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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).By similarity

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei149By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciAAEO224324:G1G15-185-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:aq_251
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595701 – 226Probable N-glycosylase/DNA lyaseAdd BLAST226

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_251

Structurei

3D structure databases

ProteinModelPortaliO66612
SMRiO66612
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiENOG4105GRF Bacteria
COG1059 LUCA
HOGENOMiHOG000224507
InParanoidiO66612
KOiK03653
OMAiGYKEASH
OrthoDBiPOG091H3MT9

Family and domain databases

CDDicd00056 ENDO3c, 1 hit
Gene3Di1.10.1670.10, 2 hits
HAMAPiMF_00241 Ogg, 1 hit
InterProiView protein in InterPro
IPR012092 DNA_glyclase/DNA_lyase_thermo
IPR011257 DNA_glycosylase
IPR003265 HhH-GPD_domain
IPR023170 HTH_base_excis_C
PIRSFiPIRSF005954 Thrmst_ogg, 1 hit
SMARTiView protein in SMART
SM00478 ENDO3c, 1 hit
SUPFAMiSSF48150 SSF48150, 1 hit

Sequencei

Sequence statusi: Complete.

O66612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL
60 70 80 90 100
FSELSFCILT ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA
110 120 130 140 150
GQRAERIVEA REKFPKVKSL IEKEKNSKVI RELLADPKSP YKIKGFGYKE
160 170 180 190 200
ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL RQVKSITPKV YLEAEKALES
210 220
LAKELGLSLG ELDLYIFYIK TKKVLK
Length:226
Mass (Da):26,306
Last modified:August 1, 1998 - v1
Checksum:i90DE4DCED18FC20D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA Translation: AAC06576.1
PIRiH70322
RefSeqiNP_213172.1, NC_000918.1
WP_010880110.1, NC_000918.1

Genome annotation databases

EnsemblBacteriaiAAC06576; AAC06576; aq_251
GeneIDi1192846
KEGGiaae:aq_251

Similar proteinsi

Entry informationi

Entry nameiOGG1_AQUAE
AccessioniPrimary (citable) accession number: O66612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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