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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-136-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:aq_175
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalUniRule annotationAdd
BLAST
Transmembranei286 – 30621HelicalUniRule annotationAdd
BLAST
Transmembranei312 – 33221HelicalUniRule annotationAdd
BLAST
Transmembranei382 – 40221HelicalUniRule annotationAdd
BLAST
Transmembranei409 – 42921HelicalUniRule annotationAdd
BLAST
Transmembranei452 – 47221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Membrane protein insertase YidCPRO_0000124686Add
BLAST

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_175.

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000101820.
InParanoidiO66561.
KOiK03217.
OMAiWAGEENK.
OrthoDBiPOG091H00BE.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
PRINTSiPR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

O66561-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDNDNQFWK RFLIFTILMF LFITAYELFY IYYVKPSQPQ KTEKKEVVKK
60 70 80 90 100
EEFKNVNLPQ LMLGTFREKQ EYKNTKTVKL GIYSLELSEK GGKILRFIDQ
110 120 130 140 150
KYGFDLISKA ERELKIFPLE IFTGNPDLDQ KLNFGEYEIK EGKNSVELIH
160 170 180 190 200
KELKVKKILS YKNGAIHLSV EGLKPPFWVF VGSPPDDEAF YTHVGPVLKI
210 220 230 240 250
NGEVVRLDVD DLKGINEFEG NIEFGGEESR YFFKGAKDYQ KHIVYKVKLG
260 270 280 290 300
DKFVSLSTFL YDGEKTIYLG AKDYARLREL GLVDTLDWGT LKIIVKPLFL
310 320 330 340 350
FLYWIYEHTG SWVLSILVLT FIVRIFLFPL GYKSVVSMQK LQELAPKMEK
360 370 380 390 400
IKQKYKDDPV KMQEEMMKLY AETGFNPMAG CLPILLQIPI FFALYKVLII
410 420 430 440 450
TVDLKVSSFL WIPSLADKDP YYILPVIMGL TMILQQKMTP SPDPKQALVG
460 470 480 490 500
YITSVAFTLL FINFPAGLVL YWTLNNVFNI IQNYLIKEVL LKDKSKGGSK

KK
Length:502
Mass (Da):58,225
Last modified:August 1, 1998 - v1
Checksum:i6C24B8405F2570AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06534.1.
PIRiF70316.
RefSeqiNP_213121.1. NC_000918.1.
WP_010880059.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC06534; AAC06534; aq_175.
GeneIDi1192704.
KEGGiaae:aq_175.
PATRICi20958022. VBIAquAeo85532_0151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC06534.1.
PIRiF70316.
RefSeqiNP_213121.1. NC_000918.1.
WP_010880059.1. NC_000918.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC06534; AAC06534; aq_175.
GeneIDi1192704.
KEGGiaae:aq_175.
PATRICi20958022. VBIAquAeo85532_0151.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000101820.
InParanoidiO66561.
KOiK03217.
OMAiWAGEENK.
OrthoDBiPOG091H00BE.

Enzyme and pathway databases

BioCyciAAEO224324:GJBH-136-MONOMER.

Family and domain databases

HAMAPiMF_01810. YidC_type1. 1 hit.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
PRINTSiPR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOXAA_AQUAE
AccessioniPrimary (citable) accession number: O66561
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.