O66612 (OGG1_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

1. 8-oxoguanine DNA glycosylase
   EC=3.2.2.-
2. DNA-(apurinic or apyrimidinic site) lyase
   Short name=AP lyase
   EC=4.2.99.18

Gene names

Name:	ogg
Ordered Locus Names:	aq_251

Organism

Aquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Aquificae › Aquificae › Aquificales › Aquificaceae › Aquifex › Aquifex aeolicus

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241
Catalytic activity	The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241
Sequence similarities	Belongs to the type-2 OGG1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Molecular function	Glycosidase Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme Reference proteome
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA-(apurinic or apyrimidinic site) lyase activity Inferred from electronic annotation. Source: HAMAP hydrolase activity, hydrolyzing N-glycosyl compounds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241		PRO_0000159570
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O66612 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 90DE4DCED18FC20D	FASTA	226	26,306
	10 20 30 40 50 60 MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL FSELSFCILT 70 80 90 100 110 120 ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA GQRAERIVEA REKFPKVKSL 130 140 150 160 170 180 IEKEKNSKVI RELLADPKSP YKIKGFGYKE ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL 190 200 210 220 RQVKSITPKV YLEAEKALES LAKELGLSLG ELDLYIFYIK TKKVLK

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06576.1.
PIR	H70322.
RefSeq	NP_213172.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O66612.
ModBase	Search...
Protein-protein interaction databases
STRING	224324.aq_251.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC06576; AAC06576; aq_251.
GeneID	1192846.
KEGG	aae:aq_251.
PATRIC	20958128. VBIAquAeo85532_0204.
Phylogenomic databases
eggNOG	COG1059.
HOGENOM	HOG000224507.
KO	K03653.
OMA	IIDRHIL.
ProtClustDB	PRK01229.
Enzyme and pathway databases
BioCyc	AAEO224324:GJBH-187-MONOMER.
Family and domain databases
HAMAP	MF_00241. Ogg.
InterPro	IPR012092. DNA_glyclase/DNA_lyase_thermo. IPR011257. DNA_glycosylase. IPR003265. HhH-GPD_domain. [Graphical view]
PIRSF	PIRSF005954. Thrmst_ogg. 1 hit.
SMART	SM00478. ENDO3c. 1 hit. [Graphical view]
SUPFAM	SSF48150. DNA_glycsylse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OGG1_AQUAE

Accession

Primary (citable) accession number: O66612

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program