ID   P5CR_AQUAE              Reviewed;         265 AA.
AC   O66553;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=proC; OrderedLocusNames=aq_166;
OS   Aquifex aeolicus.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=63363;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   MEDLINE=98196666; PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex
RT   aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE000657; AAC06504.1; -; Genomic_DNA.
DR   PIR; F70315; F70315.
DR   RefSeq; NP_213113.1; -.
DR   GeneID; 1192696; -.
DR   GenomeReviews; AE000657_GR; aq_166.
DR   KEGG; aae:aq_166; -.
DR   NMPDR; fig|224324.1.peg.128; -.
DR   HOGENOM; O66553; -.
DR   OMA; O66553; LKQGYPA.
DR   BioCyc; AAEO224324:AQ_166-MON; -.
DR   BRENDA; 1.5.1.2; 189781.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP;
KW   Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    265       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187284.
SQ   SEQUENCE   265 AA;  28814 MW;  32DD6B49EDDCF403 CRC64;
     MHAIILTMRV GIVGFGNMGQ AFALCFSKKL GKENIIVTDK VQEKRNLATE MGIAFASDVK
     FLADNSDVVL VAVKPKDSQE VLQKLKDYKG IILSIMAGVS IEKMEKILGK DKKIVRVMPN
     VNVAVGSGVM AITDNGNLSE EERSKVEELL LSCGTLYRIE ERLFDAFTAL AGSGPAFVFS
     FIDALALAGV HQGFSYEQAL RIALDTVMGS AKLLKEFQVN PNELIAKVTS PGGTTIEGIK
     YLEEKGFKGT VMECINRTSQ KAKKL
//