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O66612

- OGG1_AQUAE

UniProt

O66612 - OGG1_AQUAE

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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).By similarity

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491By similarity

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-187-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyase
Including the following 2 domains:
8-oxoguanine DNA glycosylase (EC:3.2.2.-)
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Short name:
AP lyase
Gene namesi
Name:ogg
Ordered Locus Names:aq_251
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
ProteomesiUP000000798: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Probable N-glycosylase/DNA lyasePRO_0000159570Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_251.

Structurei

3D structure databases

ProteinModelPortaliO66612.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.Curated

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
InParanoidiO66612.
KOiK03653.
OMAiLDLYLWY.
OrthoDBiEOG68SW1J.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

O66612 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL
60 70 80 90 100
FSELSFCILT ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA
110 120 130 140 150
GQRAERIVEA REKFPKVKSL IEKEKNSKVI RELLADPKSP YKIKGFGYKE
160 170 180 190 200
ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL RQVKSITPKV YLEAEKALES
210 220
LAKELGLSLG ELDLYIFYIK TKKVLK
Length:226
Mass (Da):26,306
Last modified:August 1, 1998 - v1
Checksum:i90DE4DCED18FC20D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06576.1.
PIRiH70322.
RefSeqiNP_213172.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06576; AAC06576; aq_251.
GeneIDi1192846.
KEGGiaae:aq_251.
PATRICi20958128. VBIAquAeo85532_0204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000657 Genomic DNA. Translation: AAC06576.1 .
PIRi H70322.
RefSeqi NP_213172.1. NC_000918.1.

3D structure databases

ProteinModelPortali O66612.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224324.aq_251.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC06576 ; AAC06576 ; aq_251 .
GeneIDi 1192846.
KEGGi aae:aq_251.
PATRICi 20958128. VBIAquAeo85532_0204.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
InParanoidi O66612.
KOi K03653.
OMAi LDLYLWY.
OrthoDBi EOG68SW1J.

Enzyme and pathway databases

BioCyci AAEO224324:GJBH-187-MONOMER.

Family and domain databases

HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5.

Entry informationi

Entry nameiOGG1_AQUAE
AccessioniPrimary (citable) accession number: O66612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3