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Protein
Submitted name:

Transcriptional regulator (NifA family)

Gene

nifA

Organism
Aquifex aeolicus (strain VF5)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-166-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator (NifA family)Imported
Gene namesi
Name:nifAImported
Ordered Locus Names:aq_218Imported
OrganismiAquifex aeolicus (strain VF5)Imported
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi224324.aq_218.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4G3KX-ray3.05A/B1-175[»]
4G3WX-ray2.70A1-171[»]
ProteinModelPortaliO66591.
SMRiO66591. Positions 191-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 423229Sigma-54 factor interactionInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili162 – 18928Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 sigma-54 factor interaction domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4108JUA. Bacteria.
COG3604. LUCA.
HOGENOMiHOG000058487.
InParanoidiO66591.
KOiK02584.
OMAiGLHRSSI.
OrthoDBiEOG6WHNMG.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02954. HTH_8. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O66591-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKVEIETL YEVSKILSSS LNLETTVPYI FRLLKKLMGF ERLTLTIYDP
60 70 80 90 100
STDQIVVRAT SSGKFPKEGF KKGEGITGKV WKHGVPIVIP DISQEPEFLN
110 120 130 140 150
KVWKRKKSKK KIAFIAVPIK SGGKVIGVLS ADKEINEKDS LDEYTRFLSM
160 170 180 190 200
IATLIANSFS LERKVQAERK SLEEEKRALE TELKRVYEKL HVEGIVGRSK
210 220 230 240 250
EILNVLEIVH RVAPTNATVL LRGESGVGKE VFARAIHFLS PRADKPFVAI
260 270 280 290 300
NCGAIPGELL EAELFGYEKG AFTGAYSTKK GKFELANGGT LFLDEIGELP
310 320 330 340 350
LHLQVKLLRA IQEKEIERIG GTRPIKVDVR IIAATNRDLE SMVREGKFRE
360 370 380 390 400
DLYYRLNVVP IFIPPLRERK EDIPVLVHYF LEKFSKEYNK EVSITQEVMD
410 420 430 440 450
AFMKYEWKGN VRELQNVLER MVILDTDGVL SEEDLPPEIR DVKKESRIYN
460 470 480 490 500
QTLNGETIWD LEKQLIEKAL EESGFVIKEA AKKLGMTPRQ VSYRIQKYGI

KLPKKR
Length:506
Mass (Da):57,756
Last modified:August 1, 1998 - v1
Checksum:i54CF8248DD931EEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06546.1.
PIRiC70320.
RefSeqiNP_213151.1. NC_000918.1.
WP_010880089.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06546; AAC06546; aq_218.
GeneIDi1192825.
KEGGiaae:aq_218.
PATRICi20958084. VBIAquAeo85532_0182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06546.1.
PIRiC70320.
RefSeqiNP_213151.1. NC_000918.1.
WP_010880089.1. NC_000918.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4G3KX-ray3.05A/B1-175[»]
4G3WX-ray2.70A1-171[»]
ProteinModelPortaliO66591.
SMRiO66591. Positions 191-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_218.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06546; AAC06546; aq_218.
GeneIDi1192825.
KEGGiaae:aq_218.
PATRICi20958084. VBIAquAeo85532_0182.

Phylogenomic databases

eggNOGiENOG4108JUA. Bacteria.
COG3604. LUCA.
HOGENOMiHOG000058487.
InParanoidiO66591.
KOiK02584.
OMAiGLHRSSI.
OrthoDBiEOG6WHNMG.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-166-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
3.30.450.40. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003018. GAF.
IPR029016. GAF_dom-like.
IPR009057. Homeodomain-like.
IPR002197. HTH_Fis.
IPR027417. P-loop_NTPase.
IPR002078. Sigma_54_int.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR025943. Sigma_54_int_dom_ATP-bd_2.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02954. HTH_8. 1 hit.
PF00158. Sigma54_activat. 1 hit.
[Graphical view]
PRINTSiPR01590. HTHFIS.
SMARTiSM00382. AAA. 1 hit.
SM00065. GAF. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
PROSITEiPS00675. SIGMA54_INTERACT_1. 1 hit.
PS00676. SIGMA54_INTERACT_2. 1 hit.
PS50045. SIGMA54_INTERACT_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: VF5Imported.
  2. "Structural mechanism of GAF-regulated sigma(54) activators from Aquifex aeolicus."
    Batchelor J.D., Lee P.S., Wang A.C., Doucleff M., Wemmer D.E.
    J. Mol. Biol. 425:156-170(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 1-171.

Entry informationi

Entry nameiO66591_AQUAE
AccessioniPrimary (citable) accession number: O66591
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.