RuleBase RU000485
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family. RuleBase RU000485

Ontologies

Keywords
Ligand	NADP RuleBase RU000485
Molecular function	Oxidoreductase RuleBase RU000485
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O66788 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6830777DD510A9FD	FASTA	300	34,191
	10 20 30 40 50 60 MKTLFLIGLG RMGSALAYRL KNRGWEIYGY SRTQTTRERA KKDLGIKVLN SYENLKNFPS 70 80 90 100 110 120 PKTVWLMVPH TAVDEVLQNL KPFLNKGDTV IDGGNSYYKD SQRRYRELKE VDVNFLDVGV 130 140 150 160 170 180 SGGILGKDTG FSFMIGGDEE VFKKHEKLFK DLAYEEKGYA YLGSSGAGHF AKMVHNGIEY 190 200 210 220 230 240 GIMEAIAEGF ELLKKSPFDY DLREVARVYS QGSVIRSFLI DLLVKAFEDF GDLEDVEGYV 250 260 270 280 290 300 EDSGEGRWCV KESVELGAPI PVIAQSFYER FSSREKDLFK NKVLAVLRYE FGRHRVKKKD

References

[1]	"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06739.1.
PIR	H70344.
RefSeq	NP_213348.1. NC_000918.1.
3D structure databases
HSSP	HSSP built from PDB template 2PGD based on UniProtKB P00349.
ProteinModelPortal	O66788.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193206.
GenomeReviews	Gene locus aq_498 in contig AE000657_GR.
KEGG	aae:aq_498.
NMPDR	fig|224324.1.peg.363.
PATRIC	20958548. VBIAquAeo85532_0409.
Phylogenomic databases
HOGENOM	HBG286913.
OMA	HEDKHEV.
PhylomeDB	O66788.
ProtClustDB	PRK09599.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR004849. 6DGDH-related. IPR006114. 6PGDH_C. IPR006115. 6PGDH_NADP-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00033.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00872. Gnd_rel. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O66788_AQUAE

Accession

Primary (citable) accession number: O66788

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)