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O66787

- O66787_AQUAE

UniProt

O66787 - O66787_AQUAE

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511NADPUniRule annotation
    Binding sitei127 – 1271NADPUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Binding sitei195 – 1951SubstrateUniRule annotation
    Binding sitei214 – 2141SubstrateUniRule annotation
    Active sitei219 – 2191Proton acceptorUniRule annotation
    Binding sitei294 – 2941SubstrateUniRule annotation
    Binding sitei299 – 2991SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi18 – 258NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-367-MONOMER.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:gsdAImported
    Synonyms:zwfUniRule annotation
    Ordered Locus Names:aq_497Imported
    OrganismiAquifex aeolicus (strain VF5)Imported
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_497.

    Structurei

    3D structure databases

    ProteinModelPortaliO66787.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000046192.
    KOiK00036.
    OMAiWRWVEPL.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.

    Sequencei

    Sequence statusi: Complete.

    O66787-1 [UniParc]FASTAAdd to Basket

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    MSSGDTELRK RIEFIIFGGT GDLSRNKLIP AILKLKDKID LKKIYILGRN    50
    RKKFEEIKEK FKDFSELFVF VEFLAEREES YKNISSILGK ESLKVFYLAV 100
    PPDLFKEILE NVGKYLNFPE KRIVIEKPFG LSLKHAKDLN KIISVYFKEE 150
    EIFRIDHYLG KPQVQNILAF KFSNYVFSEV LNKCLVEKVE VIALEEVGVE 200
    GRKAYYEKVG VIRDMLQNHM LLLSSLIVMR LPPRAEDFHF ELKNALKRAE 250
    FESESLILGK YKSYQGKAPT FALVKLHFDD ERFTGVPFVL ATGKKLKKKL 300
    TRVCIHFKNF PKEIERLLGC VPERNLLVFE LYPEQEVSFR VNVISPLGFL 350
    RCTESINWRV SLKDVLGEIP EAYESLLLDV IRGDKTLFLD AEETEILWEK 400
    TEPLLKKEKE VLTYDDRVLI PEFAEDFISC L 431
    Length:431
    Mass (Da):50,232
    Last modified:August 1, 1998 - v1
    Checksum:i371B8E4ABEE03658
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06740.1.
    PIRiG70344.
    RefSeqiNP_213347.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC06740; AAC06740; aq_497.
    GeneIDi1193205.
    KEGGiaae:aq_497.
    PATRICi20958546. VBIAquAeo85532_0408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06740.1 .
    PIRi G70344.
    RefSeqi NP_213347.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O66787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_497.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC06740 ; AAC06740 ; aq_497 .
    GeneIDi 1193205.
    KEGGi aae:aq_497.
    PATRICi 20958546. VBIAquAeo85532_0408.

    Phylogenomic databases

    HOGENOMi HOG000046192.
    KOi K00036.
    OMAi WRWVEPL.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    BioCyci AAEO224324:GJBH-367-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5Imported.

    Entry informationi

    Entry nameiO66787_AQUAE
    AccessioniPrimary (citable) accession number: O66787
    Secondary accession number(s): Q79LP1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 1, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3