Reviewed, UniProtKB/Swiss-Prot O66553 (P5CR_AQUAE)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	aq_166

Organism

Aquifex aeolicus [Complete proteome] [HAMAP]

Taxonomic identifier

63363 [NCBI]

Taxonomic lineage

Bacteria › Aquificae › Aquificales › Aquificaceae › Aquifex

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Pyrroline-5-carboxylate reductase		PRO_0000187284

Sequences

	Sequence		Length	Mass (Da)
	O66553-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 32DD6B49EDDCF403	FASTA	265	28,814
	10 20 30 40 50 60 MHAIILTMRV GIVGFGNMGQ AFALCFSKKL GKENIIVTDK VQEKRNLATE MGIAFASDVK 70 80 90 100 110 120 FLADNSDVVL VAVKPKDSQE VLQKLKDYKG IILSIMAGVS IEKMEKILGK DKKIVRVMPN 130 140 150 160 170 180 VNVAVGSGVM AITDNGNLSE EERSKVEELL LSCGTLYRIE ERLFDAFTAL AGSGPAFVFS 190 200 210 220 230 240 FIDALALAGV HQGFSYEQAL RIALDTVMGS AKLLKEFQVN PNELIAKVTS PGGTTIEGIK 250 260 YLEEKGFKGT VMECINRTSQ KAKKL

References

[1]

"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus." Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V. Nature 392:353-358(1998) [PubMed: 9537320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: VF5.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE000657 Genomic DNA. Translation: AAC06504.1.
PIR	F70315.
RefSeq	NP_213113.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1192696.
GenomeReviews	Gene locus aq_166 in contig AE000657_GR.
KEGG	aae:aq_166.
NMPDR	fig|224324.1.peg.128.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	O66553.
Enzyme and pathway databases
BioCyc	AAEO224324:AQ_166-MON.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	O66553.

Entry information

Entry name

P5CR_AQUAE

Accession

Primary (citable) accession number: O66553

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)