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O66612

- OGG1_AQUAE

UniProt

O66612 - OGG1_AQUAE

Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity.By similarity

    Catalytic activityi

    The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491By similarity

    GO - Molecular functioni

    1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase, Lyase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciAAEO224324:GJBH-187-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-glycosylase/DNA lyase
    Including the following 2 domains:
    8-oxoguanine DNA glycosylase (EC:3.2.2.-)
    DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
    Short name:
    AP lyase
    Gene namesi
    Name:ogg
    Ordered Locus Names:aq_251
    OrganismiAquifex aeolicus (strain VF5)
    Taxonomic identifieri224324 [NCBI]
    Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
    ProteomesiUP000000798: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226Probable N-glycosylase/DNA lyasePRO_0000159570Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224324.aq_251.

    Structurei

    3D structure databases

    ProteinModelPortaliO66612.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type-2 OGG1 family.Curated

    Phylogenomic databases

    eggNOGiCOG1059.
    HOGENOMiHOG000224507.
    KOiK03653.
    OMAiLDLYLWY.
    OrthoDBiEOG68SW1J.

    Family and domain databases

    HAMAPiMF_00241. Ogg.
    InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view]
    PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
    SMARTiSM00478. ENDO3c. 1 hit.
    [Graphical view]
    SUPFAMiSSF48150. SSF48150. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O66612-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAIQEVKRI IPEVQKYVNQ RMEEFERLGR EGWTHFDFRP FLDIDYDAGL    50
    FSELSFCILT ANSSATLGIK IQAHLGEEGF LNKTKEELEE VFRKFGHRYA 100
    GQRAERIVEA REKFPKVKSL IEKEKNSKVI RELLADPKSP YKIKGFGYKE 150
    ASHFLRNIGF KDLAIIDRHI SRFLMEKGLL RQVKSITPKV YLEAEKALES 200
    LAKELGLSLG ELDLYIFYIK TKKVLK 226
    Length:226
    Mass (Da):26,306
    Last modified:August 1, 1998 - v1
    Checksum:i90DE4DCED18FC20D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06576.1.
    PIRiH70322.
    RefSeqiNP_213172.1. NC_000918.1.
    WP_010880110.1. NC_000918.1.

    Genome annotation databases

    EnsemblBacteriaiAAC06576; AAC06576; aq_251.
    GeneIDi1192846.
    KEGGiaae:aq_251.
    PATRICi20958128. VBIAquAeo85532_0204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000657 Genomic DNA. Translation: AAC06576.1 .
    PIRi H70322.
    RefSeqi NP_213172.1. NC_000918.1.
    WP_010880110.1. NC_000918.1.

    3D structure databases

    ProteinModelPortali O66612.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224324.aq_251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC06576 ; AAC06576 ; aq_251 .
    GeneIDi 1192846.
    KEGGi aae:aq_251.
    PATRICi 20958128. VBIAquAeo85532_0204.

    Phylogenomic databases

    eggNOGi COG1059.
    HOGENOMi HOG000224507.
    KOi K03653.
    OMAi LDLYLWY.
    OrthoDBi EOG68SW1J.

    Enzyme and pathway databases

    BioCyci AAEO224324:GJBH-187-MONOMER.

    Family and domain databases

    HAMAPi MF_00241. Ogg.
    InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
    IPR011257. DNA_glycosylase.
    IPR003265. HhH-GPD_domain.
    [Graphical view ]
    PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
    SMARTi SM00478. ENDO3c. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48150. SSF48150. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: VF5.

    Entry informationi

    Entry nameiOGG1_AQUAE
    AccessioniPrimary (citable) accession number: O66612
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3