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Protein

D-aminoacyl-tRNA deacylase

Gene

dtd

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.UniRule annotation

Catalytic activityi

A D-aminoacyl-tRNA + H2O = a D-amino acid + tRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei80NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
D-aminoacyl-tRNA deacylaseUniRule annotation (EC:3.1.1.96UniRule annotation)
Alternative name(s):
D-tyrosyl-tRNA(Tyr) deacylase
Gene namesi
Name:dtdUniRule annotation
Ordered Locus Names:aq_428
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationCurated

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001645131 – 148D-aminoacyl-tRNA deacylaseAdd BLAST148

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_428.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 15Combined sources14
Beta strandi18 – 32Combined sources15
Helixi39 – 51Combined sources13
Turni66 – 70Combined sources5
Beta strandi72 – 77Combined sources6
Helixi79 – 82Combined sources4
Beta strandi86 – 90Combined sources5
Helixi99 – 114Combined sources16
Beta strandi120 – 122Combined sources3
Beta strandi125 – 127Combined sources3
Beta strandi130 – 144Combined sources15
Helixi145 – 147Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBOX-ray2.76A1-148[»]
ProteinModelPortaliO66742.
SMRiO66742.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66742.

Family & Domainsi

Sequence similaritiesi

Belongs to the DTD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YYA. Bacteria.
COG1490. LUCA.
HOGENOMiHOG000113981.
InParanoidiO66742.
KOiK07560.
OMAiDGPVTIW.
OrthoDBiPOG091H02D0.

Family and domain databases

CDDicd00563. Dtyr_deacylase. 1 hit.
Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.

Sequencei

Sequence statusi: Complete.

O66742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAVIQRVKK SWVEVDGKVV GSINEGLNVF LGVRKGDTEE DIEKLVNKIL
60 70 80 90 100
NLRIFEDERG KFQYSVLDIK GEILVVSQFT LYANVKKGRR PSFEEAEEPK
110 120 130 140
RAKELYEKFV DKIKESGLKV ETGIFGAMMD VFIENWGPVT IIIDSREI
Length:148
Mass (Da):16,968
Last modified:August 1, 1998 - v1
Checksum:i24A3324C96C21234
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06704.1.
PIRiB70339.
RefSeqiNP_213302.1. NC_000918.1.
WP_010880240.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06704; AAC06704; aq_428.
GeneIDi1193068.
KEGGiaae:aq_428.
PATRICi20958434. VBIAquAeo85532_0353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06704.1.
PIRiB70339.
RefSeqiNP_213302.1. NC_000918.1.
WP_010880240.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DBOX-ray2.76A1-148[»]
ProteinModelPortaliO66742.
SMRiO66742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06704; AAC06704; aq_428.
GeneIDi1193068.
KEGGiaae:aq_428.
PATRICi20958434. VBIAquAeo85532_0353.

Phylogenomic databases

eggNOGiENOG4108YYA. Bacteria.
COG1490. LUCA.
HOGENOMiHOG000113981.
InParanoidiO66742.
KOiK07560.
OMAiDGPVTIW.
OrthoDBiPOG091H02D0.

Miscellaneous databases

EvolutionaryTraceiO66742.

Family and domain databases

CDDicd00563. Dtyr_deacylase. 1 hit.
Gene3Di3.50.80.10. 1 hit.
HAMAPiMF_00518. Deacylase_Dtd. 1 hit.
InterProiIPR003732. Daa-tRNA_deacyls_DTD.
IPR023509. DTD-like_dom.
[Graphical view]
PANTHERiPTHR10472. PTHR10472. 1 hit.
PfamiPF02580. Tyr_Deacylase. 1 hit.
[Graphical view]
SUPFAMiSSF69500. SSF69500. 1 hit.
TIGRFAMsiTIGR00256. TIGR00256. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDTD_AQUAE
AccessioniPrimary (citable) accession number: O66742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.