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Protein
Submitted name:

Poly A polymerase

Gene

pcnB1

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei462CTPCombined sources1
Binding sitei603ATPCombined sources1
Binding sitei603CTPCombined sources1
Binding sitei632ATPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi459 – 462ATPCombined sources4
Nucleotide bindingi545 – 546ATPCombined sources2
Nucleotide bindingi545 – 546CTPCombined sources2
Nucleotide bindingi590 – 599ATPCombined sources10
Nucleotide bindingi590 – 596CTPCombined sources7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

ATP-bindingCombined sources, Nucleotide-binding, RNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Poly A polymeraseImported
Gene namesi
Name:pcnB1Imported
Ordered Locus Names:aq_411Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_411.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VFGX-ray2.80A/B443-824[»]
4WBYX-ray1.50A428-824[»]
4WBZX-ray3.30A/B443-824[»]
4WC0X-ray3.10A/B443-824[»]
4WC1X-ray3.10A/B443-824[»]
4WC2X-ray2.80A443-824[»]
4WC3X-ray3.10A443-824[»]
4WC4X-ray3.50A443-824[»]
4WC5X-ray3.41A443-824[»]
4WC6X-ray3.41A443-824[»]
4WC7X-ray3.10A443-824[»]
4X0AX-ray3.50A443-824[»]
4X0BX-ray3.20A443-824[»]
ProteinModelPortaliO66728.
SMRiO66728.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66728.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini305 – 363CBSInterPro annotationAdd BLAST59
Domaini367 – 423CBSInterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili731 – 758Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105D4J. Bacteria.
COG0517. LUCA.
COG0617. LUCA.
COG0618. LUCA.
HOGENOMiHOG000011569.
InParanoidiO66728.
KOiK00974.
OMAiPSWVRET.
OrthoDBiPOG091H022U.

Family and domain databases

CDDicd05398. NT_ClassII-CCAase. 1 hit.
InterProiIPR000644. CBS_dom.
IPR001667. DDH_dom.
IPR003156. DHHA1_dom.
IPR002646. PolA_pol_head_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01368. DHH. 1 hit.
PF02272. DHHA1. 1 hit.
PF01743. PolyA_pol. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66728-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCPKVVILS EGADLDSLSA AYGVLKLYPD AYLLKPKHLS KKAGEVFKKY
60 70 80 90 100
RDKFRVIEDL PDCFELVLVD THFLPEGLPR ERIKRIIVYD HHPIGDVKEF
110 120 130 140 150
EGKIEKVGAA TTLVVEEIKE KGIDINPRDA TLLAFGIYED TGNFTYEGTT
160 170 180 190 200
PRDALALAFL LEKGANLREI REVVMETYTP EQIEAVGKIV QSIEKVFING
210 220 230 240 250
RQISFATAVL ERYQPDINTL LYEIKDLKES DAFFVIIEAE GKTYVFGRSQ
260 270 280 290 300
SEDVDVGEIL SHFGGGGHRE AGAVKLENVS AERIKELIKA FLKRKYVKLK
310 320 330 340 350
VRDIMNTPPF VLEEHVSVKD ALTELSERGI ANAPVINREG KLVGIISKKA
360 370 380 390 400
LLKLVKLYPD EPIELFVNRD FYTLSPDAPV WEAEEILTKF GQKLIPVVED
410 420 430 440 450
GTVVGVVTRL DILQAVKEDL EKLKEKRRKI KVPENIEEIA REVGQIAKEM
460 470 480 490 500
GLRAYIVGGV VRDILLGKEV WDVDFVVEGN AIELAKELAR RHGVNVHPFP
510 520 530 540 550
EFGTAHLKIG KLKLEFATAR RETYPRPGAY PKVEPASLKE DLIRRDFTIN
560 570 580 590 600
AMAISVNLED YGTLIDYFGG LRDLKDKVIR VLHPVSFIED PVRILRALRF
610 620 630 640 650
AGRLNFKLSR STEKLLKQAV NLGLLKEAPR GRLINEIKLA LREDRFLEIL
660 670 680 690 700
ELYRKYRVLE EIIEGFQWNE KVLQKLYALR KVVDWHALEF SEERIDYGWL
710 720 730 740 750
YLLILISNLD YERGKHFLEE MSAPSWVRET YKFMKFKLGS LKEELKKAKE
760 770 780 790 800
NYEVYRLLKP LHTSVLLLLM LEEELKEKIK LYLEKLRKVK LPKEKIEELK
810 820
KQGLKGKELG ERIEELKREI MNKI
Length:824
Mass (Da):94,658
Last modified:August 1, 1998 - v1
Checksum:iA5B627695C2DAF73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06692.1.
PIRiD70337.
RefSeqiNP_213288.1. NC_000918.1.
WP_010880226.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06692; AAC06692; aq_411.
GeneIDi1193054.
KEGGiaae:aq_411.
PATRICi20958404. VBIAquAeo85532_0338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06692.1.
PIRiD70337.
RefSeqiNP_213288.1. NC_000918.1.
WP_010880226.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VFGX-ray2.80A/B443-824[»]
4WBYX-ray1.50A428-824[»]
4WBZX-ray3.30A/B443-824[»]
4WC0X-ray3.10A/B443-824[»]
4WC1X-ray3.10A/B443-824[»]
4WC2X-ray2.80A443-824[»]
4WC3X-ray3.10A443-824[»]
4WC4X-ray3.50A443-824[»]
4WC5X-ray3.41A443-824[»]
4WC6X-ray3.41A443-824[»]
4WC7X-ray3.10A443-824[»]
4X0AX-ray3.50A443-824[»]
4X0BX-ray3.20A443-824[»]
ProteinModelPortaliO66728.
SMRiO66728.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_411.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06692; AAC06692; aq_411.
GeneIDi1193054.
KEGGiaae:aq_411.
PATRICi20958404. VBIAquAeo85532_0338.

Phylogenomic databases

eggNOGiENOG4105D4J. Bacteria.
COG0517. LUCA.
COG0617. LUCA.
COG0618. LUCA.
HOGENOMiHOG000011569.
InParanoidiO66728.
KOiK00974.
OMAiPSWVRET.
OrthoDBiPOG091H022U.

Miscellaneous databases

EvolutionaryTraceiO66728.

Family and domain databases

CDDicd05398. NT_ClassII-CCAase. 1 hit.
InterProiIPR000644. CBS_dom.
IPR001667. DDH_dom.
IPR003156. DHHA1_dom.
IPR002646. PolA_pol_head_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01368. DHH. 1 hit.
PF02272. DHHA1. 1 hit.
PF01743. PolyA_pol. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO66728_AQUAE
AccessioniPrimary (citable) accession number: O66728
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.