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O66612 (OGG1_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:aq_251
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159570

Sites

Active site1491 By similarity

Sequences

Sequence LengthMass (Da)Tools
O66612 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 90DE4DCED18FC20D

FASTA22626,306
        10         20         30         40         50         60 
MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL FSELSFCILT 

        70         80         90        100        110        120 
ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA GQRAERIVEA REKFPKVKSL 

       130        140        150        160        170        180 
IEKEKNSKVI RELLADPKSP YKIKGFGYKE ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL 

       190        200        210        220 
RQVKSITPKV YLEAEKALES LAKELGLSLG ELDLYIFYIK TKKVLK 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC06576.1.
PIRH70322.
RefSeqNP_213172.1. NC_000918.1.

3D structure databases

ProteinModelPortalO66612.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_251.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC06576; AAC06576; aq_251.
GeneID1192846.
KEGGaae:aq_251.
PATRIC20958128. VBIAquAeo85532_0204.

Phylogenomic databases

eggNOGCOG1059.
HOGENOMHOG000224507.
KOK03653.
OMALDLYLWY.
OrthoDBEOG68SW1J.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-187-MONOMER.

Family and domain databases

HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
ProtoNetSearch...

Entry information

Entry nameOGG1_AQUAE
AccessionPrimary (citable) accession number: O66612
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families