O66566 (ATP6_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit a

Alternative name(s):
ATP synthase F0 sector subunit a
F-ATPase subunit 6

Gene names

Name:	atpB
Ordered Locus Names:	aq_179

Organism

Aquifex aeolicus (strain VF5)

Taxonomic identifier

224324 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane By similarity. HAMAP MF_01393
Subunit structure	F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01393.
Sequence similarities	Belongs to the ATPase A chain family.

Ontologies

Keywords
Biological process	ATP synthesis Hydrogen ion transport Ion transport Transport
Cellular component	CF(0) Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP synthesis coupled proton transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell proton-transporting ATP synthase complex, coupling factor F(o) Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	hydrogen ion transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	ATP synthase subunit a HAMAP MF_01393		PRO_0000082041
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	119 – 139	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	174 – 194	21	Helical; Potential
	Transmembrane	196 – 216	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O66566 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 0BEB8E0674D0FF5F	FASTA	216	24,025
	10 20 30 40 50 60 MEYSHVVYAL LAVALAIIFV LKGGKPSLKP TKYQALLEGY LRFVRNMLLE NVGERGLKYV 70 80 90 100 110 120 PLIAAIGLFV FFGNILGMVP GFEAPTANIN TNLALALLVF FYYHFEGFRE NGLAYLKHFM 130 140 150 160 170 180 GPIPLMAPFF FVVEVISHIA RPITLSLRLF ANMKAGALLL LTLVSLVIKN PFTLVVSPVV 190 200 210 LIFVIAIKFL AIFIQTYIFM ILSVVYIAGA VAHEEH

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000657 Genomic DNA. Translation: AAC06523.1.
PIR	B70317.
RefSeq	NP_213126.1. NC_000918.1.
3D structure databases
ProteinModelPortal	O66566.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1192708.
GenomeReviews	Gene locus aq_179 in contig AE000657_GR.
KEGG	aae:aq_179.
NMPDR	fig|224324.1.peg.141.
PATRIC	20958032. VBIAquAeo85532_0156.
Phylogenomic databases
HOGENOM	HBG734175.
OMA	SKMQLVP.
PhylomeDB	O66566.
ProtClustDB	CLSK2299324.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_179-MONOMER.
Family and domain databases
HAMAP	MF_01393. ATP_synth_a_bact. [Tree]
InterPro	IPR000568. ATPase_F0-cplx_asu. IPR023011. ATPase_F0-cplx_asu_AS. [Graphical view]
Gene3D	G3DSA:1.20.120.220. ATPase_F0_A. 1 hit.
KO	K02108.
PANTHER	PTHR11410. ATPase_F0_A. 1 hit.
Pfam	PF00119. ATP-synt_A. 1 hit. [Graphical view]
PRINTS	PR00123. ATPASEA.
SUPFAM	SSF81336. ATPase_F0_A. 1 hit.
TIGRFAMs	TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITE	PS00449. ATPASE_A. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATP6_AQUAE

Accession

Primary (citable) accession number: O66566

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program