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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathway: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (gsdA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADPUniRule annotation
Binding sitei127 – 1271NADPUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Binding sitei195 – 1951SubstrateUniRule annotation
Binding sitei214 – 2141SubstrateUniRule annotation
Active sitei219 – 2191Proton acceptorUniRule annotation
Binding sitei294 – 2941SubstrateUniRule annotation
Binding sitei299 – 2991SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-367-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:gsdAImported
Synonyms:zwfUniRule annotation
Ordered Locus Names:aq_497Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_497.

Structurei

3D structure databases

ProteinModelPortaliO66787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046192.
InParanoidiO66787.
KOiK00036.
OMAiLYCVTAV.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.

Sequencei

Sequence statusi: Complete.

O66787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGDTELRK RIEFIIFGGT GDLSRNKLIP AILKLKDKID LKKIYILGRN
60 70 80 90 100
RKKFEEIKEK FKDFSELFVF VEFLAEREES YKNISSILGK ESLKVFYLAV
110 120 130 140 150
PPDLFKEILE NVGKYLNFPE KRIVIEKPFG LSLKHAKDLN KIISVYFKEE
160 170 180 190 200
EIFRIDHYLG KPQVQNILAF KFSNYVFSEV LNKCLVEKVE VIALEEVGVE
210 220 230 240 250
GRKAYYEKVG VIRDMLQNHM LLLSSLIVMR LPPRAEDFHF ELKNALKRAE
260 270 280 290 300
FESESLILGK YKSYQGKAPT FALVKLHFDD ERFTGVPFVL ATGKKLKKKL
310 320 330 340 350
TRVCIHFKNF PKEIERLLGC VPERNLLVFE LYPEQEVSFR VNVISPLGFL
360 370 380 390 400
RCTESINWRV SLKDVLGEIP EAYESLLLDV IRGDKTLFLD AEETEILWEK
410 420 430
TEPLLKKEKE VLTYDDRVLI PEFAEDFISC L
Length:431
Mass (Da):50,232
Last modified:August 1, 1998 - v1
Checksum:i371B8E4ABEE03658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06740.1.
PIRiG70344.
RefSeqiNP_213347.1. NC_000918.1.
WP_010880285.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06740; AAC06740; aq_497.
GeneIDi1193205.
KEGGiaae:aq_497.
PATRICi20958546. VBIAquAeo85532_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06740.1.
PIRiG70344.
RefSeqiNP_213347.1. NC_000918.1.
WP_010880285.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06740; AAC06740; aq_497.
GeneIDi1193205.
KEGGiaae:aq_497.
PATRICi20958546. VBIAquAeo85532_0408.

Phylogenomic databases

HOGENOMiHOG000046192.
InParanoidiO66787.
KOiK00036.
OMAiLYCVTAV.
OrthoDBiEOG61308Z.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.
BioCyciAAEO224324:GJBH-367-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.

Entry informationi

Entry nameiO66787_AQUAE
AccessioniPrimary (citable) accession number: O66787
Secondary accession number(s): Q79LP1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 27, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.