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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

gsdA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (gsdA)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51NADPUniRule annotation1
Binding sitei127NADPUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Binding sitei195SubstrateUniRule annotation1
Binding sitei214SubstrateUniRule annotation1
Active sitei219Proton acceptorUniRule annotation1
Binding sitei294SubstrateUniRule annotation1
Binding sitei299SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 25NADPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:gsdAImported
Synonyms:zwfUniRule annotation
Ordered Locus Names:aq_497Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_497.

Structurei

3D structure databases

ProteinModelPortaliO66787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 166G6PD_NInterPro annotationAdd BLAST152
Domaini168 – 427G6PD_CInterPro annotationAdd BLAST260

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
HOGENOMiHOG000046192.
InParanoidiO66787.
KOiK00036.
OMAiDNIYENT.
OrthoDBiPOG091H04ZM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

O66787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGDTELRK RIEFIIFGGT GDLSRNKLIP AILKLKDKID LKKIYILGRN
60 70 80 90 100
RKKFEEIKEK FKDFSELFVF VEFLAEREES YKNISSILGK ESLKVFYLAV
110 120 130 140 150
PPDLFKEILE NVGKYLNFPE KRIVIEKPFG LSLKHAKDLN KIISVYFKEE
160 170 180 190 200
EIFRIDHYLG KPQVQNILAF KFSNYVFSEV LNKCLVEKVE VIALEEVGVE
210 220 230 240 250
GRKAYYEKVG VIRDMLQNHM LLLSSLIVMR LPPRAEDFHF ELKNALKRAE
260 270 280 290 300
FESESLILGK YKSYQGKAPT FALVKLHFDD ERFTGVPFVL ATGKKLKKKL
310 320 330 340 350
TRVCIHFKNF PKEIERLLGC VPERNLLVFE LYPEQEVSFR VNVISPLGFL
360 370 380 390 400
RCTESINWRV SLKDVLGEIP EAYESLLLDV IRGDKTLFLD AEETEILWEK
410 420 430
TEPLLKKEKE VLTYDDRVLI PEFAEDFISC L
Length:431
Mass (Da):50,232
Last modified:August 1, 1998 - v1
Checksum:i371B8E4ABEE03658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06740.1.
PIRiG70344.
RefSeqiNP_213347.1. NC_000918.1.
WP_010880285.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06740; AAC06740; aq_497.
GeneIDi1193205.
KEGGiaae:aq_497.
PATRICi20958546. VBIAquAeo85532_0408.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06740.1.
PIRiG70344.
RefSeqiNP_213347.1. NC_000918.1.
WP_010880285.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06740; AAC06740; aq_497.
GeneIDi1193205.
KEGGiaae:aq_497.
PATRICi20958546. VBIAquAeo85532_0408.

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
HOGENOMiHOG000046192.
InParanoidiO66787.
KOiK00036.
OMAiDNIYENT.
OrthoDBiPOG091H04ZM.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiO66787_AQUAE
AccessioniPrimary (citable) accession number: O66787
Secondary accession number(s): Q79LP1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.