O66682 (LY41_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized AIPM/Hcit synthase family transferase aq_356
EC=2.3.3.-

Gene names

Ordered Locus Names:

aq_356

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the alpha-IPM synthase/homocitrate synthase family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	leucine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-isopropylmalate synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 528	528	Uncharacterized AIPM/Hcit synthase family transferase aq_356		PRO_0000140469

Sequences

	Sequence		Length	Mass (Da)
	O66682 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 1BC6ABAEC35D3F34	FASTA	528	59,215
	10 20 30 40 50 60 MAEKVYIYDT TLRDGSQMEG VSFSLEDKIR IAEKLDDFGI HYIEGGWPYA NPKDNLFFQK 70 80 90 100 110 120 AKKMNFKNAK LTAFGSTRRP NKKVSEDPQV ESLIKAETPV VTIFGKSWDL HVTDALKTTL 130 140 150 160 170 180 EENLNMIYET VEYLKRYVDE VIFDAEHFFD GYKSNPEYAL QVLEAALKGG ADWVVLCDTN 190 200 210 220 230 240 GGTLPHEIYE ITKKVKERFK DANVGIHAHN DSETAVANSL MAVLAGARQV HGTINGIGER 250 260 270 280 290 300 TGNANLCSII PNLQLKLGFD VIPQENLKKL TELANFVAEI INMPLPRNMP YVGESAFAHK 310 320 330 340 350 360 GGVHASAVLK NAKTYEHINP ELVGNKRKIT VSDLAGRSNL VHKLKEFGIE IDPKSPELKK 370 380 390 400 410 420 LIDKIKELEK EGYHFEAAEA SLELLIKRHF GLVKDYFDFD AYRVLIAKRR DDSLPTSEAT 430 440 450 460 470 480 VRLSVEGVEE HTASLGNGPI SALDRALRKA LEEFYPNLKE LQLIDYKVRI INESAGTSAK 490 500 510 520 VRVLIESTDG KRKWGTVGVS ENVIEASWIA LRDSIVYKLM KDEEEGIL

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06637.1.
PIR	F70331.
RefSeq	NP_213242.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O66682.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1193008.
GenomeReviews	Gene locus aq_356 in contig AE000657_GR.
KEGG	aae:aq_356.
NMPDR	fig|224324.1.peg.257.
PATRIC	20958300. VBIAquAeo85532_0286.
Phylogenomic databases
HOGENOM	HBG701974.
OMA	YGERCGN.
PhylomeDB	O66682.
ProtClustDB	PRK12344.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_356-MONOMER.
Family and domain databases
InterPro	IPR013709. 2-isopropylmalate_synth_dimer. IPR002034. AIPM/Hcit_synth_CS. IPR013785. Aldolase_TIM. IPR005675. LeuA-rel. IPR000891. PYR_CT. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01649.
PANTHER	PTHR10277:SF5. LeuA_rel. 1 hit.
Pfam	PF00682. HMGL-like. 1 hit. PF08502. LeuA_dimer. 1 hit. [Graphical view]
SMART	SM00917. LeuA_dimer. 1 hit. [Graphical view]
SUPFAM	SSF110921. 2-isopropylmalate_synth_dimer. 1 hit.
TIGRFAMs	TIGR00977. LeuA_rel. 1 hit.
PROSITE	PS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit. PS00816. AIPM_HOMOCIT_SYNTH_2. False negative. PS50991. PYR_CT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LY41_AQUAE

Accession

Primary (citable) accession number: O66682

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program