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Protein

Lipoprotein-releasing system ATP-binding protein LolD

Gene

lolD

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44ATPUniRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein-releasing system ATP-binding protein LolDUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:lolDUniRule annotation
Ordered Locus Names:aq_297
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924171 – 224Lipoprotein-releasing system ATP-binding protein LolDAdd BLAST224

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_297.

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 14Combined sources12
Beta strandi17 – 28Combined sources12
Beta strandi32 – 37Combined sources6
Helixi43 – 50Combined sources8
Beta strandi57 – 63Combined sources7
Helixi73 – 83Combined sources11
Beta strandi84 – 87Combined sources4
Helixi99 – 109Combined sources11
Helixi114 – 127Combined sources14
Helixi138 – 140Combined sources3
Helixi143 – 154Combined sources12
Turni155 – 157Combined sources3
Beta strandi160 – 166Combined sources7
Turni167 – 170Combined sources4
Helixi173 – 188Combined sources16
Beta strandi192 – 196Combined sources5
Helixi200 – 203Combined sources4
Beta strandi206 – 213Combined sources8
Beta strandi216 – 222Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PCJX-ray1.70A/B1-224[»]
2PCLX-ray1.70A1-224[»]
ProteinModelPortaliO66646.
SMRiO66646.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO66646.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 224ABC transporterUniRule annotationAdd BLAST220

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107XPZ. Bacteria.
COG1136. LUCA.
InParanoidiO66646.
KOiK09810.
OMAiKESNIAF.
OrthoDBiPOG091H023H.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015854. ABC_transpr_LolD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51244. LOLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEILRAENI KKVIRGYEIL KGISLSVKKG EFVSIIGASG SGKSTLLYIL
60 70 80 90 100
GLLDAPTEGK VFLEGKEVDY TNEKELSLLR NRKLGFVFQF HYLIPELTAL
110 120 130 140 150
ENVIVPMLKM GKPKKEAKER GEYLLSELGL GDKLSRKPYE LSGGEQQRVA
160 170 180 190 200
IARALANEPI LLFADEPTGN LDSANTKRVM DIFLKINEGG TSIVMVTHER
210 220
ELAELTHRTL EMKDGKVVGE ITRV
Length:224
Mass (Da):24,887
Last modified:August 1, 1998 - v1
Checksum:i0804B347486A963C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06596.1.
PIRiB70327.
RefSeqiNP_213206.1. NC_000918.1.
WP_010880144.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06596; AAC06596; aq_297.
GeneIDi1192880.
KEGGiaae:aq_297.
PATRICi20958210. VBIAquAeo85532_0244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06596.1.
PIRiB70327.
RefSeqiNP_213206.1. NC_000918.1.
WP_010880144.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PCJX-ray1.70A/B1-224[»]
2PCLX-ray1.70A1-224[»]
ProteinModelPortaliO66646.
SMRiO66646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_297.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06596; AAC06596; aq_297.
GeneIDi1192880.
KEGGiaae:aq_297.
PATRICi20958210. VBIAquAeo85532_0244.

Phylogenomic databases

eggNOGiENOG4107XPZ. Bacteria.
COG1136. LUCA.
InParanoidiO66646.
KOiK09810.
OMAiKESNIAF.
OrthoDBiPOG091H023H.

Miscellaneous databases

EvolutionaryTraceiO66646.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015854. ABC_transpr_LolD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51244. LOLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLOLD_AQUAE
AccessioniPrimary (citable) accession number: O66646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.