Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein GrpE

Gene

grpE

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:aq_433
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001137341 – 182Protein GrpEAdd BLAST182

Proteomic databases

PRIDEiO66745.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi224324.aq_433.

Structurei

3D structure databases

ProteinModelPortaliO66745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41082NI. Bacteria.
COG0576. LUCA.
HOGENOMiHOG000252083.
InParanoidiO66745.
KOiK03687.
OMAiARDMIDS.
OrthoDBiPOG091H00J8.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKNQKEIEK ELEELRKREK ELEEKIQKLE TIAKNSNLRV AELQREIDYL
60 70 80 90 100
KERYRRDLEE QRKFCYEKFA YDLLEVMDNF ERALEYGRQA QDVKSILLGI
110 120 130 140 150
EMIYSEMKKI FEKYGIREIP VEGKEFDPYV AEAVEKVETD QYPPNTVVKV
160 170 180
IRKGYYIHDK VLRPARVAVA VPPQEEEGEE IT
Length:182
Mass (Da):21,812
Last modified:August 1, 1998 - v1
Checksum:i70CD1B510BA818D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06707.1.
PIRiE70339.
RefSeqiNP_213305.1. NC_000918.1.
WP_010880243.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06707; AAC06707; aq_433.
GeneIDi1193071.
KEGGiaae:aq_433.
PATRICi20958444. VBIAquAeo85532_0358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06707.1.
PIRiE70339.
RefSeqiNP_213305.1. NC_000918.1.
WP_010880243.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO66745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_433.

Proteomic databases

PRIDEiO66745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06707; AAC06707; aq_433.
GeneIDi1193071.
KEGGiaae:aq_433.
PATRICi20958444. VBIAquAeo85532_0358.

Phylogenomic databases

eggNOGiENOG41082NI. Bacteria.
COG0576. LUCA.
HOGENOMiHOG000252083.
InParanoidiO66745.
KOiK03687.
OMAiARDMIDS.
OrthoDBiPOG091H00J8.

Family and domain databases

CDDicd00446. GrpE. 1 hit.
Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE. 1 hit.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRPE_AQUAE
AccessioniPrimary (citable) accession number: O66745
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.