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O66648

- GLMS_AQUAE

UniProt

O66648 - GLMS_AQUAE

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, aq_301
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei587 – 5871For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-224-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:aq_301
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 592591Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135292Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_301.

Structurei

3D structure databases

ProteinModelPortaliO66648.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini277 – 416140SIS 1
Add
BLAST
Domaini441 – 582142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O66648-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYVGR DLALPIVLGA LERLEYRGYD SAGVALIEDG KLIVEKKKGK    50
IRELVKALWG KDYKAKTGIG HTRWATHGKP TDENAHPHTD EKGEFAVVHN 100
GIIENYLELK EELKKEGVKF RSETDTEVIA HLIAKNYRGD LLEAVLKTVK 150
KLKGAFAFAV ITVHEPNRLI GVKQGSPLIV GLGEGENFLA SDIPAILPYT 200
KKIIVLDDGE IADLTPDTVN IYNFEGEPVS KEVMITPWDL VSAEKGGFKH 250
FMLKEIYEQP KAINDTLKGF LSTEDAIPFK LKDFRRVLII ACGTSYHAGF 300
VGKYWIERFA GVPTEVIYAS EFRYADVPVS DKDIVIGISQ SGETADTKFA 350
LQSAKEKGAF TVGLVNVVGS AIDRESDFSL HTHAGPEIGV AATKTFTAQL 400
TALYALSVRE SEERENLIRL LEKVPSLVEQ TLNTAEEVEK VAEKYMKKKN 450
MLYLGRYLNY PIALEGALKL KEISYIHAEG YPAGEMKHGP IALIDENMPV 500
VVIAPKDRVY EKILSNVEEV LARKGRVISV GFKGDETLKS KSESVMEIPK 550
AEEPITPFLT VIPLQLFAYF IASKLGLDVD QPRNLAKTVT VE 592
Length:592
Mass (Da):65,493
Last modified:January 23, 2007 - v3
Checksum:iC66601823E2CFC02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06609.1.
PIRiD70327.
RefSeqiNP_213208.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06609; AAC06609; aq_301.
GeneIDi1192882.
KEGGiaae:aq_301.
PATRICi20958214. VBIAquAeo85532_0246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06609.1 .
PIRi D70327.
RefSeqi NP_213208.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66648.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_301.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06609 ; AAC06609 ; aq_301 .
GeneIDi 1192882.
KEGGi aae:aq_301.
PATRICi 20958214. VBIAquAeo85532_0246.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-224-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiGLMS_AQUAE
AccessioniPrimary (citable) accession number: O66648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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