ID   NTPA_AQUAE              Reviewed;         202 AA.
AC   O66580;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=Nucleoside-triphosphatase;
DE            EC=3.6.1.15;
DE   AltName: Full=Nucleoside triphosphate phosphohydrolase;
DE            Short=NTPase;
GN   OrderedLocusNames=aq_202;
OS   Aquifex aeolicus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=63363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Hydrolyzes non-standard nucleotides such as XTP and
CC       dITP/ITP. Might exclude non-standard purines from DNA precursor
CC       pool, preventing thus incorporation into DNA and avoiding
CC       chromosomal lesions (By similarity).
CC   -!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
CC   -!- COFACTOR: Divalent cations (By similarity).
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the HAM1 NTPase family.
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DR   EMBL; AE000657; AAC06551.1; -; Genomic_DNA.
DR   PIR; H70318; H70318.
DR   RefSeq; NP_213140.1; -.
DR   HSSP; Q57679; 1B78.
DR   GeneID; 1192722; -.
DR   GenomeReviews; AE000657_GR; aq_202.
DR   KEGG; aae:aq_202; -.
DR   NMPDR; fig|224324.1.peg.155; -.
DR   HOGENOM; O66580; -.
DR   OMA; O66580; VYTADWA.
DR   BioCyc; AAEO224324:AQ_202-MON; -.
DR   BRENDA; 3.6.1.15; 189781.
DR   GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:HAMAP.
DR   HAMAP; MF_01405; -; 1.
DR   InterPro; IPR002637; Ham1p-like.
DR   PANTHER; PTHR11067; Ham1p_like; 1.
DR   Pfam; PF01725; Ham1p_like; 1.
DR   TIGRFAMs; TIGR00042; Ham1p_like; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    202       Nucleoside-triphosphatase.
FT                                /FTId=PRO_0000178117.
SQ   SEQUENCE   202 AA;  23115 MW;  6709937433F47385 CRC64;
     MKLLVATTNE GKYREIKEIL SEYGIEVLKP EEKLEVEETG CTFLENAYLK ARAYYERYKI
     PALADDSGLI VEAISPYPGV YSSRFYDIDF GGREEVRTNK DEANIRKLLR LLENTENRKA
     KFVAFIVVYG GSWGIFAEGE VRGEITKEPR GDRGFGYDPV FVPEGYNKTM AELSPEEKNK
     ISHRGRALRK LVHVLKNCEK AF
//