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O66787

- O66787_AQUAE

UniProt

O66787 - O66787_AQUAE

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADPUniRule annotation
Binding sitei127 – 1271NADPUniRule annotation
Binding sitei157 – 1571SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Binding sitei195 – 1951SubstrateUniRule annotation
Binding sitei214 – 2141SubstrateUniRule annotation
Active sitei219 – 2191Proton acceptorUniRule annotation
Binding sitei294 – 2941SubstrateUniRule annotation
Binding sitei299 – 2991SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 258NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-367-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:gsdAImported
Synonyms:zwfUniRule annotation
Ordered Locus Names:aq_497Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_497.

Structurei

3D structure databases

ProteinModelPortaliO66787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046192.
InParanoidiO66787.
KOiK00036.
OMAiWRWVEPL.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.

Sequencei

Sequence statusi: Complete.

O66787-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSGDTELRK RIEFIIFGGT GDLSRNKLIP AILKLKDKID LKKIYILGRN
60 70 80 90 100
RKKFEEIKEK FKDFSELFVF VEFLAEREES YKNISSILGK ESLKVFYLAV
110 120 130 140 150
PPDLFKEILE NVGKYLNFPE KRIVIEKPFG LSLKHAKDLN KIISVYFKEE
160 170 180 190 200
EIFRIDHYLG KPQVQNILAF KFSNYVFSEV LNKCLVEKVE VIALEEVGVE
210 220 230 240 250
GRKAYYEKVG VIRDMLQNHM LLLSSLIVMR LPPRAEDFHF ELKNALKRAE
260 270 280 290 300
FESESLILGK YKSYQGKAPT FALVKLHFDD ERFTGVPFVL ATGKKLKKKL
310 320 330 340 350
TRVCIHFKNF PKEIERLLGC VPERNLLVFE LYPEQEVSFR VNVISPLGFL
360 370 380 390 400
RCTESINWRV SLKDVLGEIP EAYESLLLDV IRGDKTLFLD AEETEILWEK
410 420 430
TEPLLKKEKE VLTYDDRVLI PEFAEDFISC L
Length:431
Mass (Da):50,232
Last modified:August 1, 1998 - v1
Checksum:i371B8E4ABEE03658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06740.1.
PIRiG70344.
RefSeqiNP_213347.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06740; AAC06740; aq_497.
GeneIDi1193205.
KEGGiaae:aq_497.
PATRICi20958546. VBIAquAeo85532_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06740.1 .
PIRi G70344.
RefSeqi NP_213347.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06740 ; AAC06740 ; aq_497 .
GeneIDi 1193205.
KEGGi aae:aq_497.
PATRICi 20958546. VBIAquAeo85532_0408.

Phylogenomic databases

HOGENOMi HOG000046192.
InParanoidi O66787.
KOi K00036.
OMAi WRWVEPL.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci AAEO224324:GJBH-367-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.

Entry informationi

Entry nameiO66787_AQUAE
AccessioniPrimary (citable) accession number: O66787
Secondary accession number(s): Q79LP1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3