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O66612

- OGG1_AQUAE

UniProt

O66612 - OGG1_AQUAE

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Protein
Probable N-glycosylase/DNA lyase
Gene
ogg, aq_251
Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491 By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-187-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:aq_251
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Probable N-glycosylase/DNA lyaseUniRule annotation
PRO_0000159570Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_251.

Structurei

3D structure databases

ProteinModelPortaliO66612.

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiLDLYLWY.
OrthoDBiEOG68SW1J.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

O66612-1 [UniParc]FASTAAdd to Basket

« Hide

MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL    50
FSELSFCILT ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA 100
GQRAERIVEA REKFPKVKSL IEKEKNSKVI RELLADPKSP YKIKGFGYKE 150
ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL RQVKSITPKV YLEAEKALES 200
LAKELGLSLG ELDLYIFYIK TKKVLK 226
Length:226
Mass (Da):26,306
Last modified:August 1, 1998 - v1
Checksum:i90DE4DCED18FC20D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06576.1.
PIRiH70322.
RefSeqiNP_213172.1. NC_000918.1.
WP_010880110.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06576; AAC06576; aq_251.
GeneIDi1192846.
KEGGiaae:aq_251.
PATRICi20958128. VBIAquAeo85532_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06576.1 .
PIRi H70322.
RefSeqi NP_213172.1. NC_000918.1.
WP_010880110.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06576 ; AAC06576 ; aq_251 .
GeneIDi 1192846.
KEGGi aae:aq_251.
PATRICi 20958128. VBIAquAeo85532_0204.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OMAi LDLYLWY.
OrthoDBi EOG68SW1J.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-187-MONOMER.

Family and domain databases

HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiOGG1_AQUAE
AccessioniPrimary (citable) accession number: O66612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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