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O66787 (O66787_AQUAE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966

Short name=G6PD HAMAP-Rule MF_00966
EC=1.1.1.49 HAMAP-Rule MF_00966
Gene names
Name:gsdA EMBL AAC06740.1
Synonyms:zwf HAMAP-Rule MF_00966
Ordered Locus Names:aq_497 EMBL AAC06740.1
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP] EMBL AAC06740.1
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. RuleBase RU000497 HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. RuleBase RU000497 HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family. RuleBase RU000497 HAMAP-Rule MF_00966

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding18 – 258NADP By similarity HAMAP-Rule MF_00966

Sites

Active site2191Proton acceptor By similarity HAMAP-Rule MF_00966
Binding site511NADP By similarity HAMAP-Rule MF_00966
Binding site1271NADP By similarity HAMAP-Rule MF_00966
Binding site1571Substrate By similarity HAMAP-Rule MF_00966
Binding site1611Substrate By similarity HAMAP-Rule MF_00966
Binding site1951Substrate By similarity HAMAP-Rule MF_00966
Binding site2141Substrate By similarity HAMAP-Rule MF_00966
Binding site2941Substrate By similarity HAMAP-Rule MF_00966
Binding site2991Substrate By similarity HAMAP-Rule MF_00966

Sequences

Sequence LengthMass (Da)Tools
O66787 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 371B8E4ABEE03658

FASTA43150,232
        10         20         30         40         50         60 
MSSGDTELRK RIEFIIFGGT GDLSRNKLIP AILKLKDKID LKKIYILGRN RKKFEEIKEK 

        70         80         90        100        110        120 
FKDFSELFVF VEFLAEREES YKNISSILGK ESLKVFYLAV PPDLFKEILE NVGKYLNFPE 

       130        140        150        160        170        180 
KRIVIEKPFG LSLKHAKDLN KIISVYFKEE EIFRIDHYLG KPQVQNILAF KFSNYVFSEV 

       190        200        210        220        230        240 
LNKCLVEKVE VIALEEVGVE GRKAYYEKVG VIRDMLQNHM LLLSSLIVMR LPPRAEDFHF 

       250        260        270        280        290        300 
ELKNALKRAE FESESLILGK YKSYQGKAPT FALVKLHFDD ERFTGVPFVL ATGKKLKKKL 

       310        320        330        340        350        360 
TRVCIHFKNF PKEIERLLGC VPERNLLVFE LYPEQEVSFR VNVISPLGFL RCTESINWRV 

       370        380        390        400        410        420 
SLKDVLGEIP EAYESLLLDV IRGDKTLFLD AEETEILWEK TEPLLKKEKE VLTYDDRVLI 

       430 
PEFAEDFISC L 

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References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olson G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5 EMBL AAC06740.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC06740.1.
PIRG70344.
RefSeqNP_213347.1. NC_000918.1.

3D structure databases

ProteinModelPortalO66787.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC06740; AAC06740; aq_497.
GeneID1193205.
KEGGaae:aq_497.
PATRIC20958546. VBIAquAeo85532_0408.

Phylogenomic databases

HOGENOMHOG000046192.
KOK00036.
OMAWRWVEPL.
OrthoDBEOG61308Z.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-367-MONOMER.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
ProtoNetSearch...

Entry information

Entry nameO66787_AQUAE
AccessionPrimary (citable) accession number: O66787
Secondary accession number(s): Q79LP1
Entry history
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)