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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi119 – 126ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:aq_322
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141221 – 399Chromosomal replication initiator protein DnaAAdd BLAST399

Interactioni

Protein-protein interaction databases

DIPiDIP-29219N.
STRINGi224324.aq_322.

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi85 – 87Combined sources3
Turni92 – 94Combined sources3
Helixi95 – 106Combined sources12
Turni107 – 110Combined sources4
Beta strandi113 – 118Combined sources6
Beta strandi120 – 124Combined sources5
Helixi125 – 138Combined sources14
Beta strandi143 – 147Combined sources5
Helixi148 – 161Combined sources14
Helixi164 – 172Combined sources9
Beta strandi175 – 180Combined sources6
Helixi182 – 185Combined sources4
Helixi189 – 204Combined sources16
Beta strandi208 – 215Combined sources8
Helixi217 – 219Combined sources3
Helixi225 – 232Combined sources8
Beta strandi234 – 238Combined sources5
Helixi243 – 256Combined sources14
Helixi263 – 272Combined sources10
Helixi276 – 289Combined sources14
Helixi291 – 316Combined sources26
Helixi320 – 323Combined sources4
Beta strandi330 – 332Combined sources3
Helixi333 – 347Combined sources15
Helixi351 – 357Combined sources7
Helixi365 – 375Combined sources11
Helixi383 – 398Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8QX-ray2.70A76-399[»]
2HCBX-ray3.51A/B/C/D77-399[»]
3R8FX-ray3.37A/B/C/D76-399[»]
ProteinModelPortaliO66659.
SMRiO66659.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66659.

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235658.
InParanoidiO66659.
KOiK02313.
OMAiRTISMIS.
OrthoDBiPOG091H02FF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELNALIKKI ESVDSYAREF LKKFEIKQEK GKFLFIAPGE DYREWLETIV
60 70 80 90 100
NTFLEEEVRK LIEVKEKEEK KKVEIKDFLN PKYTLENFIV GEGNRLAYEV
110 120 130 140 150
VKEALENLGS LYNPIFIYGS VGTGKTHLLQ AAGNEAKKRG YRVIYSSADD
160 170 180 190 200
FAQAMVEHLK KGTINEFRNM YKSVDLLLLD DVQFLSGKER TQIEFFHIFN
210 220 230 240 250
TLYLLEKQII LASDRHPQKL DGVSDRLVSR FEGGILVEIE LDNKTRFKII
260 270 280 290 300
KEKLKEFNLE LRKEVIDYLL ENTKNVREIE GKIKLIKLKG FEGLERKERK
310 320 330 340 350
ERDKLMQIVE FVANYYAVKV EDILSDKRNK RTSEARKIAM YLCRKVCSAS
360 370 380 390
LIEIARAFKR KDHTTVIHAI RSVEEEKKKD RKFKHLVGFL EKQAFDKIC
Length:399
Mass (Da):46,840
Last modified:August 1, 1998 - v1
Checksum:iC641CB199AA79906
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06612.1.
PIRiG70328.
RefSeqiNP_213219.1. NC_000918.1.
WP_010880157.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06612; AAC06612; aq_322.
GeneIDi1192893.
KEGGiaae:aq_322.
PATRICi20958240. VBIAquAeo85532_0259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06612.1.
PIRiG70328.
RefSeqiNP_213219.1. NC_000918.1.
WP_010880157.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L8QX-ray2.70A76-399[»]
2HCBX-ray3.51A/B/C/D77-399[»]
3R8FX-ray3.37A/B/C/D76-399[»]
ProteinModelPortaliO66659.
SMRiO66659.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29219N.
STRINGi224324.aq_322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06612; AAC06612; aq_322.
GeneIDi1192893.
KEGGiaae:aq_322.
PATRICi20958240. VBIAquAeo85532_0259.

Phylogenomic databases

eggNOGiENOG4105CI4. Bacteria.
COG0593. LUCA.
HOGENOMiHOG000235658.
InParanoidiO66659.
KOiK02313.
OMAiRTISMIS.
OrthoDBiPOG091H02FF.

Miscellaneous databases

EvolutionaryTraceiO66659.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_AQUAE
AccessioniPrimary (citable) accession number: O66659
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.