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Protein

Lipoprotein-releasing system ATP-binding protein LolD

Gene

lolD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein-releasing system ATP-binding protein LolDUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:lolDUniRule annotation
Ordered Locus Names:aq_297
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Lipoprotein-releasing system ATP-binding protein LolDPRO_0000092417Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_297.

Structurei

Secondary structure

1
224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1412Combined sources
Beta strandi17 – 2812Combined sources
Beta strandi32 – 376Combined sources
Helixi43 – 508Combined sources
Beta strandi57 – 637Combined sources
Helixi73 – 8311Combined sources
Beta strandi84 – 874Combined sources
Helixi99 – 10911Combined sources
Helixi114 – 12714Combined sources
Helixi138 – 1403Combined sources
Helixi143 – 15412Combined sources
Turni155 – 1573Combined sources
Beta strandi160 – 1667Combined sources
Turni167 – 1704Combined sources
Helixi173 – 18816Combined sources
Beta strandi192 – 1965Combined sources
Helixi200 – 2034Combined sources
Beta strandi206 – 2138Combined sources
Beta strandi216 – 2227Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PCJX-ray1.70A/B1-224[»]
2PCLX-ray1.70A1-224[»]
ProteinModelPortaliO66646.
SMRiO66646. Positions 2-224.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 224220ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107XPZ. Bacteria.
COG1136. LUCA.
InParanoidiO66646.
KOiK09810.
OMAiKESNIAF.
OrthoDBiPOG091H023H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015854. ABC_transpr_LolD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51244. LOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEILRAENI KKVIRGYEIL KGISLSVKKG EFVSIIGASG SGKSTLLYIL
60 70 80 90 100
GLLDAPTEGK VFLEGKEVDY TNEKELSLLR NRKLGFVFQF HYLIPELTAL
110 120 130 140 150
ENVIVPMLKM GKPKKEAKER GEYLLSELGL GDKLSRKPYE LSGGEQQRVA
160 170 180 190 200
IARALANEPI LLFADEPTGN LDSANTKRVM DIFLKINEGG TSIVMVTHER
210 220
ELAELTHRTL EMKDGKVVGE ITRV
Length:224
Mass (Da):24,887
Last modified:August 1, 1998 - v1
Checksum:i0804B347486A963C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06596.1.
PIRiB70327.
RefSeqiNP_213206.1. NC_000918.1.
WP_010880144.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06596; AAC06596; aq_297.
GeneIDi1192880.
KEGGiaae:aq_297.
PATRICi20958210. VBIAquAeo85532_0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06596.1.
PIRiB70327.
RefSeqiNP_213206.1. NC_000918.1.
WP_010880144.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PCJX-ray1.70A/B1-224[»]
2PCLX-ray1.70A1-224[»]
ProteinModelPortaliO66646.
SMRiO66646. Positions 2-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06596; AAC06596; aq_297.
GeneIDi1192880.
KEGGiaae:aq_297.
PATRICi20958210. VBIAquAeo85532_0244.

Phylogenomic databases

eggNOGiENOG4107XPZ. Bacteria.
COG1136. LUCA.
InParanoidiO66646.
KOiK09810.
OMAiKESNIAF.
OrthoDBiPOG091H023H.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-222-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO66646.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015854. ABC_transpr_LolD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51244. LOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOLD_AQUAE
AccessioniPrimary (citable) accession number: O66646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.