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O66648

- GLMS_AQUAE

UniProt

O66648 - GLMS_AQUAE

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei587 – 5871For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-224-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:aq_301
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 592591Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135292Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_301.

Structurei

3D structure databases

ProteinModelPortaliO66648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini277 – 416140SIS 1UniRule annotationAdd
BLAST
Domaini441 – 582142SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
InParanoidiO66648.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O66648-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYVGR DLALPIVLGA LERLEYRGYD SAGVALIEDG KLIVEKKKGK
60 70 80 90 100
IRELVKALWG KDYKAKTGIG HTRWATHGKP TDENAHPHTD EKGEFAVVHN
110 120 130 140 150
GIIENYLELK EELKKEGVKF RSETDTEVIA HLIAKNYRGD LLEAVLKTVK
160 170 180 190 200
KLKGAFAFAV ITVHEPNRLI GVKQGSPLIV GLGEGENFLA SDIPAILPYT
210 220 230 240 250
KKIIVLDDGE IADLTPDTVN IYNFEGEPVS KEVMITPWDL VSAEKGGFKH
260 270 280 290 300
FMLKEIYEQP KAINDTLKGF LSTEDAIPFK LKDFRRVLII ACGTSYHAGF
310 320 330 340 350
VGKYWIERFA GVPTEVIYAS EFRYADVPVS DKDIVIGISQ SGETADTKFA
360 370 380 390 400
LQSAKEKGAF TVGLVNVVGS AIDRESDFSL HTHAGPEIGV AATKTFTAQL
410 420 430 440 450
TALYALSVRE SEERENLIRL LEKVPSLVEQ TLNTAEEVEK VAEKYMKKKN
460 470 480 490 500
MLYLGRYLNY PIALEGALKL KEISYIHAEG YPAGEMKHGP IALIDENMPV
510 520 530 540 550
VVIAPKDRVY EKILSNVEEV LARKGRVISV GFKGDETLKS KSESVMEIPK
560 570 580 590
AEEPITPFLT VIPLQLFAYF IASKLGLDVD QPRNLAKTVT VE
Length:592
Mass (Da):65,493
Last modified:January 23, 2007 - v3
Checksum:iC66601823E2CFC02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06609.1.
PIRiD70327.
RefSeqiNP_213208.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06609; AAC06609; aq_301.
GeneIDi1192882.
KEGGiaae:aq_301.
PATRICi20958214. VBIAquAeo85532_0246.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06609.1 .
PIRi D70327.
RefSeqi NP_213208.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66648.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_301.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06609 ; AAC06609 ; aq_301 .
GeneIDi 1192882.
KEGGi aae:aq_301.
PATRICi 20958214. VBIAquAeo85532_0246.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
InParanoidi O66648.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-224-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiGLMS_AQUAE
AccessioniPrimary (citable) accession number: O66648
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3